Notes

Oleanolic acidity obstructs the actual purine save walkway regarding cancers therapy by simply inactivating SOD1 and stimulating lysosomal proteolysis.
Introduction Although often used in medicine, video consultations are less commonly used in dentistry. During the COVID-19 pandemic, the orthodontic team at Croydon University Hospital introduced the use of video consultations to provide continued patient care at a time when face-to-face appointments were not possible.Aim To assess patient and clinician satisfaction with the Attend Anywhere video consultations used by the orthodontic team at Croydon University Hospital.Method Two separate satisfaction questionnaires were piloted and developed one for patients and one for clinicians. All patients scheduled for a video consultation between 15 May 2020 and 15 June 2020 were invited to complete a patient satisfaction questionnaire at the end of their consultation.Results In total, 114 patients attended video consultations in the time period assessed, of which 111 completed a satisfaction questionnaire (97.4% response rate). Fifty-six percent of patients were female with an average age of 16.5 years. Patient satisfaction was highest for the video consultations being easy to use and convenient. Over 90% of patients strongly agreed or agreed with all of the satisfaction statements and in terms of whether they would recommend using video consultations. Approximately one-third of patients preferred the video consultation to a face-to-face appointment and one-third of patients were neutral.Conclusion This study found high levels of patient satisfaction with video consultations in orthodontics. Thoughtful consideration needs to be given to the application of video clinics, going forwards, to ensure that high standards of patient care are maintained.Aim This systematic review aimed to critically summarise the results of clinical studies investigating agents able to stop the progression of carious lesions; stop the development of new root carious lesions; preserve the vitality of the infected dental tissues; and increase the surface hardness or change of surface texture, in middle-age and older adults.Methods PubMed, Scopus, and Web of Science were searched systematically, following PRISMA guidelines. Clinical trials published from 2011 to 2020 (March) were included. This systematic review is registered in the PROSPERO database (CRD42018104399). Languages were restricted to English.Results Thirteen of 312 studies were eligible for this review. Eight agents were identified in the studies and their efficacy was assessed using different methods. The agents that presented valuable results on preventing or arresting root caries were 38% silver diamine fluoride (SDF), arginine-containing toothpaste and high-fluoride toothpastes.Conclusions Based on the selected studies' findings, annual applications of 38% SDF could be the most effective treatment for root caries in older adults. In addition, the daily use of a 1.5% arginine toothpaste or a high-fluoride toothpaste could also be recommended. More research on root caries-specific diagnostic methods, especially at very early stages, is necessary.Objective Access to transport is a common barrier to oral health. Greater dependence on public transport has shown delayed oral healthcare, lack of usual source of care and greater unmet health needs. GSK2334470 mw This study examined the spatial accessibility of the population of Great Britain to public transport in providing access to oral healthcare.Methods A total of 8,791 dental practices in Great Britain were identified and geocoded. There were 10,444 rail, metro and light rail stops and 348,961 bus and tram stops. Geographic information systems were utilised to integrate the dental practice locations and public transport points to respective census tracts of each nation containing population data, deprivation measures, and classification of rural and urban areas.Results Almost all dental clinics in Great Britain were located within 400 m of bus and tram stops or 800 m of a rail, metro or light rail stop. Similarly, in Scotland and England, 92% lived within any public transport (within 400m of bus and tram stops or 800m of a rail, metro or light rail stop), and in Wales, 84.2% lived within any public transport stop. However, only 75.1%, 79.6% and 60.4% of the population of Scotland, England and Wales had access to a high-frequency bus stop, respectively. In Scotland, England and Wales, 40.7%, 33.7% and 38.3% of rural residents did not have access to any public transport and only 4.9%, 7.5% and 14.6% of the rural residents had access to an optimal bus stop, respectively. In Wales, 19.5% of older adults do not have access to a bus stop.Conclusion Some transport-disadvantaged groups do not have adequate access to public transport services. There is a compelling need to address public transport integration with oral health facilities to ensure equality in accessing integral services.Introduction Due to a rising prevalence of removable partial denture (RPD) use, there is an unmet need to explore the psychological impact on patient wellbeing.Aim To assess the psychological effects of consumers losing teeth and receiving partial dentures to better manage their needs.Design Four market research surveys, undertaken on behalf of GlaxoSmithKline Consumer Healthcare, are described.Setting Surveys were conducted across the US, Japan, Malaysia, Colombia, Brazil, Poland and Italy.Materials and methods Quantitative/qualitative methods were used to gain knowledge regarding patients' experiences living with partial dentures.Results In a global market research survey involving 3,952 RPD wearers (RPDWs), 54% said that losing teeth was difficult to accept, 40% were concerned about their appearance, 32% were embarrassed about wearing dentures and 62% wished that more oral care education was available when they were younger. In another survey of >1,000 RPDWs, self-esteem was negatively impacted in 51% of respondents and 57% reported anxiety around dental visits.Conclusions Global market research confirmed that RPDWs can have emotional and practical needs that are not well understood/documented by dental healthcare professionals (HCPs). Consumer research can enhance understanding of patients' needs by dental HCPs and provide suggestions about how they may address them.Background The National Patient Safety Agency (2008) has advised against routine reliance on flumazenil for reversal of sedation and encourages regular audit to help identify issues with excessive dosing of midazolam. This multi-centre audit of flumazenil use across both community-based special care and dental hospital oral surgery specialist services was conducted to compare practice against that reported from other UK sedation services.Methods A six-year retrospective audit was conducted using controlled drug records and patient case notes.Results Both services used flumazenil at very infrequent levels and far below the agreed standard. The dose of flumazenil and justification for its use was recorded in all records. There was variability in the nature of the justifications between the two services, which likely relates to the differing patient groups seen by the specialties. The majority of cases related to supporting the patient's escort for their journey home; however, this was not always pre-planned.Conclusions There was a low level of flumazenil use over an extended period of time, supporting the concept of a culture of safe sedation provision in both services. The audit highlighted variation in record-keeping and need for improved communication with patients about escort requirements.Introduction Video consultations are currently not commonly used in dentistry; therefore, most clinicians lack experience in using this technology and seeing patients in this way. When implementing video clinics, it is important to assess clinician satisfaction as well as patient satisfaction to allow for developments and improvements, and to ensure that the highest levels of care are provided.Aim To assess patient and clinician satisfaction with the Attend Anywhere video consultations used by the orthodontic team at Croydon University Hospital.Method Two separate satisfaction questionnaires were piloted and developed one for patients and one for clinicians. For all patients scheduled for a video consultation between 15 May 2020 and 15 June 2020 in the orthodontic department, all clinicians were invited to complete a clinician satisfaction questionnaire at the end of the consultation to assess satisfaction with the encounter.Results In total, 114 patients attended video consultations, for which there were 128 clinician completed questionnaires, as some patients were seen by multiple clinicians on multidisciplinary clinics. Over 89% of clinicians strongly agreed or agreed with all of the satisfaction statements, with the highest levels of satisfaction being for ease of use and convenience. Over 95% of clinicians strongly agreed or agreed that they would recommend using video consultations and over 89% preferred using a video consultation, if appropriate, to a face-to-face appointment. Overall, the highest levels of satisfaction were for retainer reviews.Conclusion High levels of clinician satisfaction were found with the telemedicine clinics in orthodontics across a range of different appointment types and encounters. Satisfaction varied according to the type of appointment; therefore, this should be a factor for consideration when planning the most appropriate use of telemedicine clinics going forwards.Dysregulation of glucose homeostasis contributes to insulin resistance and type 2 diabetes. Whilst exercise stimulated activation of AMP-activated protein kinase (AMPK), an important energy sensor, has been highlighted for its potential to promote insulin-stimulated glucose uptake, the underlying mechanisms for this remain largely unknown. Here we found that AMPK positively regulates the activation of Rab5, a small GTPase which is involved in regulating Glut4 translocation, in both myoblasts and skeletal muscles. We further verified that TBC1D17, identified as a potential interacting partner of Rab5 in our recent study, is a novel GTPase activating protein (GAP) of Rab5. TBC1D17-Rab5 axis regulates transport of Glut1, Glut4, and transferrin receptor. TBC1D17 interacts with Rab5 or AMPK via its TBC domain or N-terminal 1-306 region (N-Ter), respectively. Moreover, AMPK phosphorylates the Ser 168 residue of TBC1D17 which matches the predicted AMPK consensus motif. N-Ter of TBC1D17 acts as an inhibitory region by directly interacting with the TBC domain. Ser168 phosphorylation promotes intra-molecular interaction and therefore enhances the auto-inhibition of TBC1D17. Our findings reveal that TBC1D17 acts as a molecular bridge that links AMPK and Rab5 and delineate a previously unappreciated mechanism by which the activation of TBC/RabGAP is regulated.Recombinant human growth hormone (r-hGH) is used as a therapeutic agent for disorders of growth including growth hormone deficiency (GHD) and Turner syndrome (TS). Treatment is costly and current methods to model response are inexact. GHD (n = 71) and TS patients (n = 43) were recruited to study response to r-hGH over 5 years. Analysis was performed using 1219 genetic markers and baseline (pre-treatment) blood transcriptome. Random forest was used to determine predictive value of transcriptomic data associated with growth response. No genetic marker passed the stringency criteria for prediction. However, we identified an identical set of genes in both GHD and TS whose expression could be used to classify therapeutic response to r-hGH with a high accuracy (AUC > 0.9). Combining transcriptomic markers with clinical phenotype was shown to significantly reduce predictive error. This work could be translated into a single genomic test linked to a prediction algorithm to improve clinical management. Trial registration numbers NCT00256126 and NCT00699855.
Website: https://www.selleckchem.com/products/gsk2334470.html