Notes

Efficacy regarding dupilumab within Eosinophilic Dermatosis of Haematologic Metastasizing cancer (EDHM) should be validated.
PM2.5 pollution episodes rapidly and significantly deteriorate the air quality and are a critical concern worldwide. This study developed a fusion method based on the moving window dataset technique and constrained Positive Matrix Factorization (PMF) to differentiate and characterize potential factors in a PM2.5 episode case assuming having one new contributor. The hourly PM2.5 compositions of elements, ions and carbonaceous components, were collected from September to December 2020 in Taipei, Taiwan. Constraint targets based on the bootstrap analysis result of a PMF model using a long-term input dataset were imposed on the modeling of each moving window to ensure similar features of the retrieved factors. The constituents of an additionally differentiated factor to the episode, which was identified as regional transport, were stable among each moving window that covered the occurrence of the episode as revealed by the profile matching index. The results showed that the largest contributor to the PM2.5 mass during the episode period of 12/12/2020 was regional transport (61%), whereas that of 12/13 was the regular pollution of industry/ammonium sulfate related (43%). According to our review of the literature, this study is the first to apply both the moving window technique and constrained PMF to characterize the episode. The findings provide valuable information that can be used to explore the causes of PM2.5 episodes and implement air pollution control strategies.Adaptation to breathing is a critical step in lung function and it is crucial for organismal survival. Alveoli are the lung gas exchange units and their development, from late embryonic to early postnatal stages, requires feedbacks between multiple cell types. However, how the crosstalk between the alveolar cell types is modulated to anticipate lung adaptation to breathing is still unclear. Here, we uncovered a synchronous alternative splicing switch in multiple genes in the developing mouse lungs at the transition to birth, and we identified hnRNP A1, Cpeb4, and Elavl2/HuB as putative splicing regulators of this transition. see more Notably, we found that <i>Vegfa</i> switches from the <i>Vegfa</i> 164 isoform to the longer <i>Vegfa</i> 188 isoform exclusively in lung alveolar epithelial AT1 cells. Functional analysis revealed that VEGFA 188 (and not VEGFA 164) drives the specification of Car4-positive aerocytes, a subtype of alveolar endothelial cells specialized in gas exchanges. Our results reveal that the cell type-specific regulation of <i>Vegfa</i> alternative splicing just before birth modulates the epithelial-endothelial crosstalk in the developing alveoli to promote lung adaptation to breathing.
In New South Wales (NSW), Australia, the number of 'online liquor licences' - packaged liquor licences with conditions restricting the sale of alcohol to online, phone or fax orders - increased from 101 in 2010 to 500 by May 2018. International and national evidence is emerging that this growth in online liquor licences has been accompanied by increased risk of supply to young and intoxicated people. This study aimed to determine the extent to which online liquor retailers in NSW have adopted safeguards to prevent people younger than 18 years purchasing alcohol online; and the supply of alcohol to intoxicated people. It also aimed to assess the regulatory framework in NSW for these licences.

We undertook an audit between May and November 2018 of regulatory controls for 213 online liquor retailers in NSW with publicly available websites at the time of auditing. A comparative analysis of the NSW Liquor Act 2007 and the NSW Liquor Regulation 2018 was conducted.

Three gaps in the existing legal safeguards f written submissions from the research group on behalf of Northern Sydney Local Health District Health Promotion. Several key reforms were subsequently incorporated into the NSW Liquor Amendment (24-hour Economy) Bill 2020. Findings have informed an advocacy approach which has led to improved regulatory reform within NSW.
Alcohol contributes to significant health, social and economic burdens worldwide, but evidence-based policy options can reduce the harm associated with alcohol use. The aim of this paper is to understand factors influencing public support for various alcohol policies in New South Wales (NSW), Australia, and to determine any change over time.

An online survey of adults in NSW, in 2013 (n = 2482), 2016 (n = 1585) and 2019 (n = 1601), assessed support for alcohol policies. Multivariable logistic regression models examined the change in support over time, adjusting for demographics, alcohol consumption, smoking status and knowledge of alcohol as a risk factor for cancer.

Most participants (68-72%) supported policies preventing underage internet users from exposure to alcohol advertising, and banning alcohol sponsorship of underage music and sporting events. Fiscal policies and restrictions on the number of alcohol outlets were the least supported policies (<40% support). Compared with 2013, participants d to counter industry influence on decision makers and negative public discourse.Cataract surgery is a safe, effective and common elective procedure in Australia but access is inequitable. True waiting times for cataract care are undisclosed or inconsistently reported by governments. Estimates of true waiting times range from 4 to 30 months and have been extended during the coronavirus disease 2019 (COVID-19) pandemic. Comparative analysis revealed that reducing waiting periods from 12 to 3 months would result in estimated public health system cost savings of $6.6 million by preventing 50 679 falls. Investment in public cataract services to address current unmet needs would prevent avoidable vision impairment and associated negative consequences.
This paper aims to identify challenges in current health service approaches to providing optimal care for people who seek treatment for obesity. Type of program or service Health service management of obesity in Australia Methods Drawing on lived experience, clinical and academic perspectives, and available evidence, we reflect on the current state of the healthcare system to support people seeking treatment for obesity. We suggest actions to enable effective, acceptable and equitable care for this group of people.

Identified challenges include the complexity of care required to adequately manage obesity, existing service capability and capacity, and high out-of-pocket patient costs.

To address these challenges, a comprehensive response is required at all levels of the healthcare system. As a starting point, we propose eight areas of action partner with people living with obesity; eliminate weight stigma; increase healthcare professional education, guidelines and resources; establish clear referral pathways and working partnerships; scale services to meet demand; ensure flexible and accessible service delivery; implement changes to the Medicare Benefits Schedule to increase service provision and pursue opportunities for subsidised medicines.
To address these challenges, a comprehensive response is required at all levels of the healthcare system. As a starting point, we propose eight areas of action partner with people living with obesity; eliminate weight stigma; increase healthcare professional education, guidelines and resources; establish clear referral pathways and working partnerships; scale services to meet demand; ensure flexible and accessible service delivery; implement changes to the Medicare Benefits Schedule to increase service provision and pursue opportunities for subsidised medicines.
To explore opportunities to change increasing weight gain trajectories for women during their reproductive lives, focusing on optimising health before pregnancy. Type of program Identifying optimal policies, health promotion and health services to support preconception health for women (with a focus on achieving a healthy weight).

Narrative description of changing policies and approaches for improving preconception health.

Preconception preventive health priorities have been clearly determined globally and nationally. However, further rigorous research for effective interventions to facilitate healthy weight and other aspects of preconception health, alongside effective policies and strategies for implementing these interventions, remains potentially important. Barriers for women, their partners, families, communities and health professionals must be overcome and enablers fostered. The inclusion of preconception lifestyle health to tackle maternal and childhood obesity as a key priority of the World Hea shown to help internationally and can be applied in Australia.
Nutrition across the first 2000 days of life, from conception to age five, is considered critical in shaping lifelong nutrition and health outcomes, with dietary patterns tracking from infancy into later childhood and adulthood. Identifying potential policy, programmatic, and research opportunities is essential to inform action in this area.

This research was undertaken to provide an overview of the evidence support, policy mechanisms and stakeholder perspectives on opportunities for improving nutrition across the first 2000 days of life to guide future investments and to inform policy dialogues with relevant government, non-government and external agencies within the state of Victoria, Australia.

Underpinned by UNICEF's Innocenti Framework, this research comprised a) a rapid review of existing systematic reviews (n = 60) supplemented with key grey literature reports; b) mapping of potential policy and programmatic levers and partnerships against 14 identified areas; and c) qualitative semi-structured iortunities in close collaboration with stakeholders.Population groups, including Aboriginal and Torres Strait Islander peoples, people with disability, and people from culturally and linguistically diverse communities (CALD) experience health inequity and resulting disparities in disease rates. These include higher rates of obesity and associated chronic diseases. This paper brings together three perspectives by researchers in the fields of Indigenous health, disability and CALD health to examine how overweight and obesity impact these populations in Australia and to put forward ways of addressing the problem. The authors urge investment in research co-designed with people from each of these communities and with lived experience of obesity to build valuable knowledge about what preventive actions and interventions will work to reduce obesity rates. They call for evidence-based, tailored obesity prevention programs to address these historical disparities and improve health outcomes among some of Australia's disadvantaged populations.People living with obesity experience weight stigma in most social settings. This has a negative impact on their health and quality of life. A primary contributor to weight stigma is the misconception that obesity is caused by factors solely within an individual's control. However, this disregards the complex and multifaceted nature of obesity. Weight stigma is perpetuated by the media, healthcare practitioners and researchers, and even in public health campaigns and policies designed to help people living with obesity. This perspective article is a public health call to action to address weight stigma in Australia. We provide key recommendations for public health researchers, practitioners, and policy makers.
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