Notes

Applying regarding Metabolism Heterogeneity regarding Glioma Employing MR-Spectroscopy.
Clinical nurses should pay attention to the prevention and management of pressure injuries in critically ill adult patients. The approach should be selected and applied according to the specific clinical situation and the individual situation of each patient to achieve better treatment effect.
Clinical nurses should pay attention to the prevention and management of pressure injuries in critically ill adult patients. find protocol The approach should be selected and applied according to the specific clinical situation and the individual situation of each patient to achieve better treatment effect.
Many studies have demonstrated that acupuncture combined with Chinese herbal medicine (CHM) effectively treats knee osteoarthritis (KOA), with few side effects. However, few systematic reviews have offered evidence-based support. Here we conducted a meta-analysis on the combination of acupuncture with CHM in treating KOA.

Databases including CNKI, Wanfang, VIP, PubMed, EMBASE, and Cochrane library were systematically searched for articles on the treatment of KOA by acupuncture combined with CHM from the establishment of the database to May 2021. Three researchers independently searched, screened, extracted, and included articles that met the inclusion standards. The primary outcome measure was overall response rate (ORR), and the secondary outcome measures included Visual Analogue Scale (VAS) score, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and Lysholm score. ORR was a binary variable, while other indicators were continuous variables. The quality of literature was assesher-quality studies.
Compared with acupuncture alone or CHM/Western drug alone, acupuncture combined with CHM can effectively alleviate knee pain, improve knee function, and increase the quality of life. Thus, this combination can be used as a conservative treatment for KOA. However, due to the small number of high-quality articles and possible biases in our analysis, our conclusions need to be further verified in more and higher-quality studies.
The etiology and pathogenesis of cough are complex. As a Chinese patent medicine that has been on the market, ErtongKe (ETK) granules have a good effect in treating acute and chronic cough in children. The purpose of this research was to determine the bioactive components and possible action mechanisms of ETK in the treatment of cough using an integrated network pharmacology method.

The Traditional Chinese Medicine Systems Pharmacology (TCMSP) and Swiss target prediction databases were used to screen the potential components and associated targets of ETK. The Genecards database was then used to gather targets interacting with cough. An analysis of the signaling pathways associated with ETK for cough treatment was carried out using the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) enrichment analysis methods. Cytoscape 3.8.1 was used to design the protein-protein interaction (PPI) and compound-target-pathway networks. Finally, the important genes and active components of ETKpotential antitussives.
This research established that ETK exerts anti-cough activity by modulating several targets and pathways through multiple components. Additionally, the pooled results shed light on ETK compounds being investigated as potential antitussives.
This meta-analysis was performed to evaluate the clinical efficacy and safety of Chinese patent medicines in the treatment of subacute thyroiditis (SAT).

Chinese databases were searched using a combination of "patent Chinese medicine", "traditional Chinese medicine", "traditional Chinese and western medicine", "sub-thyroiditis", and "subacute thyroiditis". Studies that set Chinese patent medicine treatment of SAT as the experimental group were selected. Then, meta-analysis was performed by RevMan 5.3.

A total of 12 studies were included, and most of them had a high risk of bias (low quality). The heterogeneity test results of clinical efficacy showed that Chi2=6.21, df=7, P=0.52>0.1, and I2=0%<50%. Then, the fixed effects model (FEM) was used, with OR =2.80; 95% confidence interval (CI) 1.89-4.13. The heterogeneity test of recurrence rate showed that Chi2=10.69, df=9, P=0.30>0.1, and I2=16%<50%. The heterogeneity test of erythrocyte sedimentation rate showed that I2=97%, P<0.00001, MD =-1vels of free triiodothyronine and free thyroid hormone, and have good safety.
Several studies have evaluated the association between thermal insulation (TI) and control after surgery, with various research designs, recruitment and exclusion criteria, and measurements. The current meta-analysis aimed to assess the correlation between TI and stroke during recovery from anesthesia.

We searched for full-text articles of us of TI during anesthesia recovery in multiple databases including PubMed, Springer, EMBASE and Chinese journal full-text databases. Two reviewers read each article and extracted the relevant data of into a Microsoft Excel table name of the first author, publication year, year of onset, sample size (TI/control group), patient age range, and other information related to TI patients and control group. The meta-analysis, sensitivity analysis and bias analysis were performed using Review Manager 5.0.

A total of 723 patients from 7 studies met the eligibility criteria and were included in the final analysis. The meta-analysis showed that the recovery time after anesthesia in the TI group was significantly different from that in the control group [mean difference (MD) =-7.02, 95% confidence interval (CI) -10.10 to -3.95, P<0.00001; P for heterogeneity <0.00001, I2=99%], length of stay in Postanesthesia Care Unit (PACU) score [MD =-20.78, 95% CI -31.32 to -10.24, P=0.0001; P for heterogeneity <0.00001, I2=92%] and shivering rate [relative risk (RR) =0.25, 95% CI 0.08 to 0.77, P=0.02; P for heterogeneity =0.07, I2=71%].

TI is an important measure during recovery from anesthesia.
TI is an important measure during recovery from anesthesia.
This study sought to evaluate the cost-effectiveness of a pertuzumab, trastuzumab, and docetaxel (PTD) regimen and a trastuzumab and docetaxel (TD) regimen in the first-line treatment of human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) in the context of the Chinese health system.

A 3 health-state Markov model was established to simulate the disease process of patients. Transition probability and adverse reactions data were derived from the CLEOPATRA trial. The utility value of the disease status was derived from the relevant literature, and the costs were based on the China Drug Database and other local charges. Sensitivity analyses were performed to assess the uncertainty of the results caused by parameter variability.

Compared to the TD regimen, the PTD regimen afforded an additional 0.64 quality-adjusted life-years (QALYs) at an incremental cost of 44,828 USD. The incremental cost-effectiveness ratio (ICER) was 69,702 USD/QALY. The results of the sensitivity analysis suggest that the results are reliable.

The PTD regimen can prolong the life of patients and improve their quality of life with HER2-positive MBC, but the medical costs also increase accordingly. Based on the current payment threshold in China, the PTD regimen has no economic advantage over the TD regimen in the first-line treatment of HER2-positive MBC patients.
The PTD regimen can prolong the life of patients and improve their quality of life with HER2-positive MBC, but the medical costs also increase accordingly. Based on the current payment threshold in China, the PTD regimen has no economic advantage over the TD regimen in the first-line treatment of HER2-positive MBC patients.
Dizziness is a common symptom in clinic, but there lacks an effective treatment method. This study sought to examine the efficiency of deep learning (DL)-based magnetic resonance imaging (MRI) in the diagnosis of cerebral infarction mainly manifesting as vertigo using the neutrophil to lymphocyte ratio (NLR) and other routine blood indexes.

An improved multiscale U-Net [MS (U-Net)] model, based on the U-net model, was proposed and applied in the segmentation of MRI of the brain. One hundred and fifteen vertiginous cerebral infarction (VCI) patients, admitted to the Department of Neurology at Huizhou Central People's Hospital from January 2016 to December 2020, were chosen as the research subjects. Based on the MRI segmentation results for the brain, the patients were allocated to the benign paroxysmal positional vertigo (BPPV) group or acute cerebral infarction (ACI) group. Additionally, 50 healthy individuals, whose venous blood was collected for routine blood analyses, were allocated to the control group.

The MS (U-Net) model accomplishes MRI segmentation of the brain, and its segmentation results were much closer to the real results than those of the U-Net model. Compared to the control group, the monocyte count (MC), low-density lipoprotein/high-density lipoprotein (LDL/HDL) ratio, and NLR of patients in the BPPV and ACI groups showed an obvious increase (P<0.05), as did the white blood cell count, triglyceride (TG) level, and other indexes of ACI patients (P<0.05). In relation to the diagnosis, the areas under the curve for the TG level, LDL/HDL ratio, and NLR of the BPPV and ACI groups were 0.930 and 0.760, 0.900, and 0.770, 0.945 and 0.855, respectively (P<0.05).

DL can accomplish MRI segmentation in cerebral infarction patients, and the TG level, LDL/HDL ratio and NLR can be used in the diagnosis of VCI.
DL can accomplish MRI segmentation in cerebral infarction patients, and the TG level, LDL/HDL ratio and NLR can be used in the diagnosis of VCI.
Candida central nervous system (CNS) infection is a rare complication following neurosurgery. This disease often occurs during the treatment of bacterial CNS infection, and common bacterial culture results have a high false negative rate, which delays diagnosis and treatment, and seriously affect the prognosis of patients. The purpose of this study was to discuss the diagnosis, treatment process, and results of this disease through a small series of cases, so as to provide data support and a theoretical basis for the timely diagnosis and treatment of Candida CNS infection after neurosurgery.

A retrospective analysis was conducted on eight patients with confirmed Candida CNS infection following neurosurgery in our department between June 2011 and June 2019. Their clinical symptoms, treatment schemes, outcomes, risk factors, and complications were analyzed.

Four patients received intravenous administration of fluconazole and were cured. Three patients received intravenous administration of amphotericin B.ly diagnosis and timely use of antifungal agents are considered the primary treatment principles. Blood culture of cerebrospinal fluid (CSF) is useful for early diagnosis. Fluconazole is the preferred choice for the clinical treatment of Candida CNS infection as it has both good efficacy and safety.
Candida CNS infection following neurosurgery is a rare condition; however, it may result in disastrous consequences. Early diagnosis and timely use of antifungal agents are considered the primary treatment principles. Blood culture of cerebrospinal fluid (CSF) is useful for early diagnosis. Fluconazole is the preferred choice for the clinical treatment of Candida CNS infection as it has both good efficacy and safety.
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