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A novel pathogenic splice site deviation in STK11 gene ends in Peutz-Jeghers symptoms.
We study the stabilisation of clusters and lattices of cuboidal particles with long-ranged magnetic dipolar and short-ranged surface interactions. Two realistic systems were considered one with magnetisation oriented in the [001] crystallographic direction and the other with magnetisation along the [111] direction. We have studied magnetic nanocube clusters first in the limit of T = 0 K intending to elucidate the structural genesis of low energy configurations and then analysed finite-temperature behaviour of the same systems in simulations. Our results demonstrate that dipolar coupling can stabilise nanoparticle assemblies with cubic, planar, and linear arrangements seen previously in experiments. While attractive surface energy supports the formation of super-cubes, repulsion results in the elongated structures in the form of rods and chains. We observe the stabilisation of the ferromagnetic planar arrangements of the cubes standing on their corners and in contact over edges. We illustrate that minimal energy structures depend only on the size of the assembly and balance of surface repulsion and magnetic dipolar coupling. The presented results are scalable to different particle sizes and material parameters.A large kinetic isotope effect (KIE, kH/kD) of 12.8 was observed for the hydrogen-transfer reaction from ascorbic acid to 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO˙) in a phosphate buffer solution (0.05 M, pH/pD 7.0) at 298 K. The isotopic difference in the activation energies (6.8 kJ mol-1) determined from the temperature dependence of the KIE suggests that quantum mechanical tunneling may partly play a role in the reaction, although the isotopic ratio of the Arrhenius prefactor (AH/AD = 0.86) is within the semiclassical limits.It is vital to tailor the surface structure and composition of nanocatalysts, which greatly affect the catalytic activity through the exposure of specific atom coordination environment. To date, less progress has been made in tuning the interface structures of pyrite for promoting the catalytic activity towards overall water splitting. Herein, we developed a facile one-spot strategy to make carbon-layer-coated CoS2-FeS2 heterojunction nanosheets. The carbon layer and interface structures between Co-S and Fe-S were characterized via high resolution transmission electron microscopy. It exhibited a high OER activity with 1.47 V at 10 mA cm-2, which was superior to that of the commercial RuO2. Meanwhile, the carbon-layer-coated CoS2-FeS2 heterojunction nanosheets with the overpotential of 210 mV at 10 mA cm-2 was more active than FeS2 nanosheets with 240 mV in the hydrogen evolution reaction. Notably, it enhanced the catalytic activity towards the overall water splitting with the voltage of 1.66 V at 10 mA cm-2 using a two-electrode system. The remarkable long-term stability was verified by a slight change in the current density of 6 mA cm-2 for 26 h. The prominent catalytic activity could be related to the exposure of the carbon layer and interface structures. This work demonstrates that engineering the interface structure is essential for boosting the overall water splitting activity.2D materials are gaining more and more interest owing to their promising applications in future electronic industry. Here, two new quasi-2D metal cyanurates, K4Cu3(C3N3O3)2X (X = Cl, Br), were grown and characterized for the first time. They belong to the trigonal P3[combining macron]m1 space group and feature an infinite layer, constructed by p-p conjugation in the (C3N3O3) planar six-membered-rings and d-p conjugation in the N-Cu-N linear chains. Moreover, they are indirect semiconductors with suitable bandgaps of 3.5 eV, locating between g-C3N4 and h-BN. The electronic states and anisotropic optical responses were also studied through theoretical calculations.Phage-based biosensors have shown significant promise in meeting the present needs of the food and agricultural industries due to a combination of sufficient portability, speed, ease of use, sensitivity, and low production cost. Although current phage-based methods do not meet the bacteria detection limit imposed by the EPA, FDA, and USDA, a better understanding of phage genetics can significantly increase their sensitivity as biosensors. In the current study, the signal sensitivity of a T4 phage-based detection system was improved via transcriptional upregulation of the reporter enzyme Nanoluc luciferase (Nluc). An efficient platform to evaluate the promoter activity of reporter T4 phages was developed. The ability to upregulate Nluc within T4 phages was evaluated using 15 native T4 promoters. Data indicates a six-fold increase in reporter enzyme signal from integration of the selected promoters. Collectively, this work demonstrates that fine tuning the expression of reporter enzymes such as Nluc through optimization of transcription can significantly reduce the limits of detection.Correction for 'Structural reconstruction a milestone in the hydrothermal synthesis of highly active Sn-Beta zeolites' by Zhiguo Zhu et al., Chem. Commun., 2017, 53, 12516-12519, DOI 10.1039/C7CC06778J.Spatially indirect excitons are important not only for the exploration of intriguing many-body effects but also for the development of applications such as solar cells with high efficiency. This type of exciton usually exists in heterostructures. Using the generalized Bloch theorem coupled with the density-functional tight-binding method, we reveal that spatially indirect excitons may emerge in single crystalline ZnO nanowires under bending. The underlying mechanism is attributed to the formation of an effective type-II band alignment due to the strain-gradient of the bent nanowires. Our finding paves a new route to realize spatially indirect excitons by strain engineering.Oral lichen planus (OLP) is a chronic inflammatory and immune-mediated disease affecting the oral mucosa. OLP presents with asymptomatic, lacelike white stripes and/or symptomatic red, ulcerated mucous membranes. selleck chemical Eating, drinking and oral hygiene procedures may be painful resulting in reduced quality of life (QOL). The histopathological picture is a zone of cellular infiltrate, mainly CD8+ cells, in the superficial layer of the connective tissue and signs of liquefaction degeneration of the basal membrane. Conventional treatment is corticosteroids. Local and systemic side effects are common, and patients may develop drug resistance. The intention with this article is to demonstrate the heterogeneity in photodynamic therapy (PDT) of OLP. A search in PubMed, Embase (Ovid) and Medline (Ovid) identified seventeen clinical studies investigating PDT of OLP. Only five were randomised controlled studies and the study groups varied from 5 to 50 patients. Five different photosensitisers or precursors were tested. Both broadband spectrum lamps, lasers and light-emitting-diodes (LEDs), with wavelengths from 420 nm to 682 nm, were used.
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