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Delineating the Role regarding Mitophagy Inducers regarding Alzheimer Condition Sufferers.
The direct visualization and dynamics of anisotropic-strain-related domain ordering will open a new path toward the control and manipulation of domain engineering in strongly correlated perovskite oxide films.We report a unique naturally derived activated carbon with optimally incorporated nitrogen functional groups and ultra-microporous structure to enable high CO2 adsorption capacity. The coprocessing of biomass (Citrus aurantium waste leaves) and microalgae (Spirulina) as the N-doping agent was investigated by probing the parameter space (biomass/microalgae weight ratio, reaction temperature, and reaction time) of hydrothermal carbonization and activation process (via the ZnCl2/CO2 activation) to generate hydrochars and activated carbons, respectively, with tunable nitrogen content and pore sizes. The central composite-based design of the experiment was applied to optimize the parameters of the prehydrothermal carbonization procedure resulting in the fabrication of N-enriched carbonaceous products with the highest possible mass yield and nitrogen content. The resulting hydrochars and activated carbon samples were characterized using elemental analysis, X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, field emission scanning electron microscopy, and Brunauer-Emmett-Teller surface area analysis. We observe that while N-doping and the activation process can individually enhance the CO2 adsorption capacity to some extent, it is the combined effect of the two processes that synergistically work to greatly increase the adsorption capacity of the N-doped activated carbon by an amount which is more than the sum of individual contributions. We analyze the origins of this synergy with both physical and chemical characterization techniques. Lipopolysaccharides nmr The resulting naturally derived activated carbon demonstrates one of the highest CO2 adsorption capacities (8.43 mmol/g) with rapid adsorption kinetics and good selectivity and reusability.In recent years, bacteria inactivation during their direct physical contact with surface nanotopography has become one of the promising strategies for fighting infection. Contact-killing ability has been reported for several nanostructured surfaces, e.g., black silicon, carbon nanotubes, zinc oxide nanorods, and copper oxide nanosheets. Herein, we demonstrate that Gram-negative antibiotic-resistant Escherichia coli (E. coli) bacteria are killed as a result of their physical destruction while contacting nanostructured h-BN surfaces. BN films, made of spherical nanoparticles formed by numerous nanosheets and nanoneedles with a thickness 99% inactivation of colony forming units after 24 h, same as gentamicin-loaded (150 μg/cm2) BN sample. The BN films loaded with a mixture of gentamicin (150 and 300 μg/cm2) and amphotericin B (100 μg/cm2) effectively inhibit the growth of E. coli K-261 and Neurospora crassa strains. During immersion in the normal saline solution, the BN film generates reactive oxygen species (ROS), which can lead to accelerated oxidative stress at the site of physical cell damage. The obtained results are valuable for further development of nanostructured surfaces having contact killing, ROS, and biocide release abilities.The strongly correlated La0.67Sr0.33MnO3 (LSMO) thin films were deposited on the BaTiO3 (BTO) substrates to study the influence of temperature-dependent phase transition of BTO on the magnetic and electric transport properties of the LSMO films. Because of the large lattice mismatch between the LSMO and BTO substrates, the ultrathin LSMO film exhibits semiconducting transport behavior rather than the normal metal-insulator transition behavior. A Mn2+-O2--Mn3+ dominated double exchange interaction, which leads to a semiconducting to metallic transition behavior, was formed by the joint effect of the ion-liquid gating and phase transition of the BTO substrates. Our work shows a special way to modulate the conduction mechanism, which opens up a new field for further study of the magnetoelectric coupling of the LSMO/BTO heterostructures.Reconfigurable metasurfaces have shown their great potentials and are needed in multiple applications, such as radar, wireless communication systems, and security. To date, however, it is challenging to realize low-cost and simple reconfigurable and multifunctional metasurfaces. In this proposed work, we present a low-cost and simple multifunctional all-passive metasurface that achieves a self-switching characteristic relying on a modulating incident wave without additional supporting devices. As proof-of-principle application examples, we realize a prototype of the proposed all-passive metasurface with an antenna for radome applications, that can achieve self-switching operation between a high directional antenna at the transmitting mode, and radar absorbing structure and reflector at the receiving mode. The reported strategy will open up a new avenue for future smart devices and could extend to some smarter applications such as high-power pulse skin protection for electronic devices and self-reconfigurable beam switching metasurface.Langerhans cell histiocytosis (LCH) limited to the skin is rare in adult patients. Given the challenges of prospective clinical trials for this rare disease, there is paucity in data to guide the management of cutaneous LCH. Topical nitrogen mustard is a possible treatment for cutaneous LCH with positive responses in five known adult cases in the literature. In this report, we present two adult patients with recalcitrant cutaneous LCH and no evidence of systemic involvement who had rapid and complete response on topical nitrogen mustard therapy. We provide support for topical nitrogen mustard as a treatment option for primary cutaneous LCH which may spare patients from requiring systemic immunosuppressive treatments. J Drugs Dermatol. 2020;19(8)803-805. doi10.36849/JDD.2020.4943.Melasma is a chronic dermatologic condition with an incompletely understood pathogenesis and well-demonstrated impact on patient quality of life. Melasma is a common cause for seeking dermatologic care, and with no universally efficacious therapy or cure, com-bination treatment is the best approach for many cases. Numerous studies have demonstrated the role of oxidative stress in patients with melasma, prompting investigation into several antioxidants for melasma therapy. In this review, we discuss the well-defined role of oxidative stress in melasma and the therapeutic efficacy of various antioxidants for patients suffering from melasma. We focus our discussion on studies investigating the role of vitamin C, azelaic acid, cysteamine, glutathione, carotenoids, and numerous other antioxidants in disorders of hyperpigmentation. There is promising evidence for the use of these antioxidants, as topical, oral, and intra-venous preparations, both in isolation and in conjunction with other melasma therapies. J Drugs Dermatol. 2020;19(8)788-792. doi10.36849/JDD.2020.5079.Background The relationship between the clearance of psoriasis and improved quality of life together with an increased uptake of cosmetic procedures has not been reported to date. Objective A survey was conducted at a single dermatology center to determine if there was an increased trend in cosmetic procedures in patients with moderate to severe psoriasis who attained 75% or greater reduction of the body surface area (BSA) with biologic agents and oral systemic therapies, and if this was related to an improvement in quality of life following psoriasis clearance. Study Design In this case series, 138 patients with a history of moderate to severe psoriasis who attained 75% or greater body surface area (BSA) reduction with biologic agents or oral systemic therapies and had undergone at least one cosmetic procedure in the past 2 years were surveyed. Patient characteristics were collected including age, sex, percent BSA at initiation of therapy, the class of biologic or oral systemic therapies, and the different trocedures. J Drugs Dermatol. 2020;19(8) doi10.36849/JDD.2020.5104R1.Calcipotriene 0.005% plus betamethasone dipropionate 0.064% (Cal/BD) aerosol foam is a topical agent indicated for the treatment of plaque psoriasis. While topical treatments are typically reserved for milder disease, in clinical trials with Cal/BD foam, the vast majority of patients had beyond-mild psoriasis at baseline, and multiple studies (including subgroup analyses from randomized controlled trials and other small-scale studies) have demonstrated favorable outcomes with the use of Cal/BD foam in this population. The objective of this article is to review existing data on the efficacy, safety, and cost-effectiveness of Cal/BD foam used in patients with beyond-mild psoriasis, either alone as topical monotherapy or as adjunctive therapy. Practical recommendations for managing beyond-mild psoriasis with Cal/BD foam are also provided. J Drugs Dermatol. 2020;19(8) doi10.36849/JDD.2020.5300.Background Neonates and infants are susceptible to skin barrier disruption as their skin anatomically and functionally is still developing. The process of skin acidification plays a vital role in barrier maturation and the activation of enzymes involved in the extracellular processing of stratum corneum lipids. The current consensus paper explores challenges, and current treatment approaches in neonatal and infant normal and sensitive skin and the role of ceramides containing moisturizers. Methods For this purpose, an expert panel of pediatric dermatologists and dermatologists discussed information from systematic literature searches, coupled with expert opinion and experience of the panel, to adopt eight statements. The consensus process consisted of a modified Delphi technique. Results During the first years after birth, the neonatal and infant skin is more permeable to topical agents and, therefore, requires particular caution with topical skincare regimens. Mildly acidic or pH-neutral cleansers have benefits for neonates and infants. Skincare for neonates and infants should be safe, effective, and fragrance free as well as sensitizing agent-free. Additionally, the skincare should be pleasant to use, containing ingredients that benefit the lipid and water content of the SC, such as those products containing ceramides. Conclusion Taking into consideration the maturation process of neonatal and infant skin, the application of moisturizers and cleansers containing barrier lipids may help maintain the protective skin barrier and soothe with long-term moisturizing benefits. J Drugs Dermatol. 2020;19(8) 769-776 doi10.36849/JDD.2020.5252 THIS ARTICLE HAD BEEN MADE AVAILABLE FREE OF CHARGE. PLEASE SCROLL DOWN TO ACCESS THE FULL TEXT OF THIS ARTICLE WITHOUT LOGGING IN. NO PURCHASE NECESSARY. PLEASE CONTACT THE PUBLISHER WITH ANY QUESTIONS.Introduction Psoriasis is a chronic, immune-mediated skin disease that is associated with sex-related differences. Two double-blind, vehicle-controlled, phase 3 studies evaluated halobetasol propionate (HP) 0.01% lotion for the treatment of moderate-to-severe localized plaque psoriasis; pooled post hoc analyses investigated efficacy and safety in male and female subgroups. Methods Participants were randomized (21) to once-daily HP or vehicle lotion for 8-weeks of double-blind treatment, with a 4-week posttreatment follow-up. Post hoc efficacy assessments in male (n=253) and female (n=177) subgroups included treatment success (≥2‑grade improvement in Investigator's Global Assessment [IGA] score and score of 'clear' or 'almost clear'), treatment success in psoriasis signs (erythema, plaque elevation, and scaling) at the target lesion, and change in affected body surface area (BSA). Treatment-emergent adverse events (TEAEs) were evaluated. Results At week 8, rates of IGA-rated treatment success were significantly greater for HP versus vehicle in males (34.
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