Notes

How does plot medicine affect healthcare trainees' understanding regarding professionalism and reliability? Any qualitative study.
22 [95%CI 0.05-0.97]; P=.04) and discoid CLE lesions (odds ratio, 0.14 [95%CI, 0.04-0.48]; P=.004) were associated with a lower risk of long-term remission.

Partial retrospective data collection and tertiary center population.

Long-term remission is rare in CLE and negatively associated with active smoking and discoid CLE.
Long-term remission is rare in CLE and negatively associated with active smoking and discoid CLE.
Acute kidney injury (AKI) causes biochemical changes in the brain in animal models and is associated with adverse neurological complications in hospitalized patients. This study tested the association between AKI and incident dementia in a community-based cohort.

Prospective cohort study.

Adult participants in the Atherosclerosis Risk in Communities (ARIC) study who experienced hospitalized AKI compared with participants hospitalized for other reasons (primary analysis, mean follow-up period 4.3 years) or participants without hospitalized AKI (secondary analysis).

Incident AKI, defined by ICD codes from hospital records.

Incident dementia, diagnosed based on a combination of neurocognitive testing, informant interviews, ICD codes, and death certificates.

In the primary analysis, we estimated the propensity for hospitalized AKI and matched these participants with those hospitalized for another reason to examine the association of AKI with subsequent onset of dementia (N= 1,708). In the secondary anObservational study, with AKI identified through diagnosis codes.

Participants who experienced a hospitalization for AKI were at increased risk of dementia.
Participants who experienced a hospitalization for AKI were at increased risk of dementia.Knowing the distribution of venomous snakes of medical importance is essential to identify areas at risk for snakebites. Thus, we used an integrative approach based on the application of geographic distribution data of venomous snakes, species distribution modeling (SDM), spatial organization of snakebites, and information on human population density for mapping the potential distribution of snakes and identifying areas at risk of snakebites in the state of Maranhão (mid-northern Brazil). From a compiled database of venomous snake records deposited in biological collections and the literature, we predict the potential distribution of venomous snakes in Maranhão, a state whose diversity and geographic distribution of venomous snake species are poorly known. With this, we constructed potential distribution maps for each venomous snake species with at least one occurrence record within state boundaries, as well as generalized maps by family (Viperidae and Elapidae) and the total number of venomous snakes in Maraioneer in using species distribution modeling in mid-northern Brazil to address the scarcity of data on snakebite-causing species, directly contributing to the theme of neglected tropical diseases of the World Health Organization.Ricin toxin (RT) is one of the most lethal type II ribosome-inactivating proteins (RIP), and is classified as a potential bioterror agent due to its severe cytotoxicity and high availability. The toxicity of RT is dependent on both dose and route of exposure. Increasing evidence demonstrates that sub-lethal RT induces acute inflammation and increases the release of pro-inflammatory cytokines. However, current studies on mechanism of RT-induced inflammation are limited. In this study, to evaluate the relationship between miRNAs and RT-induced inflammation, RNA sequencing (RNA-Seq) was used to analyze the expression of miRNAs and mRNAs in RT-treated RAW264.7 macrophage cells. A total of 14 significantly differently expressed (DE) miRNAs and 323 miRNA-mRNA interaction pairs were predicted by bioinformatics analysis. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed that majority of those interaction pairs were involved in PI3K/Akt pathway. In addition, overexpression of miR-221-5p promoted the inflammatory response by inhibiting the mRNA expression of COL4a5. This work contributes to our understanding of RT-induced inflammation and demonstrates the potential role of miRNAs in innate immunity, which may be regarded as potential targets in developing therapies for RT poisoning.Despite the dynamic development of cancer research, annually millions of people die of cancer. The human immune system is the major 'guard' against tumor development. Unfortunately, cancer cells have the ability to evade the immune system and continue to grow. The proper understanding of the intricate immune response in tumorigenesis remains the holy grail of cancer immunology and designing effective immunotherapy. To decode the immune responses in cancer, in recent years, proteomics studies have received considerable attention. Proteomics studies focus on the detection and quantification of proteins, which are the effectors of biological functions, and as such, are proven to reflect the cell state more accurately, in comparison to genomic or transcriptomic studies. In this review, we discuss the proteomics studies applied to characterize the immune responses in cancer and tumor immune microenvironment heterogeneity. Further, we describe emerging single-cell proteomics approaches that have the potential to be applied in cancer immunity studies.Triggering receptor expressed on myeloid cells-1 (TREM-1) is a transmembrane protein expressed on endothelial cells, white blood cells, smooth muscle cells and platelets. TREM-1 plays an important role in innate immunity. TREM-1 activation pathways are implicated both in sepsis and in non-infectious inflammatory conditions, including atherosclerosis. TREM-1 enhances the subendothelial lipid accumulation and expression of pro-inflammatory cytokines and matrix-degrading enzymes, thereby promoting inflammation and plaque destabilization. TREM-1 inhibitors attenuate the inflammatory process in the atherosclerotic plaque, leading to plaque stabilization. This review focuses on the role of TREM-1 in the pathophysiology of atherosclerosis and the effects of TREM-1 inhibition in the natural history of the disease.Concurrent use of a diuretic, a renin-angiotensin system (RAS) inhibitor, and a non-steroidal anti-inflammatory drug (NSAID) significantly increases the risk of acute kidney injury (AKI). This phenomenon is known as "triple whammy". Diuretics and RAS inhibitors, such as an angiotensin converting enzyme (ACE) inhibitor or angiotensin receptor blocker, are often prescribed in tandem for the treatment of hypertension, whereas some NSAIDs, such as ibuprofen, are available over the counter. As such, concurrent treatment with all three drugs is common. The goals of this study are to better understand the mechanisms underlying the development of triple whammy AKI and to identify physiological factors that may increase an individual's susceptibility. To accomplish these goals, we utilize sex-specific computational models of long-term blood pressure regulation. These models include variables describing the heart and circulation, kidney function, sodium and water reabsorption in the nephron and the RAS and are parameterized separately for men and women. Hypertension is modeled as overactive renal sympathetic nervous activity. Model simulations suggest that low water intake, the myogenic response, and drug sensitivity may predispose patients with hypertension to develop triple whammy-induced AKI. Triple treatment involving an ACE inhibitor, furosemide, and NSAID results in blood pressure levels similar to double treatment with ACEI and furosemide. Additionally, the male and female hypertensive models act similarly in most situations, except for the ACE inhibitor and NSAID double treatment.Both cancer and diabetes mellitus are serious health issues, accounting more than 11 million deaths worldwide annually. Targeted use of plant-mediated nanoparticles (NPs) in treatment of ailments has outstanding results due to their salient properties. The current study was designed to investigate the safe production of silver nanoparticles (AgNPs) from Acacia nilotica. Different concentrations of AgNO3 were tested to optimize the protocol for the synthesis of AgNPs from the bark extract. It was demonstrated that 0.1 M and 3 mM were found to be the optimum concentrations for the synthesis of AgNPs. Standard characterization techniques such as UV-vis spectrophotometry, SEM, SEM-EDX micrograph, spot analysis, elemental mapping and XRD were used for the conformation of biosynthesis of AgNPs. Absorption spectrum of plant-mediated AgNPs under UV-vis spectrophotometer showed a strong peak at 380 nm and 420 nm for AgNPs synthesized at 0.1 M and 3 mM concentration of salt. The SEM results showed that AgNPs were present in variable shapes within average particle size ranging from (20-50 nm). Menadione Anticancer, antidiabetic and antioxidant potential of green AgNPs was investigated and they showed promising results as compared to the positive and negative controls. Hence, AgNPs were found potent therapeutic agent against the human liver cancer cell lines (HepG2), strong inhibitor for α-glucosidase enzyme activity and scavenging agent against free radicals that cause oxidative stress. Further studies are however needed to confirm the molecular mechanism and biochemical reactions responsible for the anticancer and antidiabetic activities of the particles.Mitigation of ambient ozone (O3) pollution is a great challenge because it depends heavily on the background O3 which has been poorly evaluated in many regions, including in China. By establishing the relationship between O3 and air temperature near the surface, the mean background O3 mixing ratios in the clean and polluted seasons were determined to be 35-40 and 50-55 ppbv in China during 2013-2019, respectively. Simulations using the chemical transport model (i.e., the Weather Research and Forecasting coupled with Chemistry model, WRF/Chem) suggested that biogenic volatile organic compounds (VOC) emissions were the primary contributor to the increase in the background O3 in the polluted season (BOP) compared to the background O3 in the clean season (BOC), ranging from 8 ppbv to 16 ppbv. More importantly, the BOP continuously increased at a rate of 0.6-8.0 ppbv yr-1 during 2013-2019, while the non-BOP stopped increasing after 2017. Consequently, an additional 2%-16% reduction in anthropogenic VOC emissions is required to reverse the current O3 back to that measured in the period from 2013 to 2017. The results of this study emphasize the importance of the relative contribution of the background O3 to the observed total O3 concentration in the design of anthropogenic precursor emission control strategies for the attainment of O3 standards.Tropospheric ozone threatens crop production in many parts of the world, especially in highly populated countries in economic transition. Crop models suggest substantial global yield losses for wheat, but typically such models fail to address differences in ozone responses between tolerant and sensitive genotypes. Therefore, the purpose of this study was to identify physiological traits contributing to yield losses or yield stability under ozone stress in 18 contrasting wheat cultivars that had been pre-selected from a larger wheat population with known ozone tolerance. Plants were exposed to season-long ozone fumigation in open-top chambers at an average ozone concentration of 70 ppb with three additional acute ozone episodes of around 150 ppb. Compared to control conditions, average yield loss was 18.7 percent, but large genotypic variation was observed ranging from 2.7 to 44.6 percent. Foliar chlorophyll content represented by normalized difference vegetation index and net CO2 assimilation rate of young leaves during grain filling were the physiological traits most strongly correlated with grain yield losses or stability.
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