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Wheat or grain yellow mosaic improves microbe deterministic processes in the plant-soil program.
© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.This paper addresses the question of the contribution of azimuthally localized flow channels and magnetic field dipolarizations embedded in them in the global dipolarization of the inner magnetosphere during substorms. We employ the high-resolution Lyon-Fedder-Mobarry global magnetosphere magnetohydrodynamic model and simulate an isolated substorm event, which was observed by the geostationary satellites and by the Magnetospheric Multiscale spacecraft. The results of our simulations reveal that plasma sheet flow channels (bursty bulk flows, BBFs) and elementary dipolarizations (dipolarization fronts, DFs) occur in the growth phase of the substorm but are rare and do not penetrate to the geosynchronous orbit. The substorm onset is characterized by an abrupt increase in the occurrence and intensity of BBFs/DFs, which penetrate well earthward of the geosynchronous orbit during the expansion phase. These azimuthally localized structures are solely responsible for the global (in terms of the magnetic local time) dipolarization of the inner magnetosphere toward the end of the substorm expansion. Comparison with the geostationary satellites and Magnetospheric Multiscale data shows that the properties of the BBFs/DFs in the simulation are similar to those observed, which gives credence to the above results. Additionally, the simulation reveals many previously observed signatures of BBFs and DFs, including overshoots and oscillations around their equilibrium position, strong rebounds and vortical tailward flows, and the corresponding plasma sheet expansion and thinning. ©2019. The Authors.Introduction Breast cancer is the most common cancer diagnosis in the UK. Recently, there has been a reduction in breast cancer-specific mortality and recurrence attributed, in part, to the delivery of adjuvant chemotherapy. The National Institute for Health and Care Excellence (NICE) recommends the use of genetic profiling with Oncotype DX (ODX) to guide decisions to offer adjuvant chemotherapy after surgery in intermediate-risk early breast cancer patients. This study aimed to evaluate the utility of ODX testing in routine clinical practice in a National Health Service (NHS) hospital. Methods Consecutive early breast cancer patients, identified through the multidisciplinary team (MDT) records, treated in our institution over 12 months (October 2017-September 2018) were included. PREDICT and Nottingham prognostic index (NPI) scores (from online clinicopathological recurrence risk tools) were calculated for each patient, and ODX data obtained through Genomic Health, Inc. (Redwood City, California). Patients he ODX group (39.9% vs 6.9%, P less then 0.001). However, for the PREDICT-calculated intermediate-risk patients, ODX testing resulted in a lower proportion of patients being offered chemotherapy compared to the intermediate-risk patients who were not genetically profiled (54.5% vs 83.3%, P=0.3547), although this result was not statistically significant. Conclusions Patients selected for ODX testing were younger, with significantly higher-grade and larger-sized tumours compared to patients not selected for genetic profiling. ODX testing significantly impacted the delivery of chemotherapy, as the recurrence score generated through ODX testing guided the final decision. Copyright © 2020, Rizki et al.Aim To quantify the global incidence and mortality of adverse effects of medical treatment (AEMT) and forecast the possible emerging trends of AEMT. Materials and methods We analyzed the latest data from the Global Burden of Disease (GBD) 2017 study. We describe the burden of AEMT based on age- and region-specific incidence and mortality rates between 1990 and 2017. Additionally, we evaluated the change of burden due to AEMT by different periods between 1990 and 2017, and compared the age-standardized incidence and mortality rates among different World Health Organization (WHO) regions. Results Globally, AEMT incidence rates varied across WHO regions and countries. The estimated age-standardized average incidence rates of AEMT were 309 [95% uncertainty interval (UI), 270 to 351], 340 (298 to 384), 401 (348 to 458), and 439 (376 to 505) per 100,000 population across the world in 1990, 2000, 2010, and 2017, respectively, showing an increasing trend in the new occurrence of adverse events. The incidence rate amof 65 years and above. The global mortality rate due to AEMT is expected to be 1.55 (1.48 to 1.61) in 2020, 1.37 (0.88 to 1.86 ) in 2030 and 1.2 deaths per 100,000 (0.08 to 2.32) by 2040. Conclusion Using the GBD 2017 study data, we found an increase in the incidence of AEMT, and an overall decrease in the mortality rate between 1990 and 2017, with varying estimates between different countries and regions, gender and age groups. The forecast analysis displayed the same trends - an increase in AEMT incidence and a decline in mortality between 2020 and 2040. The high burden of AEMT warrants the implementation of robust policies in the healthcare system including appropriate patient safety training for the healthcare professionals, and safe culture of feedback with the implementation of electronic medical records to achieve WHO patient safety strategy goals. Copyright © 2020, Nauman et al.Background Beta-lactamase enzymes-producing Enterobacteriaceae have emerged in many hospital settings resulting in poor treatment outcomes. We aimed to determine resistant patterns of Beta-lactamase enzymes among Enterobacteriaceae collected from referral hospitals in Khartoum state, Sudan. Methods A total of 168 Enterobacteriaceae recovered from clinical samples of patients during May 2014 to February 2015. Identification and susceptibility testing of the isolates were performed as per standard methods. Double-disk synergy test was applied to determine the presence of extended-spectrum β-lactamase (ESBL) production. AmpC beta-lactamases and carbapenemase were screened using AmpC disk test and the modified Hodge test, respectively. Results ESBL-producing Enterobacteriaceae represented 45.2%, with a higher rate among K. pneumoniae. AmpC beta-lactamase detected as 49.3%, with peak levels among Acinetobacter baumannii (A. read more baumannii) (83.3%) and Enterobacter cloacae (75%). Carbapenemase production was found among 74.
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