Notes

Fast continuing development of aortic stenosis within a 3-month-old baby with bicuspid aortic control device and DeSanto-Shinawi malady.
To control the activity of photodynamic agents by pH, an electron donor-connecting cationic porphyrin, meso-(N',N'-dimethyl-4-aminophenyl)-tris(N-methyl-p-pyridinio)porphyrin (DMATMPyP), was designed and synthesized. The photoexcited state (singlet excited state) of DMATMPyP was deactivated through intramolecular electron transfer under a neutral condition. The pKa of the protonated DMATMPyP was 4.5, and the fluorescence intensity and singlet oxygen-generating activity increased under an acidic condition. Furthermore, the protonation of DMATMPyP enhanced the biomolecule photooxidative activity through electron extraction. Photodamage of human serum albumin (HSA) was observed under a neutral condition because a hydrophobic HSA environment can reverse the deactivation of photoexcited DMATMPyP. However, an HSA-damaging mechanism of DMATMPyP under a neutral condition was explained by singlet oxygen production. Therefore, it is indicated that the protein photodamaging activity of DMATMPyP goes into an OFF state under a neutral hypoxic condition. Under an acidic condition, the HSA photodamaging quantum yield by DMATMPyP through electron extraction could be preserved in the presence of a singlet oxygen quencher. Photooxidation of nicotinamide adenine dinucleotide by DMATMPyP was also enhanced under an acidic condition. This study demonstrated the concept of using pH to control photosensitizer activity via inhibition of the intramolecular electron transfer deactivation and enhancement of the oxidative activity through the electron extraction mechanism. Specifically, biomolecule oxidation through electron extraction may play an important role in photodynamic therapy to treat tumors under a hypoxic condition.Sustainable development is a worldwide concern. This work mainly focuses on the reuse of the combustion products of calcium carbide and the influence of different kinds of copper on the acetylene carbonylation reaction. A series of catalysts were prepared by heating the precursors under various atmospheres (air, hydrogen, and nitrogen). The X-ray diffraction and the X-ray photoelectron spectroscopy have been analyzed regarding copper species composition and content in catalysts. The result of the Cu+-promoted reaction was in good agreement with the conducted density functional theory analysis, and we speculate that Cu+ promotes the transfer of electrons in the reaction. Transmission electron microscopy and elemental mapping evaluation confirmed the difference in Cu dispersion. Characterization of catalysts using temperature programmed desorption and pyridine Fourier-transform infrared revealed differences in their acidity. Acidity was found to be favorable for acetylene carbonylation. Selectivity and yield of the CuAlZn-LDO(N) catalyst at 225 °C were 73 and 70%, respectively, and the catalyst showed good stability over two consecutive cycles of reuse.After oil and gas well drilling, they should be cased and cemented to ensure the stability of the wellbore and to isolate the trouble zones. To achieve these jobs, several additives are incorporated into the cement slurry to improve the cement matrix durability, especially at temperatures above 230 F. The tire waste material is an industrial waste that comes from automobile tires. The purpose of this work is to investigate the prospect of utilizing tire waste in oil-well cement under high-temperature and high-pressure conditions of 292 F and 3000 psi. Three cement samples with different concentrations of the tire waste material were prepared. The effects of tire waste on the cement rheological properties, elastic and failure parameters, and permeability were examined. The results showed that adding 0.3% by weight of cement (BWOC) of the tire waste material considerably improved the cement to the cement slurry and cement matrix properties, and it decreased the cement plastic viscosity by 53.1% and increased its yield point by 142.4% compared to the base cement. The cement samples with 0.3% BWOC of tire waste have Young's modulus which is 10.8% less than that of the base cement and Poisson's ratio of 14.3% greater than that of the base cement. By incorporating 0.3% of the tire waste, both compressive and tensile strengths of the cement increased by 48.3 and 11.7%, respectively, compared with those of the base cement. The cement permeability was decreased by 66.0% after adding 0.3% of the tire waste. Besides the improvement in the properties of cement, the use of the tire waste material has other economical and environmental advantages because these are very cheap materials dominant in our life.Traditional methods for detection of lead ions in water samples are costly and time-consuming. In this work, an accurate smartphone-based colorimetric sensor was developed utilizing a novel machine learning algorithm. In the presence of Pb2+ ions in the solution of specifically functionalized gold nanoparticles, the color of solution turns from red to purple. Indeed, the color variation of the solution is proportional to Pb2+ concentration. The smartphone camera captures the corresponding color change, and the image is processed by an efficient artificial intelligence protocol. The nonlinear regression approach was used for concentration estimation, in which the parameters of the proposed model are obtained using a new feature extraction algorithm. In prediction of Pb2+ concentration, the average absolute error and root-mean-square error were 0.094 and 0.124, respectively. The influence of pH of the medium, temperature, oligonucleotide concentration, and reaction time on the performance of the proposed sensor was carefully investigated and understood to achieve the best sensor response. This novel sensor exhibited good linearity for the detection of Pb2+ in the concentration range of 0.5-2000 ppb with a detection limit of 0.5 ppb.In this study, the synthesis of N-alkyl-2-halophenazin-1-ones has been established. Six N-alkyl-2-halophenazin-1-ones, including WS-9659 B and marinocyanins A and B, were synthesized by the direct oxidative condensation of 4-halo-1,2,3-benzenetriol with the corresponding N-alkylbenzene-1,2-diamines. PFI-2 ic50 One of the most significant features of the present method is that it can be successfully applied to the synthesis of N-alkyl-2-chlorophenazin-1-ones. The traditional chlorination of N-alkyl-phenazin-1-ones with N-chlorosuccinimide selectively occurs at the 4-position to afford the undesired N-alkyl-4-chlorophenazin-1-ones. Our synthetic route successfully circumvents this problem, culminating in the first chemical synthesis of WS-9659 B. The cytotoxicity of six N-alkyl-2-halophenazin-1-ones and three N-alkylphenazin-1-ones against human promyelocytic leukemia HL-60, human lung cancer A549, and normal MRC-5 cells was evaluated. Among the compounds tested in this study, 2-chloropyocyanin possesses significant selectivity toward A549 cells.
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