Notes

Nature-derived hit, guide, along with drug-like modest compounds: Existing status and future aspects towards important target meats involving Coronaviruses.
on several factors. However, the overall prognosis remains poor.
We aimed to identify the most suited anthropometric measure for the prediction of risk for incident coronary heart disease (CHD) among the Turkish population.

We collected data on body mass index, waist circumference (WC), hip circumference, waist-to-hip ratio (WHR), waist-to-height ratio (WHtR) and a body shape index. We analysed these using both C-statistics and Cox regression models adjusted for age, systolic blood pressure, glucose and high-density lipoprotein (HDL)-cholesterol for assessing risk of incident CHD among 3203 Turkish Adult Risk Factor (TARF) study participants (mean [SD] age 48.5 [11] years).

Over a mean follow-up of 9.93 years, new CHD developed in 573 individuals. Multi-adjusted C-statistics were highest for WHtR followed by WC, in both sexes. Except WHR, all measures were significantly associated with incident CHD in combined sexes in the full model. There was a sex difference, however, in the mediation of the three risk factors for adiposity; these attenuated hazard ratios (HRs) in males, whereas in females, significant prediction of incident CHD persisted for each measure. WC (HR 1.36 [95% CI 1.13; 1.64]), followed by WHtR (HR 1.24 [95% CI 1.10; 1.40]), were in combined sex, as in females, the most informative surrogates of adiposity. Hip circumference did not protect, but rather conferred modest CHD risk, especially in females, rendering a low utility of predictive value for WHR. The CHD risk curve did not have a J shape.

WC is the most suitable of five adiposity surrogates for CHD risk among Turkish adults, while in males, unmediated adiposity risk was similarly identified by WHtR. Retention of the large part of CHD risk in females perhaps reflects the underlying autoimmune activation.
WC is the most suitable of five adiposity surrogates for CHD risk among Turkish adults, while in males, unmediated adiposity risk was similarly identified by WHtR. Retention of the large part of CHD risk in females perhaps reflects the underlying autoimmune activation.
The National Programme for Control of Blindness and Visual Impairment modified the definition of blindness in 2017 in line with the internationally accepted definition. We did a systematic review and meta-analysis to compute pooled estimate of blindness in India among adults aged 50 years and above by using recent and old definitions of blindness.

We retrieved population-based studies/surveys reporting the prevalence of blindness using recent (presenting vision <3/60 better eye) and previous (presenting vision <6/ 60 better eye) definitions in India during 1990-2017 from key search engines and grey literature. Two authors did an independent literature search and extracted relevant information. Pooled prevalence estimates were computed using Stata 12.0 by using the random effects model. Forest and funnel plots were generated. Stratification of results was also performed using two time periods 1995-2005 and 2006-17.

A total of 18 published articles/reports were included for recent and 20 for previoue. High quantum of blindness remains an unfinished public health agenda for implementing programmes in larger populations to reduce its burden.
The objective of this study was to identify and validate smartphone-based visual acuity (VA) apps that can be used in a teleophthalmology portal.

The study was conducted in three phases A survey to investigate if the SmartOptometry App was easy to download, understand and test (phase I), an in-clinic comparison of VA measured in a random testing order with four tools namely COMPlog, Reduced Snellen near vision, Peek Acuity (Distance VA) and SmartOptometry (Near VA) (phase II) and a repeatability study on these 4 tools by measuring VA again (phase III). The study recruited the employees of our institute and adhered to the strict COVID-19 protocols of testing.

Phase I Survey (n = 40) showed 90% of participants used android phones, 60% reported that instructions were clear, and all users were able to self-assess their near VA with SmartOptometry App. Phase II (n = 68) revealed that Peek Acuity was comparable to COMPlog VA (P = 0.31), however SmartOptometry was statistically significantly different (within 2 log MAR lines) from Reduced Snellen near vision test, particularly for young (n = 44, P = 0.004) and emmetropic (n = 16, P = 0.04) participants. All the 4 tests were found to be repeatable in phase III (n = 10) with a coefficient of repeatability ≤0.14.

Smartphone-based apps were easy to download and can be used for checking patient's distance and near visual acuity. An effect of age and refractive error should be considered when interpreting the results. Further studies with real-time patients are required to identify potential benefits and challenges to solve.
Smartphone-based apps were easy to download and can be used for checking patient's distance and near visual acuity. An effect of age and refractive error should be considered when interpreting the results. Further studies with real-time patients are required to identify potential benefits and challenges to solve.
The aim of this study was to assess the impact of an audio visual (AV) teaching module on basic torchlight examination of the eye and direct ophthalmoscopy for undergraduate medical students.

This observational longitudinal study was done on 33 consecutive medical interns during their Ophthalmology posting from December 2019 to March 2020 at a medical college in South-India. An AV-module was created using animation graphics, narratives, demonstrations on normal individuals and on patients with positive signs. All interns had a pretest consisting of Multiple-choice questions, (MCQs) and an Objective Structured Clinical Examination (OSCE) on torchlight examination and direct ophthalmoscopy (DO). They were then shown the 20-minute AV-module. A posttest was performed immediately and after one week.

The mean pretest MCQ score was 5.84 ± 1.98. It improved to 8.81 ± 1.15 in the immediate posttest and 8.87 ± 1.66 in the one-week posttest. The mean pretest OSCE score was 12.21 ± 3.39. It improved to 23.21 ± 3.39f students are highly risk prone.
Several language variations of YANS have been published. There is a rationale in grouping languages where one variation is usable for several countries. The people of four ex-Yugoslavian countries do speak practically one language whatever its present name.

To make a Serbian version of YANS which would be usable in Serbia, Croatia, Bosnia and Herzegovina and Montenegro.

Translation and test-retest survey in a secondary school.

The translation process was performed according to the relevant guidelines through a standard procedure English-Serbian-English-Consensus (people fluent in English)-Pilot assessment (20 students). The survey was performed in a Belgrade high school. Test YANS was completed by 244 students (response rate 98,8%, males 44%). Retest YANS was carried out among 60 randomly chosen students from the primary sample (response rate 96.7%, males 58%). In the statistical analysis we used the Olsen's model of classification as well as previous validation of YANS. A reliability measure for analyzing survey items was Cronbach's alpha. Determination of the mean differences between test and retest with respect to normal distribution of data was performed with the Student's paired t-test.

Factor analysis between items grouped into four factors showed no significant association, except for a weak but negative one between two specific factors. The internal reliability (Cronbach's alpha) was 0.721 and assessed as acceptable. The test-retest comparison did not reveal any significant differences. Mean overall YANS score was 2.76, which is higher than on testing in Sweden, very similar to the Brazilian one, and lower than in Belgium and China.

Serbian version of YANS is a valid and reliable research instrument. It may also be used in Croatia, Bosnia and Herzegovina and Montenegro.
Serbian version of YANS is a valid and reliable research instrument. It may also be used in Croatia, Bosnia and Herzegovina and Montenegro.
Two aspects of noise annoyance were addressed in the present laboratory study (1) the disturbance produced by vehicle pass-by noise while engaging in a challenging non-auditory task, and (2) the evaluative response elicited by the same sounds while imagining to relax at home in the absence of a primary activity.

In Experiment 1, N = 29 participants were exposed to short (3-6 s) pass-by recordings presented at graded levels between 50 and 70 dB(A). Concurrent with each sound presentation, they performed a visual multiple-object tracking task, and subsequently rated the annoyance of the sounds on a VAS scale. In Experiment 2, N = 30 participants judged the sounds while imagining to relax, without such a cognitive task.

Annoyance was reduced when participants were engaged in the cognitively demanding task, in Experiment 1. Furthermore, when occupied with the task, annoyance slightly, but significantly increased with task load. Across both experiments, the magnitude of simultaneously recorded skin conductance responses in the first 1-4 s after the onset of stimulation increased significantly with sound pressure level. Annoyance ratings tended to be elevated across all sound levels, though significantly only in Experiment 2, in participants classified as noise sensitive based on a 52-item questionnaire.

The results suggest that noise annoyance depends on the primary activity the listener is engaged in. They demonstrate that phasic skin conductance responses may serve as an objective correlate of the degree of annoyance experienced. Finally, noise sensitivity is once more shown to augment annoyance ratings in an additive fashion.
The results suggest that noise annoyance depends on the primary activity the listener is engaged in. They demonstrate that phasic skin conductance responses may serve as an objective correlate of the degree of annoyance experienced. Finally, noise sensitivity is once more shown to augment annoyance ratings in an additive fashion.
In order to establish the acceptability of a hearing protector device (HPD) used in a given noisy environment, two key elements must be known with the highest possible accuracy the insertion loss of the HPD and the associated variability. Methods leading to objective field measurements of insertion loss have become widely available in the last decade and have started to replace the traditional subjective "Real-Ear Attenuation at Threshold" (REAT) laboratory measurements. The latter have long been known to provide a gross overestimate of the attenuation, thus leading to a strong underestimate of the worker's exposure to noise.

In this work we present objective measurements of the insertion loss of an ear plug, carried out using the E-A-Rfit procedure by 3M on a large sample of 36 female and 64 male subjects. buy CA77.1 This large number of independent measurements has been exploited to calculate the distribution function of effective noise levels, that is noise levels that take into account the use of the HPD. The knowledge of the distribution function has in its turn allowed the calculation of the uncertainty on the effective noise levels.

This new estimate of uncertainty (6 to 7 dB) is significantly larger than most previous estimates, which range between 4 and 5 dB when using objective data but with an improper uncertainty propagation, and around 3 dB when using REAT subjective data. We show that the revised new estimate of uncertainty is much more realistic as it includes contributions that are missed by the other methods.

By plugging this revised estimate of uncertainty into the criterion for checking the acceptability of the HPD, a better assessment of the actual protection provided by the HPD itself is possible.
By plugging this revised estimate of uncertainty into the criterion for checking the acceptability of the HPD, a better assessment of the actual protection provided by the HPD itself is possible.
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