Notes

Target Steps regarding Retinal Graphic Destruction On account of Refractive Improvements.
Together, these results demonstrate a sex-specific role of adolescent endocannabinoid signalling in the normative development of social behaviours and provide further support for adolescence as a vulnerable period for the effects of altered endocannabinoid signalling. This article is protected by copyright. All rights reserved.INTRODUCTION Statins were proposed to be neuroprotective; however, the effects are unknown in progressive supranuclear palsy (PSP), a pure tauopathy. METHODS Data of 284 PSP cases and 284 age-matched, sex-matched, and race-matched controls were obtained from the environmental and genetic PSP (ENGENE-PSP) study. Cases were evaluated with the PSP Rating Scale, Unified Parkinson's Disease Rating Scale, Mattis Dementia Rating Scale, and Neuropsychiatric Inventory. Statin associations with PSP risk, onset age, and disease features were analyzed. RESULTS Univariate models showed lower PSP risk for type 1 statin users (simvastatin, lovastatin, pravastatin). After adjusting for confounding variables, statin use and lower PSP risk association remained only at a trend level. For PSP cases, type 1 statins were associated with 1-year older onset age; type 2 statins (atorvastatin, rosuvastatin) were associated with the lower PSP Rating Scale and Unified Parkinson's Disease Rating Scale. CONCLUSION Statins may have inverse associations with PSP risk and motor impairment. Randomized prospective studies are required to confirm this effect. © 2020 International Parkinson and Movement Disorder Society. © 2020 International Parkinson and Movement Disorder Society.A 75-year-old postmenopausal lady presented with the chief complaints of bleeding per vagina for the last 2 months. On examination, the lady had pallor. Per vaginal examination revealed an ulceroproliferative growth at the posterior lip of the cervix measuring 3 cm x 3cm. The growth was brownish-black. There was no inguinal lymphadenopathy. There was no mass elsewhere in the body. This article is protected by copyright. All rights reserved.AIMS AND OBJECTIVE To investigate the effects on the quality of care of the Patient Report Informing Self-Management Support (PRISMS) form compared with usual care among patients with Chronic Obstructive Pulmonary Disease (COPD) consulting a COPD nurse in primary health care. BACKGROUND Patients with COPD experience symptoms affecting their everyday lives and there is a need for interventions in self-management support. The delivery of chronic care in an organized, structured, and planned manner can lead to more productive relationships between professionals and patients. DESIGN A multicentre randomised controlled trial with a post-test design, according to the CONSORT checklist, in one intervention group (n=94) and one control group (n=108). METHODS In addition to usual care, the intervention group (n=94) completed the PRISMS form to indicate areas where they wanted self-management support before the consultation with the COPD nurse. This form comprises 17 items that patients with COPD commonly experience as tool in improving person-centred care when delivering self-management support. This article is protected by copyright. All rights reserved.A simple and efficient method for the regioselective iodophosphoryloxylation of alkenes with P(O)-OH bonds has been established by using NIS (N-iodosuccinimide) as the iodination reagent under transition-metal-free conditions. The present protocol is compatible with different functional groups, and suitable for various alkenes and P(O)-OH compounds. A variety of functionalized β-iodo-1-ethyl phosphinic/phosphoric acid esters are obtained in good to excellent yields, which could be further transformed to diversified building blocks for the synthesis of bioactive compounds, pharmaceuticals and functional materials . © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.AIM This study aimed to develop a grounded theory of the patients' experiences with patient-controlled admission BACKGROUND Research indicates a potential for involving patients in mental health care, but there is a need to develop and investigate new approaches in health services. Patient-controlled admission is an option for patients with severe mental disorders to refer themselves for a brief hospital admission when needed and thus avoid the usual admission procedure DESIGN Classic grounded theory with generation of a theory based on the constant comparative method for data collection and analysis. METHODS Field observations and interviews with 26 mental health patients. The COREQ checklist was followed. RESULTS We found that patient-controlled admission induced safety by providing faster access to help and thus preventing further deterioration of symptoms. Being self-determined, achieving calmness, and receiving care with support and guidance from professionals during admission contributed to the sense ofThis article is protected by copyright. All rights reserved.AIMS AND OBJECTIVES To synthesize and review literature related to instruments that measure psychosocial aspects of fundamental care in acute hospital care settings. BACKGROUND Psychosocial aspects of care often receive less priority in terms of care provision in acute care environments. At the same time if these elements are overlooked there may be consequences. Despite the availability of many instruments designed to measure specific aspects of care these concepts are often not studied within the broader context of fundamentals of care, but rather coexist as isolated explorations of specific sub elements. DESIGN A scoping review was conducted, based on Arksey & O'Malley's (2005) methodological framework and following the PRISMA checklist. METHODS Using the five recommended steps -identifying the research question; identifying relevant studies; study selection; charting the data; summarizing and reporting the results - three databases were searched MEDLINE/Pubmed, CINHAL, and EMBASE in February 2019. RESULTSht. All rights reserved.We use 60-MHz benchtop nuclear magnetic resonance (NMR) to acquire 1 H spectra from argan oils of assured origin. We show that the low-field NMR spectrum of neat oil contains sufficient information to make estimates of compositional parameters and to inform on the presence of minor compounds. A screening method for quality and authenticity is presented based on nearest-neighbour outlier detection. A variety of oil types are used to challenge the method. In a survey of retail-purchased oils, several instances of fraud were found. © 2020 The Authors. Magnetic Resonance in Chemistry published by John Wiley & Sons Ltd.We have quantum chemically studied the reactivity, site-, and regioselectivity of the 1,3-dipolar cycloaddition reaction between methyl azide and various allenes, including the archetypal allene propadiene, heteroallenes, and cyclic allenes, using density functional theory (DFT). The 1,3-dipolar cycloaddition reactivity of linear (hetero)allenes decreases as the number of heteroatoms in the allene increases and the formation of the 1,5-adduct is, in all cases, favored over the 1,4-adduct, both effects find their origin from the strength of the primary orbital interactions . The cycloaddition reactivity of cyclic allenes was also investigated, and the increased predistortion of allenes, that results upon cyclization, leads to systematically lower activation barriers not due to the expected variations in the strain energy, but instead from the differences in the interaction energy . The geometrical predistortion of cyclic allenes enhances the reactivity compared to linear allenes through a unique mechanism that involves a smaller HOMO-LUMO gap, which manifests into more stabilizing orbital interactions . © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.BACKGROUND The association between palatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) polymorphism and mortality is not well understood. We investigated the impact of PNPLA3 I148M (rs738409) polymorphism on overall and cardiovascular mortality based on the presence of NAFLD. METHODS The Third National Health and Nutrition Examination Survey (NHANES) from 1991 to 1994 and NHANES III-linked mortality data through 31 December 2015 were utilized in this study. RESULTS Of 4,814 participants, 50.7% were homozygous for the C-allele and 12.6% were homozygous for the G-allele. During a follow-up of 20 years, there were a total of 1,255 deaths, 422 attributed to cardiovascular disease. There was a significant association with overall mortality among those with the PNPLA3 I148M (rs738409) GG genotype (hazard ratio [HR] 1.34; 95% confidence interval [CI] 1.02-1.77) or G-allele (HR 1.22 95% CI 1.09-1.36) in the general population NAFLD with homozygous PNPLA3 I148M (rs738409) GG genotype had higher overall mortality after adjusting for multiple metabolic risk factors (hazard ratio [HR] 1.45; 95% confidence interval [CI] 1.01-2.08). The PNPLA3 I148M (rs738409) G-allele had a tendency of increased cardiovascular mortality in the total population. This association was not noted in those with NAFLD. CONCLUSIONS The homozygous PNPLA3 I148M (rs738409) GG genotype showed an increase in overall mortality in the general population and NAFLD independent of multiple metabolic risk factors. This article is protected by copyright. All rights reserved.OBJECTIVE There is much controversy about the neurobiological mechanisms underlying the effects of sleep-disordered breathing on the brain. The aim of this study was to investigate the association between markers of sleep-related hypoxemia and brain anatomy. METHODS We used data from a large-scale cohort from the general population (n = 775, 50.6% males, age range = 45-86 years, mean age = 60.3 ± 9.9) that underwent full polysomnography and brain MRI to correlate respiratory variables with regional brain volume estimates. RESULTS After adjusting for age, gender, and cardiovascular risk factors, only mean oxygen saturation during sleep was associated with bilateral volume of hippocampus (right p = 0.001; left p less then  0.001), thalamus (right p less then  0.001; left p less then  0.001), putamen (right p = 0.001; left p = 0.001) and angular gyrus (right p = 0.011; left p = 0.001). We observed the same relationship in left hemispheric amygdala (p = 0.010), caudate (p = 0.008), inferior frontal gyrus (p = 0.004) and supramarginal gyrus (p = 0.003). The other respiratory variables - lowest oxygen saturation, % of sleep time with oxygen saturation  less then  90%, apnea-hypopnea index and oxygen desaturation index - did not show any significant association with brain volumes. INTERPRETATION Lower mean oxygen saturation during sleep was associated with atrophy of cortical and subcortical brain areas known for high sensitivity to oxygen supply. Their vulnerability to hypoxemia may contribute to behavioral phenotype and cognitive decline in patients with sleep-disordered breathing. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.While the natural transition orbital (NTO) method has allowed electronic excitations from time-dependent Hartree-Fock and density functional theory to be viewed in a traditional orbital picture, the extension to multicomponent molecular orbitals such as those used in relativistic two-component methods or generalized Hartree-Fock (GHF) or generalized Kohn-Sham (GKS) is less straightforward due to mixing of spin-components and the inherent inclusion of spin-flip transitions in time-dependent GHF/GKS. check details An extension of single-component NTOs to the two-component framework is presented, in addition to a brief discussion of the practical aspects of visualizing two-component complex orbitals. Unlike the single-component analog, the method explicitly describes the spin and frequently obtains solutions with several significant orbital pairs. The method is presented using calculations on a mercury atom and a CrO2 Cl2 complex. © 2020 Wiley Periodicals, Inc.
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