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CONCLUSION Spraying schedules are good predictors of environmental contamination. Monitoring of residues remains essential to determine the real residue concentration in the topsoil. SSDs proved valuable. It was inferred that in addition to the standard test with the earthworm Eisenia fetida (Savigny, 1826), an arthropod test organism such as Folsomia candida (Willem, 1902) should be used in future risk assessments because it displays higher sensitivity towards insecticides. © 2020 Society of Chemical Industry.OBJECTIVE To describe the efficacy of in-series hemoperfusion and hemodialysis in 2 dogs with carprofen overdose. CASE SUMMARY This report describes the treatment of 2 dogs following accidental carprofen overdoses who underwent a single in-series hemoperfusion and hemodialysis session. Serial serum carprofen concentrations were measured before, during, and after the session. The first patient's session lasted 5 hours, with the largest decrease in serum carprofen concentrations occurring during the first hour of treatment. The carprofen clearance during the following 4 hours of treatment decreased substantially compared to the first hour and was not different from the patient's intrinsic clearance of carprofen after the session was completed. Based on the findings from the first case, the second patient was treated with a 1 hour single hemoperfusion and hemodialysis session. Our results support the hypothesis that carprofen is not effectively removed by conventional hemodialysis and the efficacy of hemoperfusioal filter should be considered. © Veterinary Emergency and Critical Care Society 2020.Nanographenes (NGs), also known as graphene quantum dots, have recently been developed as nanoscale graphene fragments. These nanocarbon species can be excited with UV light and emit light from the UV-to-visible region. This photoemission has received great attraction across multiple scientific fields. NGs can be produced by cutting off carbon sources or fusing small organic molecules to grow graphitic structures. Furthermore, the organic synthesis of NGs has been intensely studied. Recently, the number of research papers on postsynthetic modifications of NGs has gradually increased. Installed organic groups can tune the properties of NGs and provide new functionalities, opening the door for the development of sophisticated carbon-based functional materials. This review sheds light on recent progress in the postsynthetic modification of NGs and provides a brief summary of their production methods. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Li-air batteries are limited to lab-scale research owing to the uninterrupted formation of discharge products. In the case of Li-CO2 batteries, the increase in overpotential caused by Li2 CO3 formation results in cell death. In this study, Cu2 O crystals having three different types of shapes (i.e., cubic, octahedral, and rhombic) were synthesized to compare their catalytic activity toward CO2 reactions. The full-cycle and long-term stability test revealed that rhombohedral Cu2 O facilitates Li2 CO3 decomposition more efficiently than that of cubic and octahedral Cu2 O. The cycle was extended to investigate the photocatalytic activity of the rhombic Cu2 O by illuminating the cell. The repeated cycles to 1 h showed a maximum overpotential of 1.5 V, which is 0.5 V lower than that of the cell without illumination. A postmortem analysis of the cell after dividing the cycles into segments demonstrated interesting results concerning the role of light and Cu2 O during the cell cycle. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.Revealing the spatial scaling patterns of microbial diversity is of special interest in microbial ecology. One critical question is whether the observed spatial turnover rate truly reflect the actual spatial patterns of extremely diverse microbial communities. Using simulated mock communities, this study suggested that the currently observed microbial spatial turnover rates were overestimated by random sampling processes associated with high-throughput metagenomic sequencing. The observed z values were largely contributed by accumulated microbial taxa due to cumulative number of samples. This is a crucial issue because microbial communities already have very low spatial turnover rate due to the small size and potential cosmopolitism nature of microorganisms. Further investigations suggested a linear relationship between the observed and expected z values, which can be applied to remove random sampling noises from the observed z values. Adjustment of z values for data sets from six American forests showed much lower spatial turnover rate than that before adjustment. However, the patterns of z values among these six forests remained unchanged. This study suggested that our current understanding of microbial taxa-area relationships could be inaccurate. Therefore, cautions and efforts should be made for more accurate estimation and interpretation of microbial spatial patterns. © 2020 Society for Applied Microbiology and John Wiley & Sons Ltd.Looking times and gaze behavior indicate that infants can predict the goal state of an observed simple action event (e.g., object-directed grasping) already in the first year of life. The present paper mainly focuses on infants' predictive gaze-shifts toward the goal of an ongoing action. For this, infants need to generate a forward model of the to-be-obtained goal state and to disengage their gaze from the moving agent at a time when information about the action event is still incomplete. By about 6 months of age, infants show goal-predictive gaze-shifts, but mainly for familiar actions that they can perform themselves (e.g., grasping) and for familiar agents (e.g., a human hand). Therefore, some theoretical models have highlighted close relations between infants' ability for action-goal prediction and their motor development and/or emerging action experience. Recent research indicates that infants can also predict action goals of familiar simple actions performed by non-human agents (e.g., object-directed grasping by a mechanical claw) when these agents display agency cues, such as self-propelled movement, equifinality of goal approach, or production of a salient action effect. This paper provides a review on relevant findings and theoretical models, and proposes that the impacts of action experience and of agency cues can be explained from an action-event perspective. In particular, infants' goal-predictive gaze-shifts are seen as resulting from an interplay between bottom-up processing of perceptual information and top-down influences exerted by event schemata that store information about previously executed or observed actions. © 2020 The Authors. Topics in Cognitive Science published by Wiley Periodicals, Inc. on behalf of Cognitive Science Society.BACKGROUND The oriental fruit fly, Bactrocera dorsalis (Hendel), is a widespread agricultural pest that has evolved resistance to many commonly used insecticides including malathion. Glutathione S-transferases (GSTs) are multifunctional enzymes that metabolize insecticides directly or indirectly. The specific mechanism used by GSTs to confer malathion resistance in B. dorsalis is unclear. RESULTS BdGSTd9 was identified from B. dorsalis and was expressed at twice the level in a malathion-resistant strain (MR) than in a susceptible strain (MS). By using RNAi of BdGSTd9, the toxicity of malathion against MR was increased. Protein modelling and docking of BdGSTd9 with malathion and malaoxon indicated key amino acid residues for direct binding in the active site. In vitro assays with engineered Sf9 cells overexpressing BdGSTd9 demonstrated lower cytotoxicity of malathion. High performance liquid chromatography (HPLC) analysis indicated that malathion could be broken down significantly by BdGSTd9, and it also could deplete the malathion metabolite malaoxon, which possesses a higher toxicity to B. dorsalis. Taken together, the BdGSTd9 of B. dorsalis could not only deplete malathion, but also react with malaoxon and therefore enhance malathion resistance. CONCLUSION BdGSTd9 is a component of malathion resistance in B. dorsalis. It acts by depleting both malathion and malaoxon. © 2020 Society of Chemical Industry. © 2020 Society of Chemical Industry.The purpose of this study was to develop a predictive model for perceived competence and to obtain an integrator evaluation of the nursing curriculum with measures of nursing self-efficacy, general self-efficacy, resilience, and stress among nursing students. A correlational study with nursing students (N = 265) from the degree in nursing was conducted. A factor analysis was used to test the construct validity of nursing self-efficacy and perceived competence. The correlational and discriminant analyses evaluated the factors in the four academic levels of the degree (2016-2017) to identify the variables involved in the classification of the students in each level. The results of exploratory and confirmatory factor analyses of nursing self-efficacy and perceived competence revealed a statistically significant good fit and consistency. Nursing self-efficacy, general self-efficacy, resilience, and year of the degree course predicted 34% of perceived competence scores. The discriminant function of nursing self-efficacy, perceived competence, and resilience classified 76% of participants in the first and last years of the degree. Nursing self-efficacy, perceived competence, and resilience increased with academic level. They help chart nursing students' progress through the curriculum. © 2020 John Wiley & Sons Australia, Ltd.OBJECTIVE This study assessed prevalence of Connective Tissue Disease (CTDs), Systemic Lupus Erythematosus (SLE), antiphospholipid syndrome (APS) and antiphospholipid antibodies (aPL) in women with previous adverse pregnancy outcome compared to uncomplicated livebirths. DESIGN Retrospective case-control study. SETTING UK Primary Care. POPULATION OR SAMPLE Records of women, 18 years and older, within the Clinical Practice Research Datalink (CPRD), (01/01/2000-31/12/2013). METHODS CPRD was searched for pregnancy terms to identify adverse pregnancy outcome. Each identified case was matched to 5 livebirths. read more MAIN OUTCOME MEASURES Diagnosis of SLE, CTD, APS or autoimmune antibodies. Poisson regression was performed to calculate relative risk ratios (RR), comparing adverse pregnancy outcome to livebirth cohorts. RESULTS CPRD identified 20,123 adverse pregnancy outcomes matched to 97,323 livebirths, with a total of 875,590 person-years follow-up. Median follow-up from study entry was 7.29 years (SD 4.39). Compared to women with an uncomplicated livebirth, women with adverse pregnancy outcome had increased risk of developing CTD or autoimmune antibodies (RR 3.20, CI 2.90-3.51). Risk was greatest following a stillbirth (RR 5.82 (95% CI 4.97, 6.81)). For CTD and SLE, the risk was greatest within the first 5 years of adverse pregnancy outcome. Risk for aPL and APS diagnosis was highest ≥ 5 years from adverse pregnancy outcome. CONCLUSIONS Adverse pregnancy outcome is associated with increased risk of developing maternal CTD, including SLE. Either immunological factors predispose women to adverse pregnancy outcome and subsequent CTD diagnosis, or alternatively, adverse pregnancy outcome initiates autoimmune events which culminate in CTD in later-life. This article is protected by copyright. All rights reserved.
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