Notes

PLA2R as well as membranous nephropathy: A new 3 year potential Aussie review.
S. adults (7.5 million) became new gun owners from 1 January 2019 to 26 April 2021. Most (5.4 million) had lived in homes without guns, collectively exposing, in addition to themselves, over 11 million persons to household firearms, including more than 5 million children. Approximately half of all new gun owners were female (50% in 2019 and 47% in 2020 to 2021), 20% were Black (21% in 2019 and in 2020-2021), and 20% were Hispanic (20% in 2019 and 19% in 2020-2021). By contrast, other recent purchasers who were not new gun owners were predominantly male (70%) and White (74%), as were gun owners overall (63% male, 73% White).

Retrospective assessment of when respondents purchased firearms. National estimates about new gun owners were based on 447 respondents.

Efforts to reduce firearm injury should consider the recent acceleration in firearm purchasing and the characteristics of new gun owners.

The Joyce Foundation.
The Joyce Foundation.
In a randomized, placebo-controlled, clinical trial, bamlanivimab, a SARS-CoV-2-neutralizing monoclonal antibody, given in combination with remdesivir, did not improve outcomes among hospitalized patients with COVID-19 based on an early futility assessment.

To evaluate the a priori hypothesis that bamlanivimab has greater benefit in patients without detectable levels of endogenous neutralizing antibody (nAb) at study entry than in those with antibodies, especially if viral levels are high.

Randomized, placebo-controlled trial. (ClinicalTrials.gov NCT04501978).

Multicenter trial.

Hospitalized patients with COVID-19 without end-organ failure.

Bamlanivimab (7000 mg) or placebo.

Antibody, antigen, and viral RNA levels were centrally measured on stored specimens collected at baseline. Patients were followed for 90 days for sustained recovery (defined as discharge to home and remaining home for 14 consecutive days) and a composite safety outcome (death, serious adverse events, organ failure, or seriouse without and 1.79 (CI, 0.92 to 3.48) for those with nAbs.

Subgroup analysis of a trial prematurely stopped because of futility; small sample size; multiple subgroups analyzed.

Efficacy and safety of bamlanivimab may differ depending on whether an endogenous nAb response has been mounted. The limited sample size of the study does not allow firm conclusions based on these findings, and further independent trials are required that assess other types of passive immune therapies in the same patient setting.

U.S. government Operation Warp Speed and National Institute of Allergy and Infectious Diseases.
U.S. government Operation Warp Speed and National Institute of Allergy and Infectious Diseases.The quality and impact of the articles we publish in Circulation depend critically on the contributions and efforts of our extended team of peer reviewers, comprising hundreds of colleagues around the world. Although we received reliably outstanding reviews of all of the articles we submit for peer review, and we are grateful to every person who has contributed to Circulation in this way, a few reviewers have risen to the top, and we recognize them here. Please find our list of the Circulation Top Reviewers for 2021. This list is based on objective criteria of the quality of reviews provided, total number of papers reviewed, proportion of invitations accepted, and timeliness of review submissions. Many thanks and congratulations to all.Criterion B of the alternative model of personality disorder in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), outlines maladaptive trait dimensions that characterize personality disorders. Emerging evidence from bifactor confirmatory factor analyses suggest these traits are related at a higher order level by a general factor of personality disorder (g-PD). Further, emerging evidence points to traits most closely related to borderline personality disorder as underpinnings of g-PD. Further investigation is required to better understand the shared basis of personality disorder, with attention to the reliability and validity of g-PD. Gossypol The g-PD theory was examined in a clinical (n = 242), and community sample (n = 252) of adults, using a brief form of the Personality Inventory for DSM-5 (PID-5). Structural analyses supported a correlated 6-factor model and a bifactor solution, validating the g-PD structure. Reliability indices supported the unidimensionality, reliability, and replicability of the g-PD factor. The strongest loading and most unidimensional items on the g-PD factors were from the Negative Affectivity and Disinhibition trait domains, partially replicating the trait profile of borderline personality disorder traits. In validity analyses, the nomological network of the general and specific factors were examined. g-PD was more strongly correlated with internalizing measures and impairment than specific factors, but specific factors were more strongly correlated with thought disorder and externalizing measures than g-PD. Our results support the nature and reliability of a general factor characterized by Negative Affectivity and Disinhibition unifying personality disorder traits in a brief form of the PID-5. Implications for the alternative model of personality disorder, PID-5, and g-PD theory are discussed. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Methods for studying therapeutic alliance have primarily examined the impact of the early alliance on outcomes. This does not allow for an understanding of the contributions of client, therapist, and dyadic factors to the alliance. Also, the alliance may change over time, highlighting the need for longitudinal methods. Efforts have been made to develop approaches that decompose the contributing factors and their impact on outcomes, but these findings may not apply to clients with borderline personality disorder (BPD). Our study extends previous research by replicating Baldwin et al.'s (2007) approach to disentangling therapist versus client-therapist dyad effects while using a time-varying framework. Participants (n = 156) were individuals diagnosed with BPD randomized to 1 year of dialectical behavior therapy or general psychiatric management. Outcomes were general psychiatric severity and interpersonal functioning measured at baseline and every 4 months. Client-rated alliance was measured at these time points. Early alliance predicted interpersonal functioning (p = .0132) with a significant contribution from clients (p = .0248) but not therapists (p = .2854). In the time-varying analysis, client contribution to the alliance was significant (p = .0022). For general psychiatric severity, client contributions to the alliance were significant (p less then .0001) but not therapist contributions (p = .6779). Client contribution to the alliance was significant (p = .0168) in the time-varying model. Results suggest that in a BPD sample, time-varying alliance is a better predictor of rate of change in outcomes compared with the alliance measured at a single time point. In contrast to other studies, client, not therapist, contributions to alliance were significant in predicting outcomes. (PsycInfo Database Record (c) 2021 APA, all rights reserved).When we face danger or stress, the presence of others can provide a powerful signal of safety and support. However, despite a large literature on group living benefits in animals, few studies have been conducted on how group size alters subjective emotional responses and threat perception in humans. We conducted 5 experiments (N = 3,652) to investigate whether the presence of others decreases fear in response to threat under a variety of conditions. In Studies 1, 2 and 3, we experimentally manipulated group size in hypothetical and real-world situations and found that fear responses decreased as group size increased. In Studies 4 and 5 we again used a combination of hypothetical and real-world decisions to test whether increased anxiety in response to a potential threat would lead participants to choose larger groups for themselves. Participants consistently chose larger groups when threat and anxiety were high. Overall, our findings show that group size provides a salient signal of protection and safety in humans. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Individuals with social anxiety are sensitive to social hierarchies and tend to compare themselves unfavorably with others, perceiving themselves as inferior or lower in social rank. The current study explores patterns of change in these negative perceptions, and their associated emotional outcomes, in an online social context. Undergraduate students (N = 291) browsed the profiles of eight Instagram influencers and completed a measure of social comparison after viewing each profile, yielding multiple ratings of their own perceived social rank. Participants completed measures of affect and state self-esteem before and after the profile browsing task. Higher social anxiety predicted lower, and greater declines in, social rank self-perceptions during browsing. Higher social anxiety also predicted greater decreases in positive affect, increases in negative affect, and decreases in state self-esteem from the beginning to the end of the browsing task. Low baseline rank perceptions contributed to change in all three emotional variables. Decreases in rank perceptions contributed further to decreases in positive affect and appearance-related self-esteem. This study elaborates on cognitive-evolutionary theory, suggesting that the inferiority self-perceptions of socially anxious individuals translate to online social contexts, may be strengthened with increased exposure to such contexts, and may have a detrimental emotional impact. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Previous research has not led to any agreement as to the normative trajectory of relationship satisfaction. In this systematic review and meta-analysis, we summarize the available evidence on development of relationship satisfaction, as a function of age and relationship duration. Data came from 165 independent samples including 165,039 participants. In the analyses, we examined cross-sectional information on mean level, that is, the percent-of-maximum-possible (POMP) score at the first assessment, and longitudinal information on mean change (i.e., change in POMP scores per year). The mean age associated with effect sizes ranged from 20 to 76 years and the mean relationship duration from 3 months to 46 years. Results on mean levels indicated that relationship satisfaction decreased from age 20 to 40, reached a low point at age 40, then increased until age 65, and plateaued in late adulthood. As regards the metric of relationship duration, relationship satisfaction decreased during the first 10 years of the relationship, reached a low point at 10 years, increased until 20 years, and then decreased again. Results on mean change indicated that relationship satisfaction decreased within a given relationship, with the largest declines in young adulthood and in the first years of a relationship. Moderator analyses suggested that presence of children and measure of relationship satisfaction explained variance in the mean level. Except for these two moderators, the pattern of findings held across characteristics such as birth cohort, sample type, country, ethnicity, gender, household shared with partner, marital status, relationship transitions, and dyadic data. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
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