Notes

Reduction involving Diurnal (9AM-4PM) IOP Fluctuations together with Minimally Invasive Glaucoma Surgical treatment: An Examination of information in the Future, Multicenter, Single-Arm GEMINI Research.
5%, to M4 - in 16.7%, to M5 - in 7,2%. The degree of recovery of sensitivity to S0-S2 was observed in 36.2%, to S3 - in 42.8%, to S4 - in 17.4%, to S5 - in 3.6%. Selleckchem Aloxistatin Regression of pain syndrome after surgery was observed in 81.2% of patients.

Conclusions The results of surgical treatment of peripheral nerves gunshot injury are generally worse than other types of nerve injuries. link2 The best results of surgical treatment of combat trauma of peripheral nerves are obtained in patients with sciatic nerve damage.
Conclusions The results of surgical treatment of peripheral nerves gunshot injury are generally worse than other types of nerve injuries. The best results of surgical treatment of combat trauma of peripheral nerves are obtained in patients with sciatic nerve damage.
The aim of this work was to experimentally study the modifying role of toxic substances (phenol) in the manifestation of genotoxic and immunological changes in the body when exposed to a carcinogen (benzo[a]pyrene).

Materials and methods Investigations were carried out in the chronic experiment on white random-bred male mice. Genotoxic (micronucleus test), immunologic and pathomorphological methods were used.

Results As a result of the experiment on white outbred mice during the isolated peroral administration of benzo[a]pyrene (a single dose of 0.1 mg) and in combination with phenol (single doses of 0.1 mg; 0.002 mg) a carcinogenic effect (forestomach papillomas) has been established as well as general patterns of the manifestation of genotoxic and immunological changes regarding carcinogenesis and their dependence on the dose and duration of the administration of the substances in the early stages of the experiment. The established patterns involved parallelism of development and unidirectionality of the genotoxic effect (increasing of micronucleus incidence) and suppression of the T-cell immunity by the end of the month as well as reliable negative correlation between them.

Conclusions It has been established that phenol has a modifying effect on carcinogenesis, which was shown as an increase in the micronuclei frequency, intensification of immunosuppression in the early stages and an increase in the multiplicity factor of the development of forestomach tumors.
Conclusions It has been established that phenol has a modifying effect on carcinogenesis, which was shown as an increase in the micronuclei frequency, intensification of immunosuppression in the early stages and an increase in the multiplicity factor of the development of forestomach tumors.
The aim Is to investigate the impact of sports games (football) on the level of somatic health and emotional state of students in the process of studying.

Materials and methods The study was conducted at Kharkiv State Academy of Physical Culture and Sumy State University (Ukraine) in 2018-2019. The study involved 87 male students of the main department. Two groups were formed an experimental group (EG, n=42), the students of which were engaged in a sports-oriented form of physical education (in the class of football), and a control group (CG, n=45), the students of which were training according to the traditional methods of organizing physical education classes at higher education institutions. The somatic health of students was assessed according to the method of H. L. Apanasenko, which provided for the determination of body mass, life, power, and Robinson indexes, heart rate recovery time after a standard exercise. The emotional state of students was determined by the WAM (Well-being, Activity, Mood) mefe and help to improve future professional activities.
Conclusions It was found that sports games classes, including football, had a positive effect on the level of somatic health and emotional state of students. Significant changes were observed in the performance of the respiratory and cardiovascular systems of students. The high level of somatic health and good emotional state of students will help to improve mastering academic disciplines at higher education institutions, provide preparation for active life and help to improve future professional activities.
The aim Study of the indicators of quality of life of patients served by a multidisciplinary health care institution with the functionally-organizational model of coded prevention of chronic noninfectious diseases is implemented.

Materials and methods To evaluate the effectiveness of the model's use we used the assessment of the dynamics of QL indices, which was assessed according to the EUROHISQOL 8-item index methodology among 376 patients aged over 18 years.

Results Most of the respondents (61.4%) were dissatisfied to varying degrees with their state of health and, on average, evaluated their QL (56.1%). ЗThe overall assessment of the quality of life of the surveyed population was on a 20-point scale of 13.5 (3.19) points in 2017 before the introduction of the program of managed prevention of СNCDs and 14.6 (3.48) points after its three-year operation, with an increase integrated indicator on average by 1.1 (95% CI 0.59 - 1.60) points (p <0.001). Among the areas of QOL assessment, the assessments -communicable diseases, showed that the introduction of a functional-organizational model of managed prevention at the health care institution level can improve integrated assessment of QOL and positively affect the overall complex of medical and social factors, including managed risk factors. This indicates the effectiveness of this model of managed prevention at the level of a multidisciplinary health care institution.
The aim To study the incidence and mortality from gastric cancer in Europe and Ukraine.

Materials and methods Using statistical and medico-epidemiological methods, the analysis of the database of the National Cancer Registry of Gastric Cancer and Global cancer statistics 2018.

Results Gastric cancer remains an important cancer worldwide and is responsible for over 1,000,000 new cases in 2018 and an estimated 783,000 deaths, making it the fifth most frequently diagnosed cancer and the third leading cause of cancer death. Among men, it is the most commonly diagnosed cancer and the leading cause of cancer death in several countries of Europe, including Ukraine. Incidence rates are markedly elevated in Central/Eastern Europe, whereas the rates in Northern Europe are generally low. In the dynamics of the last decade, the primary incidence of gastric cancer has shown a tendency to decrease, as in Ukraine, from 25.5 per 100 thousand population in 2010 to 19.5 similar cases in 2019, which is -23.5% visibility) and in the Chernivtsi region (on -22.3% visibility). In Ukraine, as well as in Europe, the incidence and mortality of gastric cancer in men is 2 times higher than in women.

Conclusions Incidence and mortality rates have declined in Europe in the past decades. Trends in the ten-year dynamics of reducing the incidence and mortality of gastric cancer in Ukraine prove the effectiveness and feasibility of introducing preventive measures at the state level in the future.
Conclusions Incidence and mortality rates have declined in Europe in the past decades. link3 Trends in the ten-year dynamics of reducing the incidence and mortality of gastric cancer in Ukraine prove the effectiveness and feasibility of introducing preventive measures at the state level in the future.
The aim Is to present and substantiate approaches to the organization of radiation diagnostics training using cloud services.

Materials and methods The experimental research was carried out at on 306 students of the Bogomolets National Medical University. To perform the set tasks, some theoretical and empirical methods of scientific research were used, namely system analysis method, bibliosemantic method, statistical method, modeling method.

Results The expediency of building a hybrid digital environment, which combines the capabilities of the corporate and public cloud service and allows one to create an information system of personalized access to electronic educational resources was justified. This environment is implemented within the cloud service Nextcloud. The basic components of radiological diagnostics training by means of network technologies are considered and characterized. An experimental test of the effectiveness of the cloud services use is conducted in the process of training radiological diagnostics.

Conclusions The expediency of creating a modern digital educational environment based on the Nextcloud service for training radiological diagnostics has been justified. Moreover, it is demonstrated that pedagogically balanced and reasoned introduction of cloud services in the educational process promotes increased efficiency of educational process of radiological diagnostics.
Conclusions The expediency of creating a modern digital educational environment based on the Nextcloud service for training radiological diagnostics has been justified. Moreover, it is demonstrated that pedagogically balanced and reasoned introduction of cloud services in the educational process promotes increased efficiency of educational process of radiological diagnostics.
The aim Identifying the components of availability of Primary Health Care (PHC) and integration between PHC and secondary Health care (SHC) which need strengthening to reduce the rate of Ambulatory Care Sensitive Hospitalizations (ACSH) in Ukraine.

Materials and methods The study was conducted in two stages the focus of interviewing experts on the list of components of the availability of PHC and its integration with SHC; survey of our questionnaire is based on the results of the first stage of the study. The responses of 93 respondents - 20 experts and 73 general practitioners/family doctors - were analyzed using descriptive and analytical statistics.

Results There were identified 14 components of PHC availability and 8 integration components of PHC with SHC, their quantitative value (in points) of impact on ACSH. The informativeness of components is confirmed by the agreement of opinions of experts on their list (concordance coefficient W = 0.75 -0.87; p <0.01) and the reliable correlations of scores of impact assessments of the identified components with overall values of the impact availability PHC and the integration between PHC and SHC on the ACSH.

Conclusions The results of the study can be used to develop an action plan for reform of PHC, the implementation of which will reduce rates hospitalizations of Ambulatory care sensitive conditions and increase the efficiency use of limited resources of health care system of Ukraine.
Conclusions The results of the study can be used to develop an action plan for reform of PHC, the implementation of which will reduce rates hospitalizations of Ambulatory care sensitive conditions and increase the efficiency use of limited resources of health care system of Ukraine.
The aim Our aim was to assess the hemostatic potential of patients with liver cirrhosis and atrial fibrillation by LPTEG global coagulation assay, to investigate changes in LPTEG parameters according to the stage of liver cirrhosis and compare results with liver cirrhosis group.

Materials and methods We performed a prospective cross-sectional study including 70 patients with liver cirrhosis and atrial fibrillation, 36 patients with liver cirrhosis and 20 healthy individuals. LPTEG parameters were measured using ARP-01M "Mednord" in order to assess coagulation abnormalities.

Results t1 and Intensity of contact coagulation didn't differ (p>0,05), Constant of thrombin activity was increased (47.53±0.8vs.34.51±1.88, p<0.001), t3 was reduced (5,0±0.1vs.6.7±0.36 p<0.001), Intensity of coagulation drive was increased (52.8±1.8vs.38.55±1.54, p = 0.001), Intensity of clot polymerization was increased (19.66±0.28vs.16.29±0.28,p<0.001), time t5 was reduced (32.94±0.36 vs. 36.8±1.30, p<0.01), Maximum amplitude was increased (655.
Website: https://www.selleckchem.com/products/Aloxistatin.html