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Dispersive and filter damage efficiency of calcium supplement carbonate nanoparticles throughout normal water for drilling fluid programs.
A combination of cocktail chemotherapy (CCT), photothermal therapy (PTT) and inhibition of angiogenesis was investigated as an effective approach to combat major challenges of multidrug resistance and non-targeted drug delivery encountered in conventional cancer therapy. An injectable nanocarrier was developed through functionalization of carbon nanotubes (CNTs) with rationally modified carbohydrate (β-Cyclodextrin-CD) derived pH and thermo responsive polymer. Embedding CNT to CD polymer offers a nanocarrier which effectively demonstrated CCT, high NIR triggered photothermal efficiency, anti-angiogenic potential for selective tumor homing as well as enhanced multi-drug resistance (MDR) reversal with minimal toxic effects on normal cells. The simultaneously loading with curcumin and doxorubicin hydrochloride exhibited synergistic effect for triggering antitumor effect in vitro and demonstrated down regulation of growth factors associated with angiogenesis ex-ovo. In-vivo studies ascertained that the nanocarrier synthesized with the rational for MDR reversal can lead to enhanced cancer cell death via multiple approaches.Auricularia auricula is a well-known traditional edible fungus with high nutritional and pharmacological values. Polysaccharides are identified as one of the pivotal bioactive constituents of natural extracts of A. auricula. Accumulating evidence has revealed that polysaccharides from A. BMS202 cost auricula (AAPs) exhibit diverse biological functions. Hence, a systematic review of research advances and future prospects of AAPs is very necessary for facilitating their better understanding. In this review, we have summarized current knowledge about extraction and purification methods, structural features, biological activities and potential molecular mechanisms of AAPs. Besides, the proposed structure-activity relationships of AAPs have also been highlighted and discussed. This review may provide some valuable insights for further researches regarding AAPs.To enhance the drug delivery efficiency of hyaluronic acid (HA), we designed and prepared glycodendron and pyropheophorbide-a (Ppa)-functionalized HA (HA-Ppa-Dendron) as a nanosystem for cancer photodynamic therapy. Linear Ppa-modified HA (HA-Ppa) was also prepared as a control. Cellular uptake of both polymers by MDA-MB-231 cells led to mitochondrial dysfunction and generation of reactive oxygen species under the irradiation of a laser. Compared to the linear polymer, HA-Ppa-Dendron had higher molecular weight, a more compact nanoscale particle size, and a dendritic structure, resulting in a much longer blood circulation time and higher tumor accumulation. HA-Ppa-Dendron outperformed HA-Ppa in inhibiting cell growth, with 60 % of tumors was eradicated under laser irradiation. Tumor growth inhibition (TGI) up to 99.2 % was achieved from HA-Ppa-Dendron, which was much higher than that of HA-Ppa (50.6 %). Therefore, glycodendron-functionalized HAs by integration of HA and dendritic polymers may act as efficient anti-cancer nanomedicine.Iron/silica core-shell microparticles (IMPs) were functionalized by different functional groups including amine, glycidoxy, phenyl, and thiocyanate. Many of the IMPs modifications are reported for the first time. The resulting surface chemistry turned out to affect the properties of magnetic alginate hydrogels fabricated from sodium alginate and dispersed IMPs. Differences in magnetorheological properties of the obtained magnetic hydrogels can be at least partially attributed to the interactions between alginate and surface functionalities of IMPs. Density Functional Theory (DFT) calculations were carried out to get detailed insight into those interactions in order to link them with the observed macroscopic properties of the obtained hydrogels. For example, amine groups on the IMPs surface resulted in well-formed hydrogels while the presence of thiocyanate or phenyl groups - in poorly formed ones. This observation can be used for tuning the properties of various carbohydrate-based hydrogels.In this work, we propose a novel approach to produce a high-strength epoxy nanocomposite using ionic liquids facilitated dispersion of chitin nanowhiskers (CNWs). Samples with 0-3 wt% CNWs and 1 wt% of [Emim][OAc] were fabricated by mixing, casting, and curing. The morphological observations of the ethanol/ionic liquid suspensions by TEM indicated that [Emim][OAc] helped in dispersing the CNWs. The tensile, impact, dynamical mechanical properties, and thermal stability of the composites were further evaluated to access the reinforcing effect of CNWs. Increase of 35 % tensile strength, 175 % toughness and 90 % impact strength were observed upon addition of 2 wt% of CNWs. Thermal stability of the epoxy was not affected by the addition of CNWs. The SEM observations of the composites evidenced that the fracture mechanisms had changed upon CNWs addition. This work shows the advantage of the novel approach using ionic liquids as nanofiller dispersant in fabricating CNWs nanocomposites.Tough and conductive hydrogels are promising materials for various applications. However, it remains a great challenge to develop an integrated hydrogel combining outstanding mechanical, conductive, and self-healing performances. Herein, we prepared a conductive, self-healing, and tough hydrogel by constructing synergistic multiple interaction among montmorillonite (MMT), Poly (acrylamide-co-acrylonitrile) (P(AAm-co-AN)), xanthan gum (XG) and ferric ion (Fe3+). The obtained xanthan gum/montmorillonite/Poly (acrylamide-co-acrylonitrile) (XG/MMT/PAAm) hydrogels showed high strain stress (0.48 MPa) and compressive stress (5.9 MPa) as well as good shape recovery after multiple loading-unloading cycle tests. Moreover, the XG/MMT/PAAm hydrogels have distinctive features such as remarkable resistance to fatigue and harsh environments, insensitivity to notch, conductive, biocompatible, pH-dependent swelling behaviors and self-healing. Therefore, the as-fabricated hydrogel delivers a new prospect for its applications in various fields, such as flexible conductive device and tissue engineering.Two modified citrus pectins, MCP4 and MCP10, were prepared by UV/H2O2 treatment at pH 4 and pH 10, respectively, and their structures were characterized. MCP10 had a rhamnogalacturonan-I (RG-I) enriched backbone with a high degree of branching (DB ∼61 %) and a low methoxylation degree (24 %). MCP4 had a homogalacturonan enriched backbone with a high degree (46 %) of methoxylation and a low DB (∼41 %) of RG-I branches. MCP10 exhibited a higher anti-inflammatory activity than MCP4 in suppressing the NF-κB expression and the production of pro-inflammatory factors TNF-α and IL-1β of THP-1 cells stimulated by lipopolysaccharide. MCP10 also showed a stronger inhibitory effect on Caco-2 cell proliferation. The stronger bioactivities of MCP10 may be attributable to the abundant branches and the proper length of terminal galactan residues attached to the RG-I domain.
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