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HYPOTHESIS Dried blood droplet morphology may potentially serve as an alternative biomarker for several patho-physiological conditions. The deviant properties of the red blood cells and the abnormal composition of diseased samples are hypothesized to manifest through unique cell-cell and cell-substrate interactions leading to different morphological patterns. Identifying distinctive morphological trait from a large sample size and proposing confirmatory explanations are necessary to establish the signatory pattern as a potential biomarker to differentiate healthy and diseased samples. EXPERIMENTS Comprehensive experimental investigation was undertaken to identify the signatory dried blood droplet patterns. The corresponding image based analysis was in turn used to differentiate the blood samples with a specific haematological disorder "Thalassaemia" from healthy ones. Relevant theoretical analysis explored the role of cell-surface and cell-cell interactions pertinent to the formation of the distinct dried patterns. FINDINGS The differences observed in the dried blood patterns, specifically the radial crack lengths, were found to eventuate from the differences in the overall interaction energies of the system. A first-generation theoretical analysis, with the mean field approximation, also confirmed similar outcome and justified the role of the different physico-chemical properties of red blood cells in diseased samples resulting in shorter radial cracks. The supercapacitive performance of high-rate capacity and long-term cycling stability is still a big challenge for electroactive materials. Herein, Ni and Zn co-substituted Co carbonate hydroxide (NiZn-CoCH) flowers array is self-assembled on nickel foams (NFs) using l-ascorbic acid as a nanostructure inducer. The NiZn-CoCH flowers, consisting of silk-like nanosheets, are deservedly large electrode-electrolyte contact area and suitable ion-diffusion channel. The nanostructure and Ni and Zn co-substitution significantly improve energy storage performance. This electrode exhibits a high specific capacitance of 2020.8 F g-1 at 1 A g-1 with high-rate capacity (remain 80.2% at 10 A g-1) and 5000-cycle stability (almost unchanged after 1500 cycles at 10 A g-1). Additionally, an assembled asymmetric supercapacitor (ASC) device of NiZn-CoCH//activated carbon (AC) achieves a high energy density of 29.6 Wh kg-1 at a power density of 375 W kg-1 and only a 0.5% decrease of the capacitance after 2500 cycles. This facile and novel preparation method, using l-ascorbic acid, may be promising for industrial production of electroactive materials for the high-performance energy storage and conversion devices. BACKGROUND AND OBJECTIVE As Computed Tomography scans are an essential medical test, many techniques have been proposed to reconstruct high-quality images using a smaller amount of radiation. One approach is to employ algebraic factorization methods to reconstruct the images, using fewer views than the traditional analytical methods. However, their main drawback is the high computational cost and hence the time needed to obtain the images, which is critical in the daily clinical practice. For this reason, faster methods for solving this problem are required. SB-297006 CCR antagonist METHODS In this paper, we propose a new reconstruction method based on the QR factorization that is very efficient on affordable equipment (standard multicore processors and standard Solid-State Drives) by using Out-Of-Core techniques. RESULTS Combining both affordable hardware and the new software proposed in our work, the images can be reconstructed very quickly and with high quality. We analyze the reconstructions using real Computed Tomography images selected from a dataset, comparing the QR method to the LSQR and FBP. We measure the quality of the images using the metrics Peak Signal-To-Noise Ratio and Structural Similarity Index, obtaining very high values. We also compare the efficiency of using spinning disks versus Solid-State Drives, showing how the latter performs the Input/Output operations in a significantly lower amount of time. CONCLUSIONS The results indicate that our proposed me thod and software are valid to efficiently solve large-scale systems and can be applied to the Computed Tomography reconstruction problem to obtain high-quality images. V.The frequent occurrence of pharmaceuticals and personal care products (PPCPs) in domestic wastewater has caused great concern. In this study, the removal of two typical pharmaceuticals (Roxithromycin, ROX; Sulfamethoxazole, SMZ) in aerobic granular sludge (AGS) reactors was investigated under condition of different C/N (carbon to nitrogen) ratios. Results showed that higher removal efficiencies of ROX and SMZ (95.2 % and 92.9 %) were achieved in the AGS reactor fed with low C/N influent. Batch experiments further revealed that the removal of ROX was influenced by the adsorption ability of the AGS while SMZ removal was mainly enhanced by biodegradation process. Analysis of extracellular polymeric substances (EPS) showed that the humic acid-like substances were enriched under low C/N condition, which was in accordance with dynamic change of microbial community. The microbes, like Thauera spp. and Xanthomonadaceae, were highly enriched in the reactor with high nitrogen loading rate and functioned as refractory organics degrader. Overall, the AGS process could achieve enhanced pharmaceuticals removal performance by the regulation of microbial community under low C/N influent, which provides insights into a feasible solution for simultaneous removal of nitrogen and trace organic pollutants in AGS reactor. Chlorothalonil (CHT) is widely used in agriculture as a fungicide and has been detected in various ecosystems along with its degradation products. A primary intermediate product of degradation, 4-hydroxychlorothalonil (4-OH-CHT) has demonstrated toxic effects on aquatic organisms. However, the toxic effects of 4-OH-CHT on human health and the impacts of environmental factors on the toxicity remain unclear. To understand the environmental modification on the toxicity of 4-OH-CHT to human health, we used a three-dimensional human skin culture model. 4-OH-CHT and irradiated 4-OH-CHT were applied to the model for the dermatoxicity analyses. Although neither the 4-OH-CHT nor the irradiated 4-OH-CHT inhibited the cell proliferation, the 4-OH-CHT significantly attenuated the keratinocyte migration by 26% at a concentration of 20 ppb and by 44 % at 100 ppb. The 4-OH-CHT also demonstrated inhibitory effects on keratinocyte differentiation at both 20 ppb and 100 ppb. In contrast, photodegraded 4-OH-CHT did not show inhibitory effects on the migration and differentiation of the keratinocytes at any concentration.
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