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The present study provides a new perspective about the effect of dietary glucogenic to lipogenic ingredient ratios on rumen metabolism by comparing end-products, gas production and bacterial composition via an in vitro technique.
The present study provides a new perspective about the effect of dietary glucogenic to lipogenic ingredient ratios on rumen metabolism by comparing end-products, gas production and bacterial composition via an in vitro technique.
Acne scars are common problems encountered in daily dermatologic practice.

To evaluate the effectiveness and safety of 25% trichloroacetic acid (TCA) alone or followed by manual dermasanding in repeated sessions for the treatment of mild and moderate acne scars.

Thirteen patients (nine females and four males) were enrolled. Twenty-five percent TCA superficial peel was performed in all patients, followed in 11 of them by manual dermasanding. Thirteen sessions of TCA peeling, one session for each patient, were done, and twenty-four sessions of dermasanding with different numbers for each patient. Acne scars were graded into a score ranging from 0 to 20, the score was recorded at each visit, and the results were compared.

The score of scarring acne decreased after TCA peeling and each dermasanding session. The improvement was statistically significant. The improvement continued after the last dermasanding session. After both procedures, no significant complications were recorded except persistent erythema and post-inflammatory hyperpigmentation, which disappeared in all patients at 3-month follow-up visit.

Trichloroacetic acid superficial peel followed by manual dermasanding in separate sessions was effective and the improvement became more significant after repeated dermasanding sessions for the treatment of mild and moderate acne scars.
Trichloroacetic acid superficial peel followed by manual dermasanding in separate sessions was effective and the improvement became more significant after repeated dermasanding sessions for the treatment of mild and moderate acne scars.
Clearance of hepatitis C virus (HCV) is associated with improved glycometabolic control in patients with diabetes mellitus (DM) but whether this effect is maintained over the long term with a reduction in liver-related events (LRE) is still debated. To address these issues, we conducted a long-term prospective study on diabetic and non-diabetic patients with chronic hepatitis C cured by direct antiviral agents (DAAs).

Among 893 recruited patients, 15.7% were diabetic (Group 1) and 84.3% non-diabetic (Group 2); changes in fasting glucose (FG) and glycated haemoglobin (HbA1c) levels were assessed in Group 1 while the incidence of LRE was established in the whole cohort. Differences between groups were evaluated and independent predictors of unfavourable clinical outcome were established.

After a mean follow up of 44.5months, a significant reduction in FG and HbA1c values was found in Group 1. Death was reported in 5.7% of patients in Group 1 vs 1.6% in Group 2 (P=.003), hepatocellular carcinoma (HCC)-free survival was significantly lower in Group 2 (P=.015) as well as LRE-free survival in Group 1 cirrhotic patients (P=.0006). After adjustment for baseline variables, cirrhosis and albumin levels emerged as independent predictors of LRE; low albumin levels, DM and central obesity were associated with HCC risk in cirrhotic patients while insulin therapy emerged as unfavourable predictor among diabetics.

SVR achieved by DAAs is associated with long-term improvement of glycometabolic control in diabetic patients, but among cirrhotics DM still exerts a detrimental effect on the liver.
SVR achieved by DAAs is associated with long-term improvement of glycometabolic control in diabetic patients, but among cirrhotics DM still exerts a detrimental effect on the liver.
To investigate periodontitis as a risk factor for prevalent and incident coronary heart disease (CHD) in a group of middle-aged men from Northern Ireland.

A representative sample of 1400 dentate men had a comprehensive periodontal examination between 2001 and 2003. Prevalent and incident CHD events were validated by independent cardiologists. Logistic regression was used to assess the cross-sectional relationship between periodontitis and prevalent CHD and Cox's proportional hazards analysis to assess the longitudinal relationship between periodontitis and incident CHD.

The mean age of the men at baseline was 63.7 (SD 3.0)years. Of the 1400 men examined, 126 (9%) had prevalent CHD. After adjusting for confounding variables, men with highest mean CAL (Q4) had an odds ratio of 2.15 (95% CI 1.15-4.02), p=0.02 for prevalent CHD in comparison to men with the lowest CAL (Q1). During a median follow-up of 12.7years, 137 (10.8%) of the 1274 men free of CHD at baseline had an incident CHD event. After adjusting for confounding variables, the hazard ratio for incident CHD in men in Q4 versus Q1 CAL categories was 1.36 (95% CI 0.81-2.29), p=0.24.

In this group of dentate men, periodontitis was associated with prevalent CHD. However, there was no association with incident CHD.
In this group of dentate men, periodontitis was associated with prevalent CHD. However, there was no association with incident CHD.
Patients with cirrhosis have a poor health-related quality of life (HRQoL). Recognizing factors that affect HRQoL is key in delivering patient-centred care.

To identify factors most commonly associated with a poor HRQoL in adults with cirrhosis in a systematic review of the literature.

Four databases (MEDLINE, EMBASE, CENTRAL and PsycINFO) were searched from inception to March 2020, using terms related to patient-reported outcomes plus cirrhosis. Studies that analysed an association between at least one factor and HRQoL in adult patients with cirrhosis were included. Abstract and full-text screening was performed by two reviewers. Data were collected on factors evaluated in each study and the significance of their association with HRQoL.

A total of 10647 citations were reviewed, of which 109 met eligibility criteria. 76% of the studies used a generic instrument while only 45% used liver-specific instruments. Liraglutide clinical trial Among identified factors, demographic factors and cirrhosis aetiology were not generally associated with poor HRQoL except for poor social support.
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