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Relative Preclinical Evaluation of HER2-Targeting ABD-Fused Affibody® Elements 177Lu-ABY-271 along with 177Lu-ABY-027: Effect regarding DOTA Placement on ABD Website.
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Bismuth germanate (BGO) shows good properties for PET applications, but was substituted by the development of faster crystals like Lutetium oxyorthosilicate (LSO) for time-of-flight PET (TOF-PET). Recent improvements in silicon photomultipliers (SiPM) and fast readout electronics make it possible to access the Cherenkov photon signal produced upon 511 keV interaction, which makes BGO a cost effective candidate for TOF-PET. Tails in the time delay distribution, however, remain a challenge. These are mainly caused by the high statistical fluctuation on the Cherenkov photons detected. To select fast events with a high detected Cherenkov photon number, the signal rise time of the SiPM was used for discrimination. The charge, time delay and signal rise time was measured for two different lengths of BGO crystals coupled to FBK NUV-HD SiPM and high frequency readout in a coincidence time resolution setup. The recorded events were divided into 5x5 categories based on the signal rise time and a time resolution of 200 ± 3 ps for 2×2×20 mm 3 and 117 ± 3 ps for 2×2×3 mm 3 was measured for the fastest 20% of the events (4% in coincidence). These good timing events can bring additional information in the image reconstruction in order to increase the SNR significantly, without spoiling the detector sensitivity. Putting all photopeak events together and correcting for the time bias introduced by different number of Cherenkov photons detected, a time resolution of 259 ± 3 ps for 20 mm long and 151 ± 3 ps for 3 mm long crystal was measured. For a small fraction of events sub-100 ps coincidence time resolution with BGO was reached for a 3 mm short pixel. Creative Commons Attribution license.Mesoporous n-i-p perovskite solar cells (PeSCs) demonstrate attractive potentials for obtaining high power conversion efficiencies (PCEs), by employing inorganic electron transport layers (ETLs). However, these ETLs composed of dual layers (a condense layer and a mesoporous layer) suffer composite process and high sintering temperature. Here, we demonstrate a simple and efficient process to improve the device performance of PeSCs by using a textured SnO2 film. RNA Synthesis inhibitor Self-aged sol-gel SnO2 solution after spin coating results in a textured structure without sacrificing the surface coverage. Excellent light trapping ability is achieved by optimizing the aged time of sol-gel SnO2 solution, which mimics the evolution of conventional mesoporous layer. Such SnO2 textured structure provides a large contact area for rapid charge extraction, and alleviates interfacial recombination loss. Therefore, this PeSC yields an optimal PCE of 19%, which is prominent in state-of-the-art SnO2-based devices. These results indicate that one-step solution processed SnO2 with textured structure offers a simple and efficient way to improve the device performance of PeSCs without a complex process. © 2020 IOP Publishing Ltd.Van der Waals heterostructures (vdWHs) based on two-dimensional (2D) materials are being studied extensively for their prospective applications in photodetectors. As the pristine WSe2/MoTe2 heterostructure is a type I (straddling gap) structure, it cannot be used as a photovoltaic device theoretically, although both WSe2 and MoTe2 have excellent photoelectric properties. The Fermi level of p-doped WSe2 is close to its valence band. The p-doped WSe2/MoTe2 heterostructure can perform as a photovoltaic device because a built-in electric field appears at the interface between MoTe2 and p-doped WSe2. Here, a 633 nm laser was used for scanning the surface of WSe2 in order to obtain the p-doped WSe2. X-ray photoelectron spectroscopy (XPS) and electrical measurements verified that p-type doping in WSe2 is produced through laser treatment. The p-type doping in WSe2 includes substoichiometric WOx and nonstoichiometric WSex. A photovoltaic device using p-doped WSe2 and MoTe2 was successfully fabricated. The band structure, light-matter reactions, and carrier-transport in the p-doped WSe2/MoTe2 heterojunction were analyzed. The results showed that this photodetector has an on/off ratio of ≈104, dark current of ≈1 pA, and response time of 72 μs under the illumination of 633 nm laser at zero bias (Vds = 0 V). The proposed p-doping method may provide a new approach to improve the performance of nanoscale optoelectronic devices. © 2020 IOP Publishing Ltd.Sulfur vacancy in MoS2 has been found to have an important influence on the performance of optoelectronic devices. Here, we study the effect of sulfur vacancy and O2 adsorption on the electronic and optical properties in the two-dimensional ferroelectric CuInP2S6. It is revealed that a defect state appears at the top of valence band with the presence of sulfur vacancy. However, when O2 is chemisorbed at sulfur vacancy, the defect state disappears. RNA Synthesis inhibitor The variation of charge state and charge transfer are calculated and discussed. Although the ferroelectricity is greatly suppressed with the presence of sulfur vacancy, the ferroelectric state can be recovered when the O2 is adsorbed. Within the framework of GW+BSE method, the optical absorption edge of CuInP2S6 monolayer exhibits a red-shift for the presence of sulfur vacancy, and further O2 adsorption gives rise to a blue-shift of the spectrum. Our findings have shown an effective way to improve the functionality of two-dimensional ferroelectrics via defect engineering. © 2020 IOP Publishing Ltd.The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia. However, the mechanism is still confused. An aging model, the senescence accelerated mouse-8 (SAMP8), was used in this study. Novel object recognition and the open field test results showed that oral administration of spermidine, spermine and rapamycin increased discrimination index, modified number, inner squares distance and times. Spermidine and spermine increased the activity of SOD, and decreased the level of MDA in the aging brain. Spermidine and spermine phosphorylate AMPK and regulate autophagy proteins (LC3, Beclin 1 and p62). Spermidine and spermine balanced mitochondrial and maintain energy for neuron, with the regulation of MFN1, MFN2, DRP1, COX IV and ATP. In addition, western blot results (Bcl-2, Bax and Caspase-3, NLRP3, IL-18, IL-1β) showed that spermidine and spermine prevented apoptosis and inflammation, and elevate the expression of neurotrophic factors, including NGF, PSD95and PSD93 and BDNF in neurons of SAMP8 mice.
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