Notes

Within-person method to study the dependency recovery process of women.
The authors wish to make the following correction to this paper [...].The aim of this study was to examine the cross-sectional association between fish and shellfish intake and impaired glucose metabolism with consideration for cooking methods in a Japanese working population. Participants were 1774 workers aged 18-69 years. Dietary intake was assessed using a validated self-administered diet history questionnaire. Participants were asked about their most frequently used cooking method for fish, and the method was classified as either "raw and stewing" or "broiling, deep-frying, and stir-frying". Impaired glucose metabolism was defined by a history of diabetes, current use of anti-diabetic drugs, fasting blood glucose ≥110 mg/dl, or HbA1c ≥6.0%. Logistic regression analysis was used to estimate the odds ratios of impaired glucose metabolism for fish intake by cooking method. Fish intake was not associated with impaired glucose metabolism in either group. When the outcome was defined as diabetes, the odds of diabetes increased with fish intake among participants who most frequently used broiling, deep-frying, or stir-frying methods, albeit they were not statistically significant; the multivariable-adjusted odds ratio for the highest versus the lowest tertiles of fish intake was 1.95 (95%CI, 0.71-5.41). Cooking methods for fish may not modify the association between fish intake and impaired glucose metabolism among Japanese populations.This paper describes a problem related to a casting bridge crane with a combined load of 200/50/12.5 t and a span of 18.6 m, working in a heavy metallurgical operation. Due to the specific stress of the structure after its long-term operation, longitudinal fillet welds between the upper flange and the web of the main box beam on the rail side of the 200 t trolley were irreparably damaged. As a result, the cross-section of the main beam had opened, thereby substantially reducing its strength and stiffness. Onametostat cost This resulted in a disproportionate increase and undesirable redistribution of stresses in the beam and, at the same time, an increase in the probability of acute fatigue or the loss of stability of the elastic beam shape. Therefore, the rectification of the damaged load-bearing structure was carried out by specific structural modifications. Critical load-bearing elements were subjected to complicated strength and fatigue life analyses before and after rectification. These analyses were supported by experimental measurements. The applied modifications resulted in a partial strengthening of the lifting device with the possibility of its further operation, but only in a limited mode, with a limited period of operation with a time limit of 2 years and a reduced total load capacity of 150 t. The applied methods are also applicable for the fatigue analysis of load-bearing elements and equipment for bridge, gantry and tower cranes, crane tracks, road and railway bridges and support structures under machinery and other devices with a dominant transverse and rotating effect.Visual tracking is a fundamental vision task that tries to figure out instances of several object classes from videos and images. It has attracted much attention for providing the basic semantic information for numerous applications. Over the past 10 years, visual tracking has made a great progress, but huge challenges still exist in many real-world applications. The facade of a target can be transformed significantly by pose changing, occlusion, and sudden movement, which possibly leads to a sudden target loss. This paper builds a hybrid tracker combining the deep feature method and correlation filter to solve this challenge, and verifies its powerful characteristics. Specifically, an effective visual tracking method is proposed to address the problem of low tracking accuracy due to the limitations of traditional artificial feature models, then rich hiearchical features of Convolutional Neural Networks are used to make the multi-layer features fusion improve the tracker learning accuracy. Finally, a large number of experiments are conducted on benchmark data sets OBT-100 and OBT-50, and show that our proposed algorithm is effective.Fibrosis, the thickening and scarring of injured connective tissue, leads to a loss of organ function. Multiple cell types, including T-cells, macrophages, fibrocytes, and fibroblasts/myofibroblasts contribute to scar formation via secretion of inflammatory factors. This event results in an increase in oxidative stress and deposition of excessive extracellular matrix (ECM), characteristic of fibrosis. Further, aging is known to predispose connective tissue to fibrosis due to reduced tissue regeneration. In this study, we investigated the anti-fibrotic activity of a flowable placental formulation (FPF) using a bleomycin-induced dermal fibrosis model in aged mice. FPF consisted of placental amnion/chorion- and umbilical tissue-derived ECM and cells. The mice were injected with either FPF or PBS, followed by multiple doses of bleomycin. Histological assessment of FPF-treated skin samples revealed reduced dermal fibrosis, inflammation, and TGF-β signaling compared to the control group. Quantitative RT-PCR and Next Generation Sequencing analysis of miRNAs further confirmed anti-fibrotic changes in the FPF-treated group at both the gene and transcriptional levels. The observed modulation in miRNAs was associated with inflammation, TGF-β signaling, fibroblast proliferation, epithelial-mesenchymal transition and ECM deposition. These results demonstrate the potential of FPF in preventing fibrosis and may be of therapeutic benefit for those at higher risk of fibrosis due to wounds, aging, exposure to radiation and genetic predisposition.Tendinopathy is a rare but serious complication of quinolone therapy. Risk factors associated with quinolone-induced tendon disorders include chronic kidney disease accompanied by the accumulation of uremic toxins. Hence, the present study explored the effects of the representative uremic toxins phenylacetic acid (PAA) and quinolinic acid (QA), both alone and in combination with ciprofloxacin (CPX), on human tenocytes in vitro. Tenocytes incubated with uremic toxins +/- CPX were investigated for metabolic activity, vitality, expression of the dominant extracellular tendon matrix (ECM) protein type I collagen, cell-matrix receptor β1-integrin, proinflammatory interleukin (IL)-1β, and the ECM-degrading enzyme matrix metalloproteinase (MMP)-1. CPX, when administered at high concentrations (100 mM), suppressed tenocyte metabolism after 8 h exposure and at therapeutic concentrations after 72 h exposure. PAA reduced tenocyte metabolism only after 72 h exposure to very high doses and when combined with CPX. QA, when administered alone, led to scarcely any cytotoxic effect.
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