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Assessing the actual reproducibility regarding CBCT-derived radiomics characteristics by using a book three-dimensional printed phantom.
Enzyme subunit interfaces have remarkable potential in drug design as both target and scaffold for their own inhibitors. We show an evolution-driven strategy for the de novo design of peptide inhibitors targeting interfaces of the Escherichia coli FoF1-ATP synthase as a case study. The evolutionary algorithm ROSE was applied to generate diversity-oriented peptide libraries by engineering peptide fragments from ATP synthase interfaces. The resulting peptides were scored with PPI-Detect, a sequence-based predictor of protein-protein interactions. Two selected peptides were confirmed by in vitro inhibition and binding tests. The proposed methodology can be widely applied to design peptides targeting relevant interfaces of enzymatic complexes.
Gantry-free radiation therapy systems utilizing patient rotation would be simpler and more cost effective than the conventional gantry-based systems. Such a system could enable the expansion of radiation therapy to meet global demand and reduce capital costs. Recent advances in adaptive radiation therapy could potentially be applied to correct for gravitational deformation during horizontal patient rotation. This study aims to quantify the pelvic organ motion and the dosimetric implications of horizontal rotation for prostate intensity-modulated radiation therapy (IMRT) treatments.

Eight human participants who previously received prostate radiation therapy were imaged in a clinical magnetic resonance imaging (MRI) scanner using a bespoke patient rotation system (PRS). The patients were imaged every 45 degrees during a full roll rotation (0-360 degrees). Whole pelvic bone, prostate, rectum, and bladder motion were compared to the supine position using dice similarity coefficient (DSC) and mean absolute suron for each PRS couch angle to account for anatomical deformations further improves the PTV coverage.
Pelvic bone and internal organ motion are present during patient rotation. Rigid PTV-guided alignment to the prostate will be a requirement if prostate IMRT is to be safely delivered using patient rotation. Plan re-optimization for each PRS couch angle to account for anatomical deformations further improves the PTV coverage.This article explores the development of an interdisciplinary Geriatric Engineering 5-year Bachelor of Science degree program. The process evolved over 5 years and began with exploring the need, precedents, and data acquisition from target individuals 60 to 92 years of age. The economics of aging necessitates training engineers to design and implement systems that drastically reduce costs. The literature search confirmed the need for medical and engineering collaboration. The precedents for a medical-engineering curriculum were found to exist in several graduate MD/MS Engineering programs. Finally, data were gathered from several hundred over 60-year olds, via a research questionnaire and interviews that supported that technology assistance to promote independent living was desired by a significant portion of older individuals. With confirmatory data in hand, geriatric engineering courses were introduced in 2017 at an engineering college. Feedback of more than 100 students who completed these courses was positive. An Advisory Board, composed of medical companies, hospitals, and target population individuals, supported a Geriatrics Engineering minor. The college's undergraduate curriculum committee then established a minor in Geriatric Engineering in 2019, as the next logical step in the process toward developing a bachelor's degree. In conclusion, student feedback from several years of Geriatric Engineering courses, data from individuals over 60 and an advisory board support the next step of creating a Geriatric Engineering Bachelor's degree. Student evaluations/perceptions of the courses were positive. Data and feedback indicate that there is a need for a dedicated undergraduate Geriatric Engineering program.Nonlinear electrokinetics (EK), specifically electrophoresis of the second kind, dielectrophoresis (DEP) and electrorotation (EROT), have gained significant interest recently for their flexibility and labeless discriminant manner of operation. The current applications of these technologies are a clear advancement from what they were when first discovered, but also still show strong signs of future growth. The present review article presents a discussion of the current uses of microscale nonlinear EK technologies as analytical, sensing, and purification tools for microorganisms. CX-3543 mouse The discussion is focused on some of the latest discoveries with various nonlinear EK microfluidic techniques, such as DEP particle trapping and EROT for particle assessments, for the analysis of microorganisms ranging from viruses to parasites. Along the way, special focus was given to key research articles from within the past two years to provide the most up-to-date knowledge on the current state-of-the-art within the field of microscale EK, and from there, an outlook on where the future of the field is headed is also included.
Medical schools aim to admit talented learners who are honest, patient centered, and caring, in addition to possessing the required cognitive skills. The Association of American Medical Colleges (AAMC) describes core competencies for entering medical students in three categories science, preprofessional, and thinking and reasoning. The authors sought to determine desired characteristics of medical school applicants at a rural, community-based medical school in light of the published core competencies.

This qualitative study involved an analysis of data from discussion groups, all from a convenience sample of participants. The authors led the discussion groups, and large sticky note pads and pens were provided to scribe responses. Group members were given the prompt, "What do you see as traits or characteristics of your ideal doctor?" We used a content analysis approach to analyze the data.

The total number of responses across groups was 243, representing 15 unique characteristics. The 15 characteristicsncies for rural medical schools to consider for entering medical students.
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