Notes

Searching the actual helical balance inside a VEGF-mimetic peptide.
A total of fifty-five soil samples were collected from four locations, namely, residential, industrial, dumpsite, and sewage in Agbara industrial estate, Ogun state, Nigeria. The samples were analyzed using a high purity germanium detector (HPGe) to measure the activity concentration of radionuclides. Background radiation measurements were also taken at each point where soil samples were collected using Geiger Muller (GM) counter. The mean activity concentrations measured in the soil samples were 171.33 for 40K, 9.11 for 232Th, and 5.05 for 226Ra in Bq/kg. The mean absorbed dose rate in the air due to radionuclides (40K, 232Th, and 226Ra) in the soil is calculated to be 14.77 nGy/h, and the mean annual effective dose equivalent (AEDE) is 0.02 mSv/year. The mean equivalent dose rate (EDR) from GM counter for background radiation is 0.22 μSv/h, and the mean annual effective dose rate (AEDR) is 0.39 mSv/year. These values are below the world average values, except EDR and AEDR with mean values higher than the world standard. The comparison of radiation dose rates revealed that radionuclides contributed 6.7% to background radiation. The equivalent dose (EDorgans) for various organs of the body was calculated, and results showed that values do not pose any immediate health hazard. The excess lifetime cancer risk (ELCR) due to exposure to background radiation indicated that the dwellers and industrial workers in the study area may develop cancer over a lifetime due to accumulated dose.
Diabetes and hypertension are two common comorbidities that affect breast cancer patients, particularly Black women. Disruption of chronic disease management during cancer treatment has been speculated. Therefore, this study examined the implementation of clinical practice guidelines and health outcomes for these comorbidities before and during cancer treatment.

We used a population-based, prospective cohort of Black women diagnosed with breast cancer (2012-2016) in New Jersey (n = 563). Chronic disease management for diabetes and hypertension was examined 12 months before and after breast cancer diagnosis and compared using McNemar's test for matched paired and paired t tests.

Among this cohort, 18.1% had a co-diagnosis of diabetes and 47.2% had a co-diagnosis of hypertension. Implementation of clinical practice guidelines and health outcomes that differed in the 12 months before and after cancer diagnosis included lipid screening (64.5% before versus 50.0% after diagnosis; p = 0.004), glucose screeninncer survival disparity, strategies are needed to improve chronic disease management during cancer, especially for Black women who bear a disproportionate burden of chronic diseases.Manual dexterity and phonological decoding involve the posterior parietal cortex, which controls location coding for visually guided actions, as well as a large fronto-cerebellar network. We studied the relationship between manual dexterity and reading ability in adult typical readers. Two measurements of manual dexterity were collected to index the procedural learning effect. A linear regression model demonstrated that phonological short-term memory, manual dexterity at time 1 and procedural learning of manual dexterity predicted phonological decoding speed. Similar results were found when left-hand dexterity at time 1 and procedural learning dexterity were entered last. The better one's phonological decoding skill was, the less fluent their manual dexterity was, suggesting a recycle from object-location to letter-location coding. However, the greater the procedural learning, the faster phonological decoding was, suggesting that larger plasticity of object-location coding was linked to better letter-location coding. An independent role of the interhemispheric connections or of the right posterior parietal cortex is also suggested.Previous studies have shown that money possesses affective properties even when it is not at stake within a given task. Smaller economic values are generally perceived as less arousing and neutral in valence, whereas larger ones are perceived as more arousing and positive in valence. Moreover, numerical cognitive processes seem to be less prominent than affective ones in the way we perceive economic values. To shed light on the basic affective components of monetary values, we ran three experiments on the perception of banknotes to test (i) whether banknotes with different values (5€ and 100€) trigger different emotional states, (ii) if values are horizontally mapped based on their valence, rather than on their numerical magnitude, and (iii) whether the lateralized sight (in the left or right visual field) of a positive (higher) monetary value interferes with the classification of a negative stimulus. Results showed a coherent pattern that corroborates the idea that money is indeed an affective stimulus, even when it is not at stake within the task. A higher monetary value was shown (i) to have intrinsic rewarding properties that influence the evaluation of a subsequent target, (ii) to be mentally mapped on the right side, which is related to positive approaching of affective stimuli in right-handers, and (iii) to be in conflict with negative-withdrawing targets, but only when the values were presented on the right-positive side of respondents. Results are discussed considering existing theories of the psychological value of money, highlighting the hedonic characteristics of this special affective stimulus.Humans are unique in the way they understand the causal relationships between the use of tools and achieving a goal. The idea at the core of the present research is that tool use can be considered as an instance of problem-solving situations supported by technical reasoning. In an eye-tracking study, we investigated the fixation patterns of participants (N = 32) looking at 3D images of thematically consistent (e.g., nail-steel hammer) and thematically inconsistent (e.g., scarf-steel hammer) object-tool pairs that could be either "hazardous" (accidentally electrified) or not. ALW II-41-27 research buy Results showed that under thematically consistent conditions, participants focused on the tool's manipulation area (e.g., the handle of a steel hammer). However, when electrified tools were present or when the visual scene was not action-prompting, regardless of the presence of electricity, the tools' functional/identity areas (e.g., the head of a steel hammer) were fixated longer than the tools' manipulation areas. These results support an integrated and reasoning-based approach to human tool use and document, for the first time, the crucial role of mechanical/semantic knowledge in tool visual exploration.Osteoarthritis (OA) is a chronic joint disease, which occurs in the elderly. The regulatory mechanisms of circRNAs were involved in the occurrence and development of various diseases. However, the potential regulatory network of circRNA in OA remains further research and clarification. The expression of circ_0114876 was increased in OA tissues and inhibition of circ_0114876 could induce cell viability and suppress inflammation as well as inhibit cell apoptosis in IL-1β induced CHON-001 cells. Circ_0114876 regulated TRAF2 expression via sponging miR-671 in CHON-001 cells. Down-regulated miR-671 expression could reverse the effects of low circ_0114876 expression on cell progression and inflammation in IL-1β induced CHON-001 cells. Overexpression of TRAF2 could weaken the promotion effects of high miR-671 expression on cell progression and inflammation in IL-1β induced CHON-001 cells. Circ_0114876 targeted miR-671 to regulate cell progression and inflammation via modulating TRAF2 expression in IL-1β induced CHON-001 cells, and played an important regulatory mechanism in IL-1β-induced chondrocyte injury, providing a novel diagnostics and therapeutics in OA.In an experiment with 114 children aged 9-12 years, we compared the ability to establish local and global coherence of narrative texts between auditory and audiovisual (auditory text and pictures) presentation. The participants listened to a series of short narrative texts, in each of which a protagonist pursued a goal. Following each text, we collected the response time to a query word that was either associated with a near or a distant causal antecedent of the final sentence. Analysis of these response times indicated that audiovisual presentation has advantages over auditory presentation for accessing information relevant for establishing both local and global coherence, but there are indications that this effect may be slightly more pronounced for global coherence.In the present study, we investigated how positive mood affects the formation of time-based event expectancies. After positive or neutral mood inductions, participants performed a binary choice response task in which two target stimuli (circle and square) and two pre-target intervals (800 and 1600 ms) appeared equally often. One of the targets was paired with the short interval and the other target with the long interval in 90% of the trials. We found that participants from the positive and neutral groups showed markedly different behavioral patterns of time-based expectancy. The time-based expectancy was restricted to shorter intervals for the positive group and to longer intervals for the neutral group. We propose that positive mood increases attentional prioritization of information that is temporally closer to us.How can we rethink 'rationality' in the wake of animal and artificial intelligence studies? Can nonhuman systems be rational in any nontrivial sense? In this paper, we propose that all organisms, under certain circumstances, exhibit rationality to a diverse degree and aspect in the sense of the standard picture (SP) Their inferential processes conform to logic and probability rules. We first show that according to Calvo and Friston (J R Soc Interface 14(131)20170096, 2017) and Orlandi (2018), all biological systems must embody a top-down process (active inference) to minimize free energy. Next, based on Maddy's (Second philosophy, Oxford University Press, Oxford, 2007; The logical must Wittgenstein on logic, Oxford University Press, Oxford, 2014) analysis, we argue that this inferential process conforms to logic and probability rules; thus, it satisfies the SP, which explains the rudimentary logic and arithmetic (e.g., categorizing and numbering) found among pigeons and mice. We also hold that the mammalian brain is only one among many ways of implementing rationality. Finally, we discuss data from microorganisms to support this view.This article explores the domain generality of hierarchical representation between linguistic and mathematical cognition by adopting the structural priming paradigm in an eye-tracking reading experiment. The experiment investigated whether simple arithmetic equations with high (e.g., (7 + 2) × 3 + 1)- or low (e.g., 7 + 2 × 3 + 1)- attachment influence language users' interpretation of Chinese ambiguous structures (NP1 + He + NP2 + De + NP3; Quantifier + NP1 + De + NP2; NP1 + Kan/WangZhe + NP2 + AP). On the one hand, behavioral results showed that high-attachment primes led to more high-attachment interpretation, while low-attachment primes led to more low-attachment interpretation. On the other hand, the eye movement data indicated that structural priming was of great help to reduce dwell time on the ambiguous structure. There were structural priming effects from simple arithmetic to three different structures in Chinese, which provided new evidence on the cross-domain priming from simple arithmetic to language.
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