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Circ_USP36 silencing attenuates oxidized low-density lipoprotein-induced disorder in endothelial tissues in illness by way of mediating miR-197-3p/ROBO1 axis.
The incorporation of children into urban sound environment research may be able to generate new results in terms of children's understanding of their sound environment. Moreover, sound environment policies can be developed from and for children.Although previous evidence suggests that happiness is lower among individuals with obesity, research on the correlates of subjective well-being (SWB) is warranted to increase our knowledge. We aim to explore excess weight (i.e., measured and self-reported body mass index (BMI)), body image and satisfaction, self-stigma, positivity, and happiness among Spanish adults with overweight or obesity. We further aim to investigate the predictors of SWB in this sample. A convenience sample of 100 individuals with excess weight completed self-reports on the study variables and were weighed and their height measured. On average, the participants reported body perceptions revealing minor excessive weight, moderate body satisfaction, low-to-moderate weight-related stigma, and elevated positivity and happiness. BMI and gender/sex independently affected these variables, but there were no significant interaction effects. Furthermore, individuals with overweight or obesity with higher body satisfaction and elevated positivity were more likely to report being happy, independent of their age, gender/sex, weight, and weight-related stigma. Mediation effects were found for body satisfaction and positivity in the relationship between weight and happiness. Moreover, positive orientation suppressed the pervasive influence of stigma on SWB. Our findings confirm the key role of body image dimensions and weight-related stigma for happiness and add support to the relevance of positivity for overall well-being of individuals with excess weight. These results may inform obesity management actions focused on inclusive aesthetic models, combating social stigmatization and enhancing positivity for a flourishing and fulfilling life.Over the last years, nontuberculous mycobacteria (NTM) have emerged as important human pathogens. Infections caused by NTM are often difficult to treat due to an intrinsic multidrug resistance for the presence of a lipid-rich outer membrane, thus encouraging an urgent need for the development of new drugs for the treatment of mycobacterial infections. Efflux pumps (EPs) are important elements that are involved in drug resistance by preventing intracellular accumulation of antibiotics. A promising strategy to decrease drug resistance is the inhibition of EP activity by EP inhibitors (EPIs), compounds that are able to increase the intracellular concentration of antimicrobials. Recently, attention has been focused on identifying EPIs in mycobacteria that could be used in combination with drugs. The aim of the present review is to provide an overview of the current knowledge on EPs and EPIs in NTM and also, the effect of potential EPIs as well as their combined use with antimycobacterial drugs in various NTM species are described.The university stage comprises a very important and vital period in the modification of students' lifestyles, and these changes can affect their self-concept. Caspases apoptosis The excessive use of technology today can also influence the formation of their identity. The aim of this study is to analyze the relationship between self-concept and the use of the smartphone by university students in terms of gender. The sample included 253 students (mean age 21.39 ± 3.27) of the Primary Education Degree of the University of Jaén (106 men and 147 women). A questionnaire was used to unify several instruments a sociodemographic questionnaire, a Self-Concept Form-5 questionnaire (AF-5), and a questionnaire on cell phone-related experiences (CERM). The results show the existence of significant differences between both genders in the academic, emotional, and social dimensions of self-concept, with women showing a greater academic self-concept and men showing an emotional and physical one. Regarding the use of the smartphone in relation to self-concept, significant differences are found in the academic and emotional dimensions depending on the degree of use. In addition, in relation to the use of the smartphone, it has been detected that half of the students present potential problems. It is concluded that there is a relationship between both constructs, especially the academic and emotional self-concept.Environmentally friendly polymer blends between post-consumer PET-G and bio-based poly(ethylene 2,5 furanoate) (PEF) have been prepared. The PET-G granules were obtained from the post-consumer glycol-modified poly(ethylene terephthalate) PET-G foils from Nicrometal S.A. as a result of materials recycling. PEF was synthesized from dimethyl furan-2,5-dicarboxylate and 1,2-ethylene glycol (BioUltra) by a two-stage melt polycondensation process. According to the calculations followed by Hoy's method, one has studied the miscibility of the components in the blend. The molecular structure of PET-G/PEF blends was analyzed by Fourier Transform Infrared Spectroscopy (FTIR) spectroscopy, while the morphology of the blends was determined by Scanning Electron Microscopy (SEM). To evaluate phase transition temperatures, as well as the thermal effects in PET-G/PEF blends, Differential Scanning Calorimetry (DSC), Dynamic Mechanical Thermal Analysis (DMTA), and Thermogravimetric Analysis (TGA), were performed. Tensile tests revealed that along with an increase in the amount of PEF, an increase in Young's modulus was observed. Besides, the existence of interfacial interactions between polymers, especially in the case of PET-G/PEF 80/20, enabling the PET-G chains to form a network structure with the PEF by reacting with their functional groups, allows observation of a synergistic effect in the improvement of thermal stability and water absorption.Background Population ageing is a worldwide phenomenon that could influence health policy effectiveness. This research explores the impact of age structural transitions on copayment policy responses under Taiwan's National Health Insurance (NHI) system. Methods The time-varying parameter vector autoregressive model was applied to create two measures of the copayment policy effectiveness, and multiple linear regression models were used to verify the nonlinear effect of age structural transitions on copayment policy responses. Results Our results show that copayment policy effectiveness (in terms of the negative response of medical center outpatient visits to upward adjustments in copayment) is positively correlated with the proportions of the population in two older age groups (aged 55-64 and ≥ 65) and children (age less then 15), but negatively correlated with the proportion of the population that makes up most of the workforce (aged 15‒54). These tendencies of age distribution, which influence the responses of medical center outpatient visits to copayment policy changes, predict that copayment policy may have a greater influence on medical center outpatient utilization in an ageing society.
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