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Diffuse Leukoplakia in the Vesica Ostium-Sparing inside Individual Addressed with Leuprorelin regarding Cancers of the breast.
Dual sign magnetoresistance (MR) and spin-glass state are achieved by stabilizing 120 Å thick La0.7Sr0.3MnO3 (LSMO) film on a (001) oriented Si substrate using pulsed sputtered plasma deposition method. The growth of the ZnO film on top of LSMO suppresses the Curie temperature around 30 K, and reduces the out-of-plane positive MR to zero. On increasing the paramagnetic ZnO film thickness, the out-of-plane negative MR and net magnetic moment increase with the same Curie temperature. At the same time, the band gap decreases, and is attributed to the grain size. The existence of the spin-glass state designates the presence of the non-collinear Mn ion spins, which formed because of the competing double exchange and superexchange interactions. The spin-glass state in the LSMO film is rich in the charge transfer driven localized strong antiferromagnetic coupling at the Si-LSMO interface. The localized strong antiferromagnetic coupling and spin-orbit coupling induced weak antilocalization favor positive MR and reduce the Curie temperature in LSMO. In contrast, the strong magnetic scattering and the loss of the 2D confinement of the charge carrier in LSMO-ZnO heterostructures favor the negative MR. Our investigations show that the technologically important interfacial magnetic coupling and magnetoresistance could be achieved in a bottom interface, and can be manipulated by the top interface of the semiconducting-ferromagnetic-semiconducting heterostructures.Raman hyperspectral imaging is a powerful method to obtain detailed chemical information about a wide variety of organic and inorganic samples noninvasively and without labels. However, due to the weak, nonresonant nature of spontaneous Raman scattering, acquiring a Raman imaging dataset is time-consuming and inefficient. In this paper we utilize a compressive imaging strategy coupled with a context-aware image prior to improve Raman imaging speed by 5- to 10-fold compared to classic point-scanning Raman imaging, while maintaining the traditional benefits of point scanning imaging, such as isotropic resolution and confocality. With faster data acquisition, large datasets can be acquired in reasonable timescales, leading to more reliable downstream analysis. On standard samples, context-aware Raman compressive imaging (CARCI) was able to reduce the number of measurements by ∼85% while maintaining high image quality (SSIM >0.85). Using CARCI, we obtained a large dataset of chemical images of fission yeast cells, showing that by collecting 5-fold more cells in a given experiment time, we were able to get more accurate chemical images, identification of rare cells, and improved biochemical modeling. For example, applying VCA to nearly 100 cells' data together, cellular organelles were resolved that were not faithfully reconstructed by a single cell's dataset.2.25Cr1Mo0.25V is a state-of the-art alloy used in the fabrication of modern hydrogenation reactors. Compared to the conventional 2.25Cr1Mo steel, the 2.25Cr1Mo0.25V steel exhibits a better performance, in particular higher hydrogen damage resistance. Previous experimental studies indicate that carbides in steels may be responsible for the hydrogen-induced damage. To gain a better understanding of the mechanism of such damage, it is essential to study hydrogen uptake in metal carbides. In this study, Density Functional Theory (DFT) is used to investigate the stability of chromium, molybdenum and vanadium carbides (CrxCy, MoxCy and VxCy) in the 2.25Cr1Mo0.25V steel. The stability of their corresponding interstitial hydrides was also explored. The results showed that Cr7C3, Mo2C and V6C5 are the most stable carbides in their respective metal-carbon (Cr-C, Mo-C and V-C) binary systems. Specifically, V6C5 shows the strongest hydrogen absorption ability because of its strong V-H and C-H ionic bonds. On the other hand, V4C3, whose presence in the alloy was established in experimental studies, is predicted to be stable as well, along with V6C5. Our findings indicate that the hydrogen absorption ability of V4C3 is higher than that of V6C5. Additionally, the charge and chemical bonding analyses reveal that the stability of the metal carbide hydrides strongly depends on the electronegativity of the metal. Due to the high electronegativity of V, vanadium carbides form the strongest ionic bonds with hydrogen, compared to those of Mo and Cr. The results from this study suggest that the unique capacity of accommodating hydrogen in the vanadium carbides plays an important role in improved hydrogen damage resistance of the 2.25Cr1Mo0.25V alloy in hydrogenation reactors.Two-dimensional van der Waals (vdW) crystals can sustain various types of polaritons with strong electromagnetic confinements, making them highly attractive for nanoscale photonic and optoelectronic applications. While extensive experimental and numerical studies have been devoted to the polaritons of the vdW crystals, analytical models are sparse. Particularly, applying the model to describe polariton behaviors that are visualized by state of the art near-field optical microscopy requires further investigations. In this study, we develop an analytical waveguide model to describe polariton propagations in vdW crystals. The dispersion contours, dispersion relations, and localized electromagnetic field distributions of polariton waveguide modes are derived. The model is verified by real-space optical nano-imaging and numerical simulation of phonon polaritons in α-MoO3, which is a vdW biaxial crystal. Although we focus on α-MoO3, the proposed model is valid for other polaritonic crystals within the vdW family given the corresponding dielectric substitutions. Our model therefore provides an analytical rationale for describing and understanding the localized electromagnetic fields in vdW crystals that are associated with polaritons.Ferroptosis therapy, which applies ferroptotic inducers to produce lethal lipid peroxidation and induce the death of tumor cells, is regarded as a promising therapeutic strategy for cancer treatment. However, there is still a challenge regarding how to increase reactive oxygen species (ROS) accumulation in the tumor microenvironment (TME) to enhance antitumor efficacy. Herein, we designed a nanosystem coated with the FDA approved poly(lactic-co-glycolic acid) (PLGA) containing ferrous ferric oxide (Fe3O4) and chlorin E6 (Ce6) for synergistic ferroptosis-photodynamic anticancer therapy. The Fe3O4-PLGA-Ce6 nanosystem can dissociate in the acidic TME to release ferrous/ferric ions and Ce6. Then, the Fenton reaction between the released ferrous/ferric ions and intracellular excess hydrogen peroxide can occur to produce hydroxyl radicals (˙OH) and induce tumor cell ferroptosis. The released Ce6 can increase the generation and accumulation of ROS under laser irradiation to offer photodynamic therapy, which can boost ferroptosis in 4T1 cells. Moreover, magnetic monodisperse Fe3O4 loading provides excellent T2-weighted magnetic resonance imaging (MRI) properties. The Fe3O4-PLGA-Ce6 nanosystem possesses MRI ability and highly efficient tumor suppression with high biocompatibility in vivo due to the synergism of photodynamic and ferroptosis antitumor therapies.Transition-metal compounds are attractive for catalysis and other fields but generally suffer from aggregating propensity, circuitous diffusion pathways and limited reaction activities. Two-dimensional (2D) quasi-nanosheets composed of nano-sized crystals with precisely controlled stoichiometric features can readily overcome these problems. We here construct a variety of interconnected 2D holey arrays composed of single-crystal nitrogen-doped nanoparticles through a coordination-driving deposition and sequential etching (CDSE) strategy, independent of the phases and stoichiometries of target crystals. The strong coordination between the empty orbits of metal ions and n-orbits of pyridine nitrogen in conjugated carbon nitride (CN) confines the growth of metal species in 2D form. Meanwhile, the eighteen-membered-rings of CN coupled with metal ions can be thermally etched preferentially as a result of weakened N[double bond, length as m-dash]C bonds caused by forming the TiO2+-N6 configuration. The as-obtained metal oxide quasi-nanosheets and their phosphatized counterparts show impressive activities in photocatalysis and electrocatalysis owing to the synergetic effect of geometric and compositional features. Our CDSE strategy offers a versatile platform, with which to explore the properties and functions of hierarchical architectures.Melanoma is one of the highly malignant skin tumors, the incidence and death of which continue to increase. The hypoxic microenvironment drives tumor growth, progression, and heterogeneity; it also triggers a cascade of immunosuppressive responses and affects the levels of T cells, macrophages, and natural killer cells. Here, we aim to develop a hypoxia-based gene signature for prognosis evaluation and help evaluate the status of hypoxia and the immune microenvironment in melanoma. Based on the data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database, we performed integrated bioinformatics to analyze the hypoxia-related genes. Using Lasso Cox regression, a hypoxia model was constructed. The receiver operating characteristic and the Kaplan-Meier curve were used to evaluate the predictive capacity of the model. With the CIBERSORT algorithm, the abundance of 22 immune cells in the melanoma microenvironment was analyzed. A total of 20 hypoxia-related genes were significantly related to prognosis in the log-rank test. Lasso regression showed that FBP1, SDC3, FOXO3, IGFBP1, S100A4, EGFR, ISG20, CP, PPARGC1A, KIF5A, and DPYSL4 displayed the best features. Based on these genes, a hypoxia model was established, and the area under the curve for the model was 0.734. Furthermore, the hypoxia score was identified as an independent prognostic factor. Besides, the hypoxia score could also predict the immune microenvironment in melanoma. Down-regulated activated CD4 memory T cells, CD8 T cells, and M1-like macrophages, and up-regulated Tregs were observed in patients with a high hypoxia score. The hypoxia-related genes were identified, and the hypoxia score was found to be a prognostic factor for overall survival and a predictor for the immune microenvironment. Our findings provide new ideas for evaluation and require further validation in clinical practice.The Cu(ii) ions in [(C2H5)3NH]2Cu2(C2O4)3 form a hyperhoneycomb lattice and show no indication of long-range magnetic order down to 60 mK. It has therefore been suggested that [(C2H5)3NH]2Cu2(C2O4)3 is a three dimensional quantum spin liquid. We construct a tight-binding model of [(C2H5)3NH]2Cu2(C2O4)3 from Wannier orbital overlaps. Including interactions within the Jahn-Teller distorted Cu-centered eg Wannier orbitals leads to a highly anisotropic effective Heisenberg model. check details We show that this anisotropy arrises from interference between different superexchange pathways. This demonstrates that when two (or more) orbitals contribute to the localised spin superexchange can be significantly richer than in the textbook single orbital case. The hyper-honeycomb lattice contains two symmetry distinct sublattices of Cu atoms arranged in coupled chains. We show that one sublattice is strongly dimerized, the other forms isotropic antiferromagnetic chains. Integrating out the strongest (intradimer) exchange interactions leaves extremely weakly coupled Heisenberg chains.
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