Notes

Curcumin reduces the arecoline-induced fibrosis associated with dental mucosal fibroblasts through suppressing HIF-1α/TGF-β/CTGF signaling path: a good inside vitro study.
The sensors were embedded at the thumb, index finger, and back of the hand of the prosthetic hand. First, recognition tests involving tapped part were conducted. Then, recognition and realistic rating tests involving operations were conducted. Results showed high recognition of tapped parts and operations and the good realistic.This paper outlines the construction, current state, and future goals of HERCULES, a three degree-of-freedom (DoF) pneumatically actuated exoskeleton for stroke rehabilitation. The exoskeleton arm is capable of joint-angle control at the elbow in flexion and extension, at the shoulder in flexion and extension, and at the shoulder in abduction and adduction. In the near future we plan to embed kinematic synergies into the control system architecture of this arm to gain dexterous and near-natural movements.Clinical Relevance- This device can be used as an upper limb rehabilitation testbed for individuals with complete or partial upper limb paralysis. In the future, this system can be used to train individuals on synergy-based rehabilitation protocols.Upper limb prosthesis users currently lack haptic feedback from their terminal devices, which significantly limits their ability to meaningfully interact with their environment. Users therefore rely heavily on visual feedback when using terminal devices. Previously, it has been shown that force-related feedback from an end-effector or virtual environment can help the user minimize errors and improve performance. Currently, myoelectric control systems enable the user to control the velocity of terminal devices. We have developed a novel control method using ultrasound sensing, called sonomyography, that enables position control based on mechanical deformation of muscles. In this paper, we investigated whether the proprioceptive feedback from muscle deformation combined with vibrotactile haptic feedback can minimize the need for visual feedback. Able bodied subjects used sonomyography to control a virtual cursor, and performed a target acquisition task. The effect of visual and haptic feedback on performance of a target acquisition task was systematically tested. We found that subjects made large errors when they tried to reacquire a target without visual feedback, but in the presence of real-time haptic feedback, the precision of the target position improved, and were similar to when visual feedback was used for target acquisition. This result has implications for improving the performance of prosthetic control systems.In the current research of prosthetic hands, many degrees of freedom have been omitted in order to simplify the design and reduce the weight, such as the abduction degrees of freedom of the four fingers except the thumb, which impairs the range of mobility of the prosthetic hand to some extent. This paper presents TN hand, a 3D printed, tendon-driven prosthetic hand. We use continuum structure as the finger joint. The other four fingers except the middle finger can perform flexion/extension and abduction/adduction movements, which benefits hand mobility. The design and manufacture of the fingers were elaborated and the finger stiffness was tested through experiment. Then the ability of manipulating daily objects of TN hand was verified based on hand taxonomy. In addition, there is enough range of mobility for the TN hand to perform column chords due to the ability to abduct fingers.Electric prosthetic hands have problems of heavyweight, unsuitability for working near water, and driving noise. Although body-powered prosthetic hands solve these problems, they have operability and wearability problems related to a cable control system. In this paper, we report a prosthetic gripper with three opposing fingers driven by a hydraulic actuator without electrical components. The three fingers are controlled simultaneously by pushing the lever of an operating interface mounted on the user's upper arm on the affected side. The hydraulic actuator enables users to open the fingers with a force of 16.6 N. The operating interface can be worn without a harness. The total weight is 316 g. Grasping tests of abstract and daily objects in which two amputees participated demonstrated that two amputees were able to grasp various objects. Quietness was also confirmed by them.Thumb movement is very important for object gripping. However, when a cerebrovascular disorder or spinal cord injury causes hand paralysis, which impairs the motor function of the fingers, it becomes impossible to flex and extend the fingers and to move the thumb to the opposition position; this makes it difficult to grip objects in daily life. Several assistive devices have been developed for people with hand paralysis. However, they only assist flexion/extension of the thumb, narrow the type of grip by fixing the thumb position, or have large sizes and weights due to using links and frames to assist thumb adduction and opposition. They are not effective for daily use. Thumb motion assistance that does not hinder the degree of freedom of the thumb is important for gripping objects in everyday life. In this study, we developed a wearable ring and a fingertip-cap that assist two-degree-of-freedom thumb motion by means of a tendon-drive based on the hand's anatomy; the feasibility of the device is confirmed through basic experiments, in which the device was evaluated by a hand in a weakened state. It was confirmed that opposing movement and flexion/extension motion of the thumb were possible. In addition, we confirmed that it was possible to grip thin objects by using only thumb motion assistance. In conclusion, we developed a tendon-driven thumb motion assistive device using a ring-shaped component and confirmed the feasibility of this system to support the opposition/reposition and flexion/extension motions of the thumb.This paper presents the design of a motor-augmented wrist-driven orthosis (MWDO) for improved grasp articulation for people with C6-C7 spinal cord injuries. Based on the traditional passive, wrist-driven orthotic (WDO) mechanism, the MWDO allows for both body-powered and motorized actuation of the grasping output thus enabling more flexible and dexterous operation. Here, the associated control scheme enables active decoupling of wrist and finger articulation, which can be useful during certain phases of manipulation tasks. An additional modification to the traditional WDO is the integration of a magnetic latch at the Distal Interphalangeal (DIP) joint allowing for improved pinching. These abilities are demonstrated with common activities of daily living (ADL).To increase the acceptability of exoskeletons, there is growing attention toward finding an alternative soft actuator that can safely perform at close vicinity of the human body. In this study, we investigated the capability of the dielectric elastomer actuators (DEAs), for muscle-like actuation of rehabilitation robots. First, an artificial skeletal muscle was configured using commercially available stacked DEAs arranged in a 3x4 array of three parallel fibers consisting of four DEAs connected in series. The shortening and force generation capabilities of this artificial muscle were then measured. An alternate 3x5 version of this muscle was mounted on the forearm of an upper extremity phantom model to actuate its elbow joint. Resveratrol The actuation capability of this muscle was then tested under various tensile loads, 1 N to 4 N, placed at the center of mass of the forearm+hand of the phantom model. The active range of motion and angular velocity of the phantom model's tip of the hand were measured using a motion capture system. The 3×4 artificial muscle produced 30.47 N of force and 5.3 mm of maximum shortening. The 3x5 artificial muscle was capable of actuating the elbow flexion 19.5º with 16.2 º/s angular velocity in the sagittal plane, under a 1 N tensile load. The active range of motion was substantially reduced as the tensile loads increased, which limits the capability of these muscles in the current upper extremity exoskeleton design.Wearable, mechanically passive (i.e. spring-powered) exoskeletons may be more practical and affordable than active, motorized exoskeletons for providing continuous, home-based, antigravity movement assistance for people with shoulder disability. However, the biomechanical moment due to gravity is a nonlinear function of shoulder elevation angle and, thus, challenging to counteract proportionally across the shoulder elevation range of motion with a spring alone. We designed, fabricated, and tested an integrated spring-cam-wheel system that can generate a nonlinear moment to proportionally compensate for the expected antigravity moment at the shoulder. We then incorporated the proposed system in a benchtop model and a novel wearable passive cable-driven exoskeleton that was intended to counteract half of the gravitational moment during shoulder elevation movements. The rotational moment measured from the benchtop model closely matched the theoretical moment during simulated positive shoulder elevation. However, a larger moment (up to 12.5% larger) was required during simulated negative shoulder elevation to stretch the spring to its initial length due to spring hysteresis and friction losses. The wearable exoskeleton prototype was qualitatively tested for assisting shoulder elevation movements; we identified several aspects of the prototype design that need to be improved before further testing on human participants. In future studies, we will quantitatively evaluate human kinematics and neuromuscular coordination with the exoskeleton to determine its suitability for assisting patients with shoulder disability.Individuals with neurological impairment, particularly those with cervical level spinal cord injuries (SCI), often have difficulty with daily tasks due to triceps weakness or total loss of function. More demanding tasks, such as sit-skiing, may be rendered impossible due to their extreme strength demands. Design of exoskeletons that address this issue by providing supplemental strength in arm extension is an active field of research but commercial devices are not yet available for use. Most current designs employ electric motors that necessitate the addition of bulky power sources and extraneous wiring, rendering the devices impractical in daily life. The possibility of powering an upper extremity exoskeleton passively has been explored, but to date, none have delivered sufficient function or strength to provide useful assistance for sit-skiing. We seek to rectify this with the design of a passively actuated exoskeletal arm brace capable of operating in two, adjustable-strength modes one for low level gravity compensation to aid in active range of motion, and the other for more stringent weight bearing activities. The mechanism developed through this paper allows for an affordable, lightweight, modular device that can be adjusted and customized for the needs of each individual patient.Work-related musculoskeletal disorders (MSDs) are a major concern in industries and working environments. They cause not only suffering to the employee and decrease in performance, but also high economic losses to the companies and the society. Workers from assembly lines and machine operators are one of the most frequently affected working population. Moreover, one of the main types of MSDs in occupational environments are shoulder injuries. Exoskeletons have been applied and tested in rehabilitation and they are gaining ground in occupational environments as assistive devices to augment human force and minimize loads on muscles and joints. However, more evidence about the effects of several exoskeletons models in assisting different tasks is needed. We measured shoulder muscles activity (AD - anterior deltoid and MD - medial deltoid) of seven automotive workers using the SuitX® upper limb exoskeleton while performing different screwing tasks, at different shoulder levels while handling different tools. We found significant muscle activity reduction for 2 of the 4 proposed tasks, suggesting a task-specificity effectiveness.
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