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male). Victims' tendency to report an opposite-sex offender to the police was strongest in simple assaults and absent in aggravated assaults. We conclude that male and female victims' reporting behaviors were most consistent with gender norms that encourage the use of self-help violence and discourage police reporting in intragender assaults. Consistent with this explanation, self-help violence was negatively related to crime reporting in assaults. Victims were more likely to use self-help violence and avoid reporting to the police against a same-sex offender than an opposite-sex offender. Finally, the offender's gender had a relatively stronger influence on assault victims' decisions to use self-help violence than on victims' decisions to take no action against the offender (i.e., not reporting to the police or using self-help violence).Recent biomarker innovations hold potential for transforming diagnosis, prognostic modeling, and precision therapeutic targeting of traumatic brain injury (TBI). However, many biomarkers, including brain imaging, genomics, and proteomics involve vast quantities of high-throughput and high-content data. Management, curation, analysis and evidence synthesis of these data are not trivial tasks. In this review we discuss data management concepts, and statistical and data sharing strategies when dealing with biomarker data in the context of TBI research. We propose that application of biomarkers involves three distinct steps-discovery, evaluation and evidence synthesis. First complex/big data has to be reduced to useful data elements at the stage of biomarker discovery. Second, inferential statistical approaches must be applied to these biomarker data elements for assessment of biomarker clinical utility and validity. Lastly, synthesis of relevant research is required to support practice guidelines and enable health decisions informed by the highest quality, up-to-date evidence available. We focus our discussion around recent experiences from the International Traumatic Brain Injury Research (InTBIR) initiative, with a specific focus on 4 major clinical projects (TRACK-TBI, CENTER-TBI, CREACTIVE and ADAPT), which are currently enrolling subjects in North America and Europe. We discuss common data elements, data collection efforts, data-sharing opportunities and challenges, and examine the statistical techniques required to realize successful adoption and use of biomarkers in the clinic as a foundation for precision medicine in TBI.In 2016, Colombia's position regarding motorcyclist fatalities per 100,000 inhabitants was tenth worldwide and second in South America. In the seven years from 2012-2018, the proportion of deceased and injured motorcyclists among all road users was 50%. To analyse the significant aspects of the accident rate of motorcyclists in Colombia from 2016 to 2018 and estimate cost social value of motorcycle-related deaths. The global numbers of fatalities and injuries were compared to the Colombian context. Descriptive and inferential statistics were conducted to explore the association of fatal trauma and motorcycle accidents. P values and odds ratios were calculated. Bogotá, Cali, and Medellín were the cities with the most accidents. The month, day, time, age of the victims, and climatic conditions had a statistically significant association with the fatal trauma. Most victims were between the ages of 20-29 years. WH-4-023 cost Motorcycles were involved in more than 60% of accidents. The social cost of a life lost in a motorcycle accident was estimated at $2,418 million Colombian pesos (725,400 USD) per year. The establishment of countermeasures for the road safety of vulnerable users should focus on associated causal factors in order to develop strategies to effectively reduce the number of accidents.Theories on empathy have argued that feeling empathy for others is related to accurate recognition of their emotions. Previous research that tested this assumption, however, has reported inconsistent findings. We suggest that this inconsistency may be due to a lack of consideration of the fact that empathy has two facets empathic concern, namely the compassion for unfortunate others, and personal distress, the experience of discomfort in response to others' distress. We test the hypothesis that empathic concern is positively related to emotion recognition, whereas personal distress is negatively related to emotion recognition. Individual tendencies to respond with concern or distress were measured with the standard IRI (Interpersonal Reactivity Index) self-report questionnaire. Emotion recognition performance was assessed with three standard tests of nonverbal emotion recognition. Across two studies (total N = 431) anddifferent emotion recognition tests, we found that these two facets of affective empathy have opposite relations to recognition of facial expressions of emotions empathic concern was positively related, while personal distress was negatively related, to accurate emotion recognition. These findings fit with existing motivational models of empathy, suggesting that empathic concern and personal distress have opposing impacts on the likelihood that empathy makes one a better emotion observer.Global warming caused by anthropogenic activity is one of the serious problems today. In order to suppress the global warming, the shift from fossil fuel-based energy source to the nature-oriented sustainable energy is encouraged. In this concept paper, possible biomimetic engineering approach inspired by the efficient and sustainable natural energy utilization in living plants is demonstrated. The focal features in plants include (1) the light-harvesting and energy condensing apparatus, (2) water splitting O2 evolving apparatus, (3) storage of energy-related chemicals, and (4) reversal conversion of storage into the "energy in use" by meeting the demands. Demonstration of solar-driven chemical energy conversion was performed using a system consisted of (i) photovoltaic power-generating device, (ii) an electrochemical unit converting electric power into chemical energy, (iii) storage of H2, and (iv) polymer electrolyte cells converting H2 back to electricity by meeting the demands on site. The present concept paper presenting a technical perspective based on the plant-inspired knowledge (conceptual similarity between natural photosynthesis and solar-to-H2 conversion) is a fruit of interdisciplinary collaboration between the team of chemical energy conversion renown for the world highest record of solar-to-hydrogen conversion efficiency (24.4%, as of 2015) and a group of plant biologists.We describe a rare case of a patient with rapid onset, prominent cognitive and behavioral changes who presented to our rapidly progressive dementia program with symptoms ultimately attributed to bilateral basal ganglia infarcts involving the caudate heads. We review the longitudinal clinical presentation and neuropsychological testing for this patient, and discuss the implicated basal ganglia and frontal lobe neuroanatomy.We examined knowledge of Alzheimer's disease and related dementias (ADRD), resources, and research opportunities among older African American (AA) and Caucasian caregivers. A mixed methods design integrated qualitative (focus group) and quantitative (survey) data from Northwest Louisiana. Eight focus groups (59 adults, 92% female, 78% AA, 25% rural) revealed limited knowledge. Quantitative findings from 117 ADRD caregivers (83% female, 72% AA, 30% limited heath literacy, 27% low income) indicated participants obtained information from providers (54%), friends and relatives (32%), and the internet (37%). Barriers to care were cost (24%) and lack of family agreement (17%). Few families used adult daycare (8%) or support groups (28%). Concerns about research participation were violation of privacy (30%) and fear of patient distress (27%). Distrust of doctors was minimal (3%). Findings did not vary by race. There is a need for clear, literacy-appropriate information about ADRD, caregiver resources, and clinical trials.The review article focuses on free radicals and oxidative stress involved in ophthalmological diseases such as retinopathy, cataract, glaucoma, etc. Oxidative stress is considered as a key factor involved in the pathology of many chronic diseases including ophthalmic complication and inflammatory process. Oxidative stress and inflammation are closely related pathophysiological processes and are simultaneously found in many pathological conditions. The free radicals produced oxidize cellular components such as lipids and phospholipids leading to lipid peroxidation and trigger the onset of retinopathy. Cataract is a significant cause of visual disability and it is proposed that the high incidence is related to oxidative stress induced by continued intraocular penetration of light and consequent photochemical generation of free radical oxidants. Glaucoma is the leading cause of irreversible blindness and comprises a group of diseases characterized by progressive optic nerve degeneration. Oxidative injury and altered antioxidant defense mechanisms in glaucoma appear to play a role in the pathophysiology of glaucomatous neurodegeneration that is characterized by death of retinal ganglion cells. The UVB radiations through this way may cause a number of diseases like photo-keratitis, pterygium, damage to epithelium, edema, and corneal cell apoptosis.Abbreviations ROS reactive oxygen species; RNS reactive nitrogen species; O2. superoxide anion; H2O2 hydrogen peroxide;. OH hydroxyl radicals; ONOO-, ONO2- peroxynitrite; NO nitric oxide; IOP intraocular pressure; RGC retinal ganglion cells. WHO World Health Organization; IAPB International Agency for the Prevention of Blindness.OBJECTIVE Systemic lupus erythematosus (SLE) is a complex multi-systemic autoimmune disease with variable levels of activity that may wax and wane within the same patient over the years. In view of the scarcity of data about lupus in the East Malaysian population, we aimed to study the disease activity and damage index in patients with SLE hospitalized in a tertiary center in Sabah, East Malaysia. METHODS We retrospectively studied all patients with SLE admitted from 1 January 2013 to 31 December 2015. Demographic data, clinical features, treatment received, SLEDAI and SLICC/ACR (Systemic Lupus International Collaborating Clinics/American College of Rheumatology) criteria and outcomes were collected. RESULTS There were 108 patients studied whereby 88.9% were females. They had a mean age of 31.4 ± 11.02 years at admission and were multiethnic in origin. The mean number of ACR criteria for SLE was 5.03 ± 1.5 at the time of diagnosis. There were 158 hospitalizations during the 3 years. The main causes of hospitaion remained the main causes of admission and readmissions and was present in 44.4% of the mortalities in our cohort.Traumatic brain injury (TBI) can cause persistent cognitive changes and ongoing neurodegeneration in the brain. Accumulating epidemiological and pathological evidence implicates TBI in the development of Alzheimer's disease, the most common cause of dementia. Further, the TBI-induced form of dementia, called chronic traumatic encephalopathy, shares many pathological hallmarks present in multiple different diseases which cause dementia. The inflammatory and neuritic responses to TBI and dementia overlap, indicating that they may share common pathological mechanisms and that TBI may ultimately cause a pathological cascade culminating in the development of dementia. This review explores Australian pre-clinical research investigating the pathological links between TBI and dementia.
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