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ion, pejorative language, and patronizing attitudes that can lead to discriminatory actions, such as the limited provision of lifesaving supports and health services for people with dementia during the pandemic. COVID-19 policies and public health messages should focus on precautions and preventive measures rather than labeling specific population groups.
In this study, wepropose an automatic diagnostic algorithm for detecting otitis media based on wideband tympanometry measurements.

We develop a convolutional neural network for classification of otitis media based on the analysis of the wideband tympanogram. Saliency maps are computed to gain insight into the decision process of the convolutional neural network. Finally, we attempt to distinguish between otitis media with effusion and acute otitis media, a clinical subclassification important for the choice of treatment.

The approach shows high performance on the overall otitis media detection with an accuracy of 92.6%. However, the approach is not able to distinguish between specific types of otitis media.

Out approach can detect otitis media with high accuracy and the wideband tympanogram holds more diagnostic information than the commonly used techniques wideband absorbance measurements and simple tympanograms.

This study shows how advanced deep learning methods enable automatic diagnosis of otitis media based on wideband tympanometry measurements, which could become a valuable diagnostic tool.
This study shows how advanced deep learning methods enable automatic diagnosis of otitis media based on wideband tympanometry measurements, which could become a valuable diagnostic tool.Brain disease diagnosis is a new hotspot in the cross research of artificial intelligence and neuroscience. Quantitative analysis of functional magnetic resonance imaging (fMRI) data can provide valuable biomarkers that contributes to clinical diagnosis, and the analysis of functional connectivity (FC) has become the primary method. However, previous studies mainly focus on brain disease classification based on the low-order FC features, ignoring the potential role of high-order functional relationships among brain regions. To solve this problem, this study proposed a novel multi-level FC fusion classification framework (MFC) for brain disease diagnosis. We firstly designed a deep neural network (DNN) model to extract and learn abstract feature representations for the constructed low-order and high-order FC patterns. Both unsupervised and supervised learning steps were performed during the DNN model training, and the prototype learning was introduced in the supervised fine-tuning to improve the intra-class compactness and inter-class separability of the feature representation. Then, we combined the learned multi-level abstract FC features and trained an ensemble classifier with a hierarchical stacking learning strategy for the brain disease classification. Systematic experiments were conducted on two real large-scale fMRI datasets. Results showed that the proposed MFC model obtained robust classification performance for different preprocessing pipelines, different brain parcellations, and different cross-validation schemes, suggesting the effectiveness and generality of the proposed MFC model. Overall, this study provides a promising solution to combine the informative low-order and high-order FC patterns to further promote the classification of brain diseases.Automatic spine and vertebra segmentation from X-ray spine images is a critical and challenging problem in many computer-aid spinal image analysis and disease diagnosis applications. In this paper, a two-stage automatic segmentation framework for spine X-ray images is proposed, which can firstly locate the spine regions (including backbone, sacrum and ilium) in the coarse stage and then identify eighteen vertebrae (i.e., cervical vertebra 7, thoracic vertebra 1-12 and lumbar vertebra 1-5) with isolate and clear boundary in the fine stage. A novel Attention Gate based dual-pathway Network (AGNet) composed of context and edge pathways is designed to extract semantic and boundary information for segmentation of both spine and vertebra regions. Multi-scale supervision mechanism is applied to explore comprehensive features and an Edge aware Fusion Mechanism (EFM) is proposed to fuse features extracted from the two pathways. Some other image processing skills, such as centralized backbone clipping, patch cropping and convex hull detection are introduced to further refine the vertebra segmentation results. Experimental validations on spine X-ray images dataset and vertebrae dataset suggest that the proposed AGNet achieves superior performance compared with state-of-the-art segmentation methods, and the coarse-to-fine framework can be implemented in real spinal diagnosis systems.Acupuncture can regulate the functions of human body and improve the cognition of brain. However, the mechanism of acupuncture manipulations remains unclear. Here, we hypothesis that the frontal cortex plays a gating role in information routing of brain network under acupuncture. To that end, the gating effect of frontal cortex under acupuncture is analyzed in combination with EEG data of acupuncture at Zusanli acupoints. In addition, recurrent neural network (RNN) is used to reproduce the dynamics of frontal cortex under normal state and acupuncture state. From low-dimensional view, it is shown that the brain networks under acupuncture state can show stable attractor cycle dynamics, which may explain the regulation effect of acupuncture. Comparing with different manipulations, we find that the attractor of low-dimensional trajectory varies under different frequencies of acupuncture. this website Besides, a strip gated band of neural dynamics is found by changing the frequency of stimulation and excitatory-inhibitory balance of network. This reverse engineering of brain network indicates that the differences among acupuncture manipulations are caused by interaction and separation in the neural activity space between attractors that encode acupuncture function. Consequently, our results may provide help for quantitative analysis of acupuncture, and benefit for the clinical guidance of acupuncture clinicians.Synthetic digital twins based on medical data accelerate the acquisition, labelling and decision making procedure in digital healthcare. A core part of digital healthcare twins is modelbased data synthesis, which permits the generation of realistic medical signals without requiring to cope with the modelling complexity of anatomical and biochemical phenomena producing them in reality. Unfortunately, algorithms for cardiac data synthesis have been so far scarcely studied in the literature. An important imaging modality in the cardiac examination is three-directional CINE multislice myocardial velocity mapping (3Dir MVM), which provides a quantitative assessment of cardiac motion in three orthogonal directions of the left ventricle. The long acquisition time and complex acquisition produce make it more urgent to produce synthetic digital twins of this imaging modality. In this study, we propose a hybrid deep learning (HDL) network, especially for synthetic 3Dir MVM data. Our algorithm is featured by a hybrid UNet and a Generative Adversarial Network with a foreground-background generation scheme. The experimental results show that from temporally down-sampled magnitude CINE images (six times), our proposed algorithm can still successfully synthesise high temporal resolution 3Dir MVM CMR data (PSNR=42.32) with precise left ventricle segmentation (DICE=0.92). These performance scores indicate that our proposed HDL algorithm can be implemented in real-world digital twins for myocardial velocity mapping data simulation. To the best of our knowledge, this work is the first one in the literature investigating digital twins of the 3Dir MVM CMR, which has shown great potential for improving the efficiency of clinical studies via synthesised cardiac data.Traumatic Brain Injury (TBI) is caused by a head injury that affects the brain, impairing cognitive and communication function and resulting in speech and language disorders. Over 80,000 individuals in the US suffer from long-term TBI disabilities and continuous monitoring after TBI is essential to facilitate rehabilitation and prevent regression. Prior work has demonstrated the feasibility of TBI monitoring from speech by leveraging advancements in Artificial Intelligence (AI) and speech processing technology. However, much of prior work explored TBI detection using scripted speech tasks such as diadochokinesis tests or reading a passage. Such scripted approaches require active user involvement that significantly burdens participants. Moreover, they are episodic, are not realistic, and do not provide a longitudinal picture of the user's TBI condition. This study proposes a continuous TBI monitoring from changes in acoustic features of spontaneous speech collected passively using the smartphone. Low-level acoustic features are extracted using parametrized Sinc filters (pSinc) that are then classified TBI (yes/no) using a cascading Gated Recurrent Unit (cGRU). The cGRU model utilizes a cell gate unit in the GRU to store and incorporate each individual's prediction history as prior knowledge into the model. In rigorous evaluation, our proposed method outperformed prior TBI classification methods on conversational speech recorded during patient-therapist discourses following TBI, achieving 83.87% balanced accuracy. Furthermore, unique words that are important in TBI prediction were identified using SHapley Additive exPlanations (SHAP). A correlation was also found between features acquired by the proposed method and coordination deficits following TBI.MicroRNAs play an important role in gene regulation for many biological systems, including nicotine and alcohol addiction. However, the underlying mechanism behind miRNAs and mRNA interaction is not well characterized. Microarrays are commonly used to quantify the expression levels of mRNAs and/or miRNAs simultaneously. In this study, we performed a Bayesian network analysis to identify mRNA and miRNA interactions following perinatal exposure to nicotine and/or alcohol. We utilized three sets of microarray data to predict the regulation relationship between mRNA and miRNAs. Following perinatal alcohol exposure, we identified two miRNAs miR-542-5p and miR-874-3p, that exhibited a strong mutual influence on several mRNA in gene regulatory pathways, mainly Axon guidance and Dopaminergic synapses. Finally, we confirmed our predicted addiction pathways based on the Bayesian network analysis with the widely used Kyoto Encyclopedia of Genes and Genomes (KEGG)-based database and identified comparable relevant miRNA-mRNA pairs. We believe the Bayesian network can provide insight into the complexity biological process related to addiction and can potentially be applied to other diseases.High-performance and reliable control of systems that are highly dynamic and open-loop unstable is challenging but of considerable practical interest. Thus, this article investigates the performance optimization and fault tolerance of highly dynamic systems. First, an incremental control structure is proposed, where a controller gain system is attached to the predesigned controller, and by reconfiguring the controller gain system, the performance can be equivalently optimized as configuring the predesigned one. The incremental attachment of the controller gain system does not modify the existing control system, and it can be easily attached via various communication channels. Second, a structure integrating fault-tolerance strategy and hardware redundancy is proposed. Under this structure, command fusion and fault-tolerance strategies are developed where the control commands from different control units are optimally fused, and each control unit can be reconfigured w.r.t. the performance of the other ones. Furthermore, Q-learning algorithms are developed to realize the proposed structures and strategies in real-time model-freely.
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