Notes

Therapy associated with eyewitness statement inside Belgium inside the Twentieth century.
The extracts had moderate in vitro antioxidant activity but the in vivo antioxidant and anti-inflammatory effects were significant and associated with myocardial and renal dysfunction improvement. The results were attributed to the content of polyphenols in the extracts, for which reason C. intybus may be considered an important raw material for pharmaceuticals formulations recommended in the prevention or treatment of heart or kidney diseases.
The combination of the unique properties of cancer cells makes it possible to find specific ligands that interact directly with the tumor, and to conduct targeted tumor therapy. Phage display is one of the most common methods for searching for specific ligands. Bacteriophages display peptides, and the peptides themselves can be used as targeting molecules for the delivery of diagnostic and therapeutic agents. Phage display can be performed both in vitro and in vivo. Moreover, it is possible to carry out the phage display on cells pre-enriched for a certain tumor marker, for example, CD44 and CD133.

For this work we used several methods, such as phage display, sequencing, cell sorting, immunocytochemistry, phage titration.

We performed phage display using different screening systems (in vitro and in vivo), different phage libraries (Ph.D-7, Ph.D-12, Ph.D-C7C) on CD44+/CD133+ and without enrichment U-87 MG cells. The binding efficiency of bacteriophages displayed tumor-targeting peptides on U-87 MG cells was compared in vitro. We also conducted a comparative analysis in vivo of the specificity of the accumulation of selected bacteriophages in the tumor and in the control organs (liver, brain, kidney and lungs).

The screening in vivo of linear phage peptide libraries for glioblastoma was the most effective strategy for obtaining tumor-targeting peptides providing targeted delivery of diagnostic and therapeutic agents to glioblastoma.
The screening in vivo of linear phage peptide libraries for glioblastoma was the most effective strategy for obtaining tumor-targeting peptides providing targeted delivery of diagnostic and therapeutic agents to glioblastoma.Ben-Or and Linial, in a seminal work, introduced the full information model to study collective coin-tossing protocols. Collective coin-tossing is an elegant functionality providing uncluttered access to the primary bottlenecks to achieve security in a specific adversarial model. Eribulin molecular weight Additionally, the research outcomes for this versatile functionality has direct consequences on diverse topics in mathematics and computer science. This survey summarizes the current state-of-the-art of coin-tossing protocols in the full information model and recent advances in this field. In particular, it elaborates on a new proof technique that identifies the minimum insecurity incurred by any coin-tossing protocol and, simultaneously, constructs the coin-tossing protocol achieving that insecurity bound. The combinatorial perspective into this new proof-technique yields new coin-tossing protocols that are more secure than well-known existing coin-tossing protocols, leading to new isoperimetric inequalities over product spaces. Furthermore, this proof-technique's algebraic reimagination resolves several long-standing fundamental hardness-of-computation problems in cryptography. This survey presents one representative application of each of these two perspectives.This study aimed to determine the influence of the volume fraction of steel fibers on the fracture parameters of concrete. Fifty notched steel-fiber-reinforced concrete (SFRC) beams and ordinary concrete beams with 100 mm × 100 mm × 515 mm were cast and tested via a three-point bending test. Among them, the type of steel fiber was the milling type (MF), and the volume fraction of steel fiber added was 0%, 0.5%, 1%, 1.5% and 2%, respectively. The effects of the steel fiber volume fraction (VF) on the critical stress intensity factor (KIC), fracture energy (GF), the deflection at failure(δ0), the critical crack mouth opening displacement (CMODC) and the critical crack tip opening displacement (CTODC) were studied. Through the analysis of test phenomena and test data such as the load-deflection (P-δ) curve, load-crack mouth opening displacement (P-CMOD) curve and load-crack tip opening displacement (P-CTOD) curve, the following conclusions are drawn with the increase of the steel fiber volume fraction, some fracture parameters increase gradually and maintain a certain linear growth. The gain ratio of the fracture parameters increases significantly, and the gain effect is obvious. Through this law of growth, the experimental statistical formulas of fracture energy and the critical stress intensity factor are summarized.Power-line communication (PLC) networks have been increasingly used for constructing industrial IoT (internet of things) and home networking systems due to their low-cost installation and broad coverage feature. To guarantee the transmission reliability, ARQ (automatic repeat request) scheme is introduced into the link layer of reliable PLC networks, which allows the retransmission of a data frame several times so that it has a higher probability to be correctly received. However, current studies of performance analysis for PLC MAC (medium access control) protocol (i.e., IEEE 1901) do not take into account of the impact of ARQ scheme. To resolve this problem, we propose an analytical model to investigate the MAC performance of IEEE 1901 protocol for reliable PLC networks with ARQ scheme. In the modeling process, we first establish a PLC channel model to reflect the impacts of PLC channel types (containing Rayleigh fading and Log-normal fading), additive non-Gaussian noise feature and ARQ scheme on data transmission at link layer. Next, we employ Renewal theory and Queueing dynamics to capture the transmission attempt behavior of executing IEEE 1901 protocol in the unsaturated environment with finite transit buffer size. On the basis of combining these two models, we derive the closed-form expressions of 1901 MAC metrics considering the influence of the ARQ scheme. Furthermore, we prove that the proposed analytical model has the convergence property. Finally, we evaluate the MAC performance of 1901 protocol for reliable PLC networks with ARQ scheme and verify the proposed analytical model.Metabolic enzyme and/or transporter-mediated pharmacokinetic (PK) changes in a drug caused by concomitant herbal products have been a primary issue of herb and drug interactions (HDIs), because PK changes of a drug may result in the alternation of efficacy and toxicity. Studies on HDIs have been carried out by predictive in vitro and in vivo preclinical studies, and clinical trials. Nevertheless, the discrepancies between predictive data and the clinical significance on HDIs still exist, and different reports of HDIs add to rather than clarify the confusion regarding the use of herbal products and drug combinations. Here, we briefly review the underlying mechanisms causing PK-based HDIs, and more importantly summarize challenging issues, such as dose and treatment period effects, to be considered in study designs and interpretations of HDI evaluations.The properties of materials at the nanoscale open up new methodologies for engineering prospective materials usable in high-end applications. The preparation of composite materials with a high content of an active component on their surface is one of the current challenges of materials engineering. This concept significantly increases the efficiency of heterogeneous processes moderated by the active component, typically in biological applications, catalysis, or drug delivery. Here we introduce a general approach, based on laser-induced optomechanical processing of silver colloids, for the preparation of polymer surfaces highly enriched with silver nanoparticles (AgNPs). As a result, the AgNPs are firmly immobilized in a thin surface layer without the use of any other chemical mediators. We have shown that our approach is applicable to a broad spectrum of polymer foils, regardless of whether they absorb laser light or not. However, if the laser radiation is absorbed, it is possible to transform smooth surface morphology of the polymer into a roughened one with a higher specific surface area. link2 Analyses of the release of silver from the polymer surface together with antibacterial tests suggested that these materials could be suitable candidates in the fight against nosocomial infections and could inhibit the formation of biofilms with a long-term effect.Antidesma bunius (L.) spreng (Mamao) is widely distributed in Northeastern Thailand. Antidesma bunius has been reported to contain anthocyanins, which possess antioxidant and antihypertensive actions. However, the antidiabetic and antiglycation activity of Antidesma bunius fruit extract has not yet been reported. In this study, we investigated the inhibitory activity of anthocyanin-enriched fraction of Antidesma bunius fruit extract (ABE) against pancreatic α-amylase, intestinal α-glucosidase (maltase and sucrase), protein glycation, as well as antioxidant activity. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) chromatogram revealed that ABE contained phytochemical compounds such as cyanidin-3-glucoside, delphinidin-3-glucoside, ellagic acid, and myricetin-3-galactoside. ABE inhibited intestinal maltase and sucrase activity with the IC50 values of 0.76 ± 0.02 mg/mL and 1.33 ± 0.03 mg/mL, respectively. Furthermore, ABE (0.25 mg/mL) reduced the formation of fluorescent AGEs and the level of Nε-carboxymethyllysine (Nε-CML) in fructose and glucose-induced protein glycation during four weeks of incubation. During the glycation process, the protein carbonyl and β-amyloid cross structure were decreased by ABE (0.25 mg/mL). In addition, ABE exhibited antioxidant activity through DPPH radical scavenging activity and Trolox equivalent antioxidant capacity (TEAC) with the IC50 values 15.84 ± 0.06 µg/mL and 166.1 ± 2.40 µg/mL, respectively. Meanwhile, ferric reducing antioxidant power (FRAP) showed an EC50 value of 182.22 ± 0.64 µg/mL. The findings suggest that ABE may be a promising agent for inhibiting carbohydrate digestive enzyme activity, reducing monosaccharide-induced protein glycation, and antioxidant activity.Organic Rankine cycle (ORC) power generation is an effective way to convert medium and low temperature heat into high-grade electricity. In this paper, the subcritical saturated organic Rankine cycle system with a heat source temperature of 100~150 °C is studied with four different organic working fluids. The variations of the exergy efficiencies for the single-stage/two-stage systems, heaters, and condensers with the heat source temperature are analyzed. Based on the condition when the exergy efficiency is maximized for the two-stage system, the effects of the mass split ratio of the geothermal fluid flowing into the preheaters and the exergy efficiency of the heater are studied. The main conclusions include The exergy efficiency of the two-stage system is affected by the evaporation temperatures of the organic working fluid in both the high temperature and low temperature cycles and has a maximum value. link3 Under the same heat sink and heat source parameters, the exergy efficiency of the two-stage system is larger than that of the single-stage system.
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