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Book Antiplasmodial Compounds Geared with Multistage Potency from the Parasite Plasmodium falciparum: Inside Vitro along with Vivo Assessments and Pharmacokinetic Scientific studies.
In this paper we present a tunable filter using Ge2Sb2Se4Te1 (GSST) phase change material. The design principle of the filter is based on a metal-insulator-metal (MIM) cavity operating in the reflection mode. This is intended for night vision applications that utilize 850nm as the illumination source. The filter allows us to selectively reject the 850nm band in one state. This is illustrated through several daytime and nighttime imaging applications.A smart digital micromirror device (DMD) was employed to realize the on-chip scanning in versatile hyperspectral imaging (HSI) systems in our previous research. However, the rotation manner around the diagonal of the DMD makes the imaging subsystem and the spectral dispersion subsystem unable to be in the same horizontal surface. This leads to the difficulty in designing the opto-mechanical structures, system assembly and adjustment of the light path to a certain extent. On the other hand, the HSI system also needs a larger space to accommodate the two subsystems simultaneously since either of them has to incline against the horizontal surface. Moreover, there exists the interference of the reflected light between the adjacent micromirrors during the scanning process performed by the DMD, causing the loss of optical information about the object. Here, a novel linear micromirror array (MMA) based on the microelectromechanical system process that rotates around one lateral axis of the micromirror is developed, which is helpful to simplify the optical system of HSI and obtain more optical information about the detected target. The MMA has 32 independent linear micromirrors across an aperture of 5mm×6.5mm, under which there are dimple structures and a common bottom electrode. Finally, the MMA with a 98.6% filling factor is successfully fabricated by employing the bulk micromachining process. The experimental results show that the maximum rotational angle is 5.1° at a direct current driving voltage of 30 V. The proposed micromirror array is promising to replace the DMD and shows potential as a spatial light modulator in the fields of hyperspectral imaging, optical communication, and so on.This paper presents the optical design of a digitally switchable multi-focal microlens array which can be used to extend the depth of field in integral imaging systems. The proposed switchable multi-focal microlens array consists of a customized freeform multi-focal microlens array (MLA) and a programmable spatial light modulator. By switching among the different optical powers of the switchable multi-focal MLA, an integral imaging system can render or capture a 3D scene at a large depth range around several central depth planes. We demonstrate the design considerations for a dual-focal microlens array with a primary and secondary focal lengths of 4mm and 4.06mm, respectively. We further validated the design by providing both interferometric measurements of the surface profiles and image contrast and resolution tests of a manufactured MLA prototype.Most reported metasurfaces operate in single propagation direction mode (either transmissive mode or reflective mode), which hamper practical application. Here, we proposed a bi-directional operation coding metasurface based on a phase change material of a vanadium dioxide (VO2) assisted metasurface. It can realize a dynamically invertible switch between the transmissive mode or reflective mode in the terahertz regime by changing the external ambient temperature. The proposed structure consists of a silicon column, polyimide dielectric substrate layer, and VO2 film bottom layer. When VO2 is in dielectric state, the designed metasurface possesses the functions of transmission beam splitting and deflection and generates a transmission vortex beam. When VO2 is in metallic state, the proposed metasurface exhibits many functions such as reflection beam splitting, deflection, radar scattering surface (RCS) reduction and reflection vortex beam generation. The proposed metasurface can solve transmissive and reflective bi-direction terahertz encoding regulation. This scheme provides a new method to realize multi-function terahertz devices.We develop a simple and effective control method for accurate control of deformable mirrors (DMs). Orforglipron manufacturer For a desired DM surface profile and using batches of observed surface profile data, the proposed method adaptively determines both a DM model (influence matrix) and control actions that produce the desired surface profile with good accuracy. In the first iteration, the developed method estimates a DM influence matrix by solving a multivariable least-squares problem. This matrix is then used to compute the control actions by solving a constrained least-squares problem. Then, the computed actions are randomly perturbed and applied to the DM to generate a new batch of surface profile data. The new data batch is used to estimate a new influence matrix that is then used to re-compute control actions. This procedure is repeated until convergence is achieved. The method is experimentally tested on a Boston Micromachines DM with 140 micro-electronic-mechanical-system actuators. Our experimental results show that the developed control approach can achieve accurate correction despite significant DM nonlinearities. Using only a few control iterations, the developed method is able to produce a surface profile root-mean-square error that varies from 5 - 30 [nm] for most of the tested Zernike wave-front modes without using direct feedback control. These results can additionally be improved by using larger data batches and more iterations or by combining the developed approach with feedback control. Finally, as we experimentally demonstrate, the developed method can be used to estimate a DM model that can effectively be used for a single-step open-loop DM control.Fiber couplers usually take a lot of space on photonic integrated circuits due to the large mode-size mismatch between the waveguide and fiber, especially when a fiber with larger core is utilized, such as a few-mode fiber. We demonstrate experimentally that such challenge can be overcome by an ultra-compact mode-size converter with a footprint of only 10 µm. Our device expands TE0 and TE1 waveguide modes simultaneously from a 1-µm wide strip waveguide to an 18-µm wide slab on a 220-nm thick silicon-on-insulator, with calculated losses of 0.75 dB and 0.68 dB, respectively. The fabricated device has a measured insertion loss of 1.02 dB for TE0 mode and 1.59 dB for TE1 mode. By connecting the ultra-compact converter with diffraction grating couplers, higher-order modes in a few-mode fiber can be generated with a compact footprint on-chip.Continuous monitoring of voltages ranging from tens to hundreds of kV over environmental conditions, such as temperature, is of great interest in power grid applications. This is typically done via instrument transformers. These transformers, although accurate and robust to environmental conditions, are bulky and expensive, limiting their use in microgrids and distributed sensing applications. Here, we present a millimeter-sized optical voltage sensor based on piezoelectric aluminum nitride (AlN) thin film for continuous measurements of AC voltages less then 350kVrms (via capacitive division) that avoids the drawbacks of existing voltage-sensing transformers. This sensor operated with 110μW incident optical power from a low-cost LED achieved a resolution of 170mVrms in a 5kHz bandwidth, 0.04% second harmonic distortion, and a gain deviation of +/-0.2% over the temperature range of ~20-60°C. The sensor has a breakdown voltage of 100V, and its lifetime can meet or exceed that of instrument transformers when operated at voltages less then 70kVrms with capacitive division. We believe that our sensor has the potential to reduce the cost of grid monitoring, providing a path towards more distributed sensing and control of the grid.We design and experimentally demonstrate a simple, single-shot method for the generation of arbitrary composite vortex (CV) beams using hybrid binary fork gratings (hBFG). These gratings were computationally generated by removing the central region around the fork-dislocation of azimuthal charge ℓ1 and substituting it with a BFG of a different charge ℓ2. The geometrical parameters of hBFGs were optimized for the efficient generation of CV beams. The method was further extended to the generation of CV beams consisting of three different ℓ and of higher radial charges p. This simple generation method may be useful to generate complex beam shapes with engineered phase fronts without complicated interferometry based techniques.Beam tracking-and-steering is crucial for the operation of high-speed, narrow beam, optical wireless communication (OWC) systems. Using a system based on two sets of low-cost cameras for continuous beam tracking and a set of mirrors for steering, we demonstrate here a high-capacity (>1Tbit/s) ten-channel wavelength-division multiplexed (WDM) OWC system based on discrete multitone transmission. The results, which are achieved over a 3.5-m perpendicular distance and across a lateral coverage up to 1.8 m, constitute to the best of our knowledge, the highest aggregate OWC capacity at this coverage.This study presents a partially coherent illumination based (PCI-based) SIM apparatus for dual-modality (phase and fluorescent) microscopic imaging. The partially coherent illumination (PCI) is generated by placing a rotating diffuser on a monochromatic laser beam, which suppresses speckle noise in the dual-modality images and endows the apparatus with sound sectioning capability. With this system, label-free quantitative phase and super-resolved/sectioned fluorescent images can be obtained for the same sample. We have demonstrated the superiority of the system in phase imaging of transparent cells with high endogenous contrast and in a quantitative manner. In the meantime, we have also demonstrated fluorescent imaging of fluorescent beads, rat tail crosscut, wheat anther, and hibiscus pollen with super-resolution and optical sectioning. We envisage that the proposed method can be applied to many fields, including but not limited to biomedical, industrial, chemistry fields.We propose analysis methods for mirror bonding. The functional relationship between the shrinkage of the adhesive layer and the shape accuracy of the mirror is established numerically. By designing the structural form of the optical mounting and setting an appropriate stiffness ratio between the mirror and bonding position of the optical mounting, the theoretical surface shape accuracy change can be determined. Accordingly, the mirror is bonded, and the surface shape accuracy of the mirror after bonding is found to be 0.020λ. This approach is useful in mirror design applications that require rapid preparation and accuracy control.Aiming to determine the scattered estimation of complex and electrically large targets coated with the uniaxial electric anisotropic medium (UEAM) from a distributed excitation source, the demanding study is simplified by constructing the physical optics (PO) architecture which consists of three aspects, the discrete facet modeling, the tangent plane approximation, and the scattering of an infinite PEC plate coated with the UEAM based on point-source excitation, including the electric and magnetic dipole. We depict the outer surface of an electrically large scatterer as the constitution of countless tiny triangular facets. From the tangent plane approximation employed in the PO method, the scattered fields of any discretized facet induced by the equivalent electromagnetic currents (EECs) can be further evaluated as the surface fields of an infinite UEAM-coated PEC slab. Therefore, the rigorous solution of the dyadic Green's function (DGFs) for an infinite anisotropic-medium-coated PEC plate under point-source incidence is computed first.
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