Notes

An integrative transcriptome review discloses Ddit4/Redd1 as being a crucial regulator of cancer malignancy cachexia throughout rat models.
implantation of VigilanS we found an acceleration of the reduction of stay for suicide attempt in Nord et Pas-de-Calais after 2014(-16% instead of -6%), instead of the two Picardy departments the most comparable show a degradation of the phenomenon (+13%). The system is currently being deployed across France.Identifying and taking care of the suicidal risk the concern for others. The suicidal crisis is a period of rupture in the existence of an individual, marked by psychic suffering and tension, the major risk of which being suicide. The diagnostic and therapeutic intervention of the clinician can be made complex by the clinical presentation specific to each individual and the ambivalence of these patients. In this article, we propose ways to identify and evaluate the suicidal crisis, with semio logical elements, and criteria for assessing risk, urgency and dangerousness (RUD). We also provide support for the assessment of the suicidal crisis, with the notions of respect, listening, understanding, and questions to bein cluded in the evaluation of suicidal thoughts and intentions. These elements must make it possible to rigorously evaluate the suicide potential and to help the therapeutic decision, in order to bring the most adapted intervention to these patients.Current modeling of suicidal behavior crisis, transition, and vulnerability. Bay 11-7085 cell line Suicidal behavior is multifactorial and polymorphic. Modeling - although simplifying - is necessary. This article presents three interactive processes the suicidal crisis, the transition from ideas to action, and the suicidal vulnerability. The suicidal crisis is a state of rupture of the psychic balance, often occurring in response to an event of social and interpersonal character, and leading the individual to the significant thoughts that only suicide is the solution to one's own problems. This crisis is particularly marked by an unbearable psychic pain whose cessation is the goal of most suicidal gestures. The acting out occurs in less than a quarter of people with suicidal ideas. The mechanisms responsible for the emergence of suicidal ideation appear partly different from those allowing the transition to a suicidal act. Suicidal risk in a context of psychosocial stress is increased by the existence of vulnerability factors, whose complex nature is developmental, genetic, cognitive, and temperamental, among others.Suicidal behaviors in France still a public health issue. In 2015, 9,109 deaths by suicide were counted in France, representing 13.7 suicides per 100,000 inhabitants. This rate has been declining for 30 years as in many countries. A significant underestimation is however suggested for various reasons. The risk of suicide is three times higher for men than for women. Suicide rates increase among those over 75 years of age, mostly for men, while the highest suicide frequencies are found among those aged 35-65, and suicide is the second leading cause of death among adolescents and young adults. More than half of suicides are by hanging. Suicide attempts are 10 to 20 times more frequent than suicide, about 100 to 200,000 acts each year, and are also decreasing over the last years. In 2017, 88,712 hospitalizations for suicide attempts were recorded in France. Suicide attempts are associated with an increased risk of death, by suicide in particular, but also by somatic disease. The prevalence of suicidal ideation, appreciated through surveys in the general population, is high, estimated at about 5%. Many suicidal risk factors have been identified with a recognized lack of individual predictive ability. These data are crucial for guiding prevention actions and measuring their effects.Medical liability until when? A doctor who commits a fault in the exercise of his activity is likely to be held liable several years after his patient has been cared for. While civil and criminal liabilities are subject to limitation periods, disciplinary action against a liberal health professional is imprescriptible. The possibility of litigation several years after the harmful event requires health professionals to adapt their policies on the storage of medical records, which constitute a central means of proof in the event of litigation.Surface modification of nonlinear optical materials (NOMs) is widely applied to fabricate diverse photonic devices, such as frequency combs, modulators, and all-optical switches. In this work, a double-layer nanostructure with heterogeneous nanoparticles (NPs) is proposed to achieve enhanced third-order optical nonlinearity of NOMs. The mechanism of modified optical nonlinearity is elucidated to be the scattering-induced energy transfer between adjacent NPs layers. Based on the LiNbO3 platform, as a typical example, double layers of embedded Cu and Ag NPs are synthesized by sequential ion implantation, demonstrating twofold magnitude of near-infrared enhancement factor and modulation depth in comparison with a single layer of Cu NPs. With the elastic collision model and thermolysis theory being considered, the shift of the localized surface plasmon resonance (LSPR) peak reveals the formation mechanism of the double-layer nanostructure. Utilizing the enhanced optical nonlinearity of LiNbO3 as modulators, a Q-switched mode-locked waveguide laser at 1 µm is achieved with shorter pulse duration. It suggests potential applications to improve the performance of nonlinear photonic devices by using double-layer metallic nanostructures.Cell adhesion of nanosystems is significant for efficient cellular uptake and drug delivery in cancer therapy. Herein, a near-infrared (NIR) light-driven biomimetic nanomotor is reported to achieve the improved cell adhesion and cellular uptake for synergistic photothermal and chemotherapy of breast cancer. The nanomotor is composed of carbon@silica (C@SiO2 ) with semi-yolk@spiky-shell structure, loaded with the anticancer drug doxorubicin (DOX) and camouflaged with MCF-7 breast cancer cell membrane (i.e., mC@SiO2 @DOX). Such biomimetic mC@SiO2 @DOX nanomotors display efficient self-thermophoretic propulsion due to a thermal gradient generated by asymmetrically spatial distribution. Moreover, the MCF-7 cancer cell membrane coating can remarkably reduce the bioadhesion of nanomotors in biological medium and exhibit highly specific self-recognition of the source cell line. The combination of effective propulsion and homologous targeting dramatically improves cell adhesion and the resultant cellular uptake efficiency in vitro from 26.2% to 67.5%. Therefore, the biomimetic mC@SiO2 @DOX displays excellent synergistic photothermal and chemotherapy with over 91% MCF-7 cell growth inhibition rate. Such smart design of the fuel-free, NIR light-powered biomimetic nanomotor may pave the way for the application of self-propelled nanomotors in biomedicine.Direct tracing of small extracellular vesicle (sEV) cargoes holds unprecedented importance for elucidating the mechanisms involved in intercellular communication. However, high-fidelity determination of sEVs' molecular cargoes in situ has yet to be achieved due to the difficulty in transporting molecular probes into intact sEVs. Herein, a fLuorescent Intracellular-Guided Hairpin-Tetrahedron (fLIGHT) nanoprobe is described for direct visualization of sEV microRNAs in situ. Integrating the advantages of nondestructive sEV penetration via DNA origami and single-nucleotide discrimination as well as wash-free fluorescence readout using a hairpin probe, the proposed approach enables high-fidelity fluorescence visualization of sEVs' microRNA without RNA extraction or leakage, demonstrating the potential of on-site tracing of sEV cargoes. This strategy opens an avenue to establishing universal molecular detection and labeling platforms that can facilitate both sEV-derived fundamental biological studies and molecular diagnostics.The distance between the surface of the scalp and the surface of the grey matter of the brain is a key factor in determining the effective dose of non-invasive brain stimulation for an individual person. The highly folded nature of the cortical surface means that the depth of a particular brain area is likely to vary between individuals. The question addressed here is what is the variability of this measure of cortical depth? Ninety-four anatomical MRI images were taken from the OASIS database. For each image, the minimum distance from each point in the grey matter to the scalp surface was determined. Transforming these estimates into standard space meant that the coefficient of variation could be determined across the sample. The results indicated that depth variability is high across the cortical surface, even when taking sulcal depth into account. This was true even for the primary visual and motor areas, which are often used in setting TMS dosage. The correlation of the depth of these areas and the depth of other brain areas was low. The results suggest that dose setting of TMS based on visual or evoked potentials may offer poor reliability, and that individual brain images should be used when targeting non-primary brain areas.The pandemic of coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected more than 19.7 million persons worldwide with 7 28 013 deaths till August 10, 2020. It has put an unprecedented workload on healthcare systems with special reference to labor rooms and obstetrics as deliveries cannot be stopped or postponed. Preparing their facilities using triage (COVID-positive patients, COVID-suspect patients, and COVID-negative patients) can help to better utilize the limited resources and help in prevention of spread of disease, and improve maternal and perinatal outcome. There is a need for proper training of healthcare providers for judicious use of personal protective equipment (PPE) for optimum outcome. Fortunately, the available literature suggests that there is no substantial increased risk of acquiring COVID-19 in pregnancy or its increased virulence in pregnancy and labor and there are no adverse effects on fetus and neonate with negligible fetal transmission rate. Nevertheless, utmost care is needed to manage such pregnancies, their prenatal care, and labor. This review aimed to highlight the main recommendations applied in Indian maternities for better management of pregnancy during the COVID-19 pandemic.Type 2C protein phosphatases (PP2Cs) are the largest protein phosphatase family. PP2Cs dephosphorylate substrates for signaling in Arabidopsis, but the functions of most PP2Cs remain unknown. Here, we characterized PP2C49 (AT3G62260, a Group G PP2C), which regulates Na+ distribution under salt stress and is localized to the cytoplasm and nucleus. PP2C49 was highly expressed in root vascular tissues and its disruption enhanced plant tolerance to salt stress. Compared with wild type, the pp2c49 mutant contained more Na+ in roots but less Na+ in shoots and xylem sap, suggesting that PP2C49 regulates shoot Na+ extrusion. Reciprocal grafting revealed a root-based mechanism underlying the salt tolerance of pp2c49. Systemic Na+ distribution largely depends on AtHKT1;1 and loss of function of AtHKT1;1 in the pp2c49 background overrode the salt tolerance of pp2c49, resulting in salt sensitivity. Furthermore, compared with plants overexpressing PP2C49 in the wild-type background, plants overexpressing PP2C49 in the athtk1;1 mutant background were sensitive to salt, like the athtk1;1 mutants.
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