Notes

Concentrating on Fatty Acid Synthase Modulates Metabolic Pathways and Stops Cholangiocarcinoma Mobile Further advancement.
Conversely, residues with high aromaticity and hydrophobicity (i.e., silver maple) caused a decrease in labile inorganic P and increase in microbial P under the same soil organic CP, indicating the dominance of P immobilization. At a soil organic CP of 300, both sugar maple and silver maple promoted P immobilization. Mineralization rates were of lesser magnitude in the soils amended with silver maple, which interestingly contained the largest proportions of recalcitrant C and the highest ratios of aromaticity and hydrophobicity.
Diabetes is a chronic and complex disease determined by environmental and genetic factors. This study aimed to investigate the association between polycyclic aromatic hydrocarbons (PAHs) exposure and fasting blood glucose levels and telomere length among coke-oven plant workers, to explore potential role of telomere length (TL) in the association between PAHs exposure and abnormal glucose level.

The cross-sectional survey was conducted in 2017. The high-performance liquid chromatography mass spectrometry (HPLC-MS) was used to detect 11 urine biomarkers of PAHs exposure. TL was measured using the Real-time quantitative polymerase chain reaction (RT-qPCR) method. Logistic regression model, the modified Poisson regression models, and mediation analysis were used to evaluate the associations between PAHs exposure, TL, and abnormal glucose.

The results showed that the urinary 1-hydroxypyrene (1-PYR) was positively related to abnormal glucose in a dose-dependent manner (P
=0.007), the prevalence ratio of abnormal glucose was 8% (95% CI 1.01-1.16) higher in 3rd tertile of urinary 1-PYR levels. Urinary 1-PYR in the 2nd tertile and 3rd tertile were associated with a 53% (OR=0.47, 95% CI 0.28-0.79) and 59% (OR=0.41, 95% CI 0.23-0.76) higher risk of shortening TL. And there was a negatively association between 1-PYR and TL in a dose-dependent manner (P
=0.045). We observed that the association between 1-PYR and abnormal glucose was more significantly positive among participants with median TL level (P
=0.006). In addition, mediation analysis showed the TL could explain 11.7% of the effect of abnormal glucose related to PAHs exposure.

Our findings suggested the effect of abnormal glucose related to PAHs exposure was mediated by telomere length in coke oven plant workers.
Our findings suggested the effect of abnormal glucose related to PAHs exposure was mediated by telomere length in coke oven plant workers.Saccharina japonica is an ecologically and economically important seaweed that is dominant in the rocky shores of cold-temperate regions, forms the major component of productive beds, and affects marine environments. S. japonica exhibits a high photosynthetic efficiency in natural seawater with low dissolved CO2 concentration, thus suggesting the presence of its carbon-concentrating mechanism (CCM). However, the genes, proteins, and pathways involved in the CCM of S. japonica have not been fully identified and characterized. Carbonic anhydrase (CA) is a crucial component of CCM in macroalgae. In this study, the cloning, characterization, and subcellular localization of a specific CA were described. Multisequence alignment and phylogenetic analysis indicated that this CA belonged to the gamma (Sjγ-CA) class. This enzyme has a full-length cDAN of 1370 bp, encodes a protein with 246 amino acids (aa; ca. 25.7 kDa), and contains the mitochondrial transit peptide of 16 aa and LbH_gama_CA_like domain of 159 aa that defined the γ-CA region. The Sjγ-CA was successfully expressed in E. coli BL21 and purified as an active recombinant CA. Immunogold electron microscopy and fluorescence localization illustrated that this enzyme is localized in the mitochondria, and its transcription level is up-regulated by low CO2 concentration. These findings showed that Sjγ-CA is a possible component of the CCM in S. japonica. This work is the first to report about the mtCA of macroalgae and provides a basis for further analysis on seaweed CCM.The continuous production of plant wastes and heavy metal pollution of waters have become widespread unavoidable challenges. Reutilization of plant wastes to treat toxic metal-contaminated water is an eco-friendly way to simultaneously solve these problems. Herein, three cake-like biosorbents were synthesized from tea waste, trimmed lawn grass and Nephrolepis cordifolia leaves through a one-step xanthation modification method combined with lyophilization, respectively. The plant species affected the appearance, structure and mechanical strength of the biosorbents due to the different contents of hydrocarbons and inorganic substances, which influenced the gel-like degree and thus the ability of the particles to pack between water molecules. The maximum adsorption capacities of the modified materials for Pb(II), Cu(II) and Cd(II) were 247.20, 85.80 and 265.31 mg/g, respectively, far higher than those of the original wastes, and the adsorption was selective. These results were mainly attributed to newly introduced -(CS)-S-Na groups, which triggered ion exchange, complexation and microprecipitation between heavy metal ions and functional groups. As-prepared biosorbents owned an excellent regenerability, which contributed to recovery heavy metals. The physicochemical properties and adsorption performances of the modified materials indicated that xanthation is a universal modification method suited to different plant biomasses with great potential to purify heavy metal-contaminated water. These biosorbents with excellent separability and regenerability might be promising for continuous-flow sewage treatment.The inexorable industrialization and modern agricultural practices to meet the needs of the increasing population have polluted the environment with toxic heavy metals such as Cr(VI), Cu2+, Cd2+, Pb2+, and Zn2+. Among the hazardous heavy metal(loid)s contamination in agricultural soil, water, and air, hexavalent chromium [Cr(VI)] is the most virulent carcinogen. The metallurgic industries, tanneries, paint manufacturing, petroleum refineries are among various such human activities that discharge Cr(VI) into the environment. Various methods have been employed to reduce the concentration of Cr(VI) contamination with nano and bioremediation being the recent advancement to achieve recovery at low cost and higher efficiency. Bioremediation is the process of using biological sources such as plant extracts, microorganisms, and algae to reduce the heavy metals while the nano-remediation uses nanoparticles to adsorb heavy metals. In this review, we discuss the various activities that liberate Cr(VI). We then discuss the various conventional, nano-remediation, and bioremediation methods to keep Cr(VI) concentration in check and further discuss their efficiencies. We also discuss the mechanism of nano-remediation techniques for better insight into the process.The inactivation of bacteriophage MS2 by sodium hypochlorite was investigated to understand the effect of solution chemistry on the disinfection efficacy in the presence of particles. Kaolinite and Microcystis aeruginosa (M. aeruginosa) were used as the models of inorganic and organic particles to simulate high turbidity and algal cells, respectively, in drinking water sources. In both particle-containing solutions, lower pH, the presence of cations (di-valent Ca2+) and natural organic matters (NOM) were regarded as the main factors to influence the aggregation and inactivation of MS2. The results showed that MS2 aggregated in all solutions at pH 3.0, protecting the inner viruses. At pH 7.0, the presence of Na+ cations (0-200 mmol/L) did not affect the inactivation efficacy of MS2, which always followed the order of particles-free ≈ kaolinite > M. aeruginosa. The inactivation efficacy of MS2 in the presence of Ca2+ cations followed the order of kaolinite > particles-free > M. aeruginosa at 0-50 mmol/L Ca2+ cations, while the inactivation efficacy remained almost constant in the range of 100-200 mmol/L Ca2+ cations. By contrast, kaolinite offered not enough protection to adsorbed MS2, but MS2 aggregation decreased disinfection efficacy at a high concentration of Ca2+ cations. Moreover, the presence of humic acid as NOM decreased the inactivation of MS2 more significantly than M. aeruginosa due to the more consumption of free chlorine from humic acids. Therefore, the co-existence of NOM and di-valent Ca2+ cations are potential challenges for the inactivation of viruses by sodium hypochlorite in safe drinking water.Studies based on questionnaires suggested that maternal exposure to pesticides increases the risk for orofacial clefts (OFCs). However, whether organochlorine pesticides (OCPs) exposure in vivo affects the occurrence of OFCs remains unclear. The aims of this study are to investigate the association of OCP exposure with the risk of OFCs by examining the concentrations of OCPs in human umbilical cords, and investigate the potential dietary sources of OCPs in umbilical cord tissues. A case-control study consisting of 89 OFC cases and 129 nonmalformed controls with available tissues of umbilical cord was conducted. Concentrations of twenty specific OCPs were determined in the umbilical cord by gas chromatograph-mass spectrometry, and seven OCPs with detection rate larger than 50% were included in analyses. The individual effect and joint effect of multiple OCPs in umbilical cords on the risk for OFCs were investigated using multivariate logistic models and Bayesian Kernel Machine Regression (BKMR). No difference was found in the median levels of ΣOCPs between cases (1.04 ng/g) and controls (1.03 ng/g). No significant associations were observed between levels of OCPs in umbilical cords and risk for OFCs in either multivariate logistic models or BKMR models. Maternal consumptions of beans or bean products were positively correlated with levels of β-hexachlorocyclohexane, heptachlor epoxide, p,p'-DDE, and ∑OCPs in umbilical cord, respectively. In conclusion, we didn't find the association between in utero exposure to OCPs and the risk for OFCs. selleck Maternal consumptions of beans or bean products may be a source of OCPs exposure.Radioactive iodine (129I) is of great concern owing to its high mobility in the environment and long-term radiotoxicity. However, there is a lack of effective techniques for removing iodate (IO3-) from aqueous solution. This study aims to develop a new technique for removing radioactive iodate from contaminated solution by using barite (BaSO4). We examined the coprecipitation mechanism of iodate by barite at the molecular level to determine the optimum conditions for iodate removal. Results showed that iodate was effectively removed from the aqueous solution by coprecipitation even in the presence of competitive anions. Based on comparison of our method with previous techniques, the iodate removal efficiency by barite was determined to be about two orders of magnitude greater than that by hydrotalcite-like layered double hydroxide at 10 mmol L-1 Cl-. Extended X-ray absorption fine structure analysis indicated that the incorporated iodate was strongly bound to the crystal lattice of barite by substituting the sulfate site in the structure when the iodine concentration was low. The charge compensation problem from the IO3- substitution in the SO42- site was achieved by the substitution of Na+-IO3- pairs at the nearest Ba2+ site. Given the high removal efficiency and strong binding of iodate to barite, coprecipitation with barite is a promising tool for removing radioactive iodate from various aqueous solutions contaminated with iodate.
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