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Chitosan nanoparticles like a guaranteeing device inside nanomedicine along with specific emphasis on oncological therapy.
To determine the structure and mechanisms of interaction of asthenic disorders with negative and positive psychopathological symptoms in hypochondriac schizophrenia.

The study included male and female patients, aged 17-69 years, with a diagnosis of hypochondriac schizophrenia (F20.80 according to ICD-10) and asthenia symptoms. Irinotecan solubility dmso The main research method was clinical, which was supplemented by pathopsychological examination and the use of psychometric scales (PANSS, SANS, MFI-20,VAS asthenia).

Asthenia in case of hypochondriac schizophrenia (schizoasthenia) integrates two unrelated phenomena «weakness» and «exhaustion» (intolerance to stress), and also acts within the framework of three psychopathological syndromes neurotic, senestopathic/hypochondriac and overvalued hypochondria. Asthenia with hypochondriac schizophrenia is a predictor of an unfavorable social and clinical prognosis. Integrating into the structure of the clinical manifestations of hypochondriac schizophrenia, asthenia forms close relationhrenia.
The purpose of this study was to assess the relationship between power output and relative power output at the functional threshold power, ventilatory threshold and respiratory compensation point in road cyclists.

Forty-six road cyclists (age 38 ± 9 years; height 177 ± 9 cm; body mass 71.4 ± 8.6 kg; body mass index 22.7 ± 2.2 kg·m-1; fat mass 7.8 ± 4%, VO2max 61.1 ± 9.1 ml·min-1·kg-1) performed a graded exercise test in which power output and relative power output at the ventilatory landmarks were identified. Functional threshold power was established as 95% of the power output during a 20-minute test.

Power output and relative power output at the functional threshold power were higher than at the ventilatory threshold (p < 0.001). There were very large to near perfect correlations for power output (95% CI for r from 0.71 to 0.9) and relative power output (95% CI for r from 0.79 to 0.93) at the functional threshold power and respiratory compensation point. Mean bias in power ouput and relative power output measured at RCP compared with FTP was not significant (mean bias 95% CI from -7 to 10 W and - 0.1 to 0.1 W/kg, respectively).

Power output and relative power output at the functional threshold power are higher than at the ventilatory threshold. Power output and relative power output at the functional threshold power and respiratory compensation point are strongly related, but caution is required when using both concepts indistinctly.
Power output and relative power output at the functional threshold power are higher than at the ventilatory threshold. Power output and relative power output at the functional threshold power and respiratory compensation point are strongly related, but caution is required when using both concepts indistinctly.
The aim was to evaluate the distribution of ACE-I/D polymorphisms on Brazilian football players performance in aerobic capacity, strength, and speed tests.

The participants in this study were 212 Brazilian first division male football players genotyped in DD, ID. or II. Genotyping of DNA from leucocytes was performed using polymerase chain reaction and restriction fragment length polymorphism methods. We evaluated speed using a 30-m sprint test with speed measured at 10 m (V10), 20 m (V20), and 30 m (V30); muscular strength using counter-movement-jump and squat jump tests; and aerobic endurance using the Yo-Yo endurance test. The athletes were ranked in ascending order according to their performance in each test and divided into quartiles first quartile (0-25%, Weak), second (25-50%, Normal), third (50-75%, Good), and fourth (75-100%, Excellent); these were clustered according to genotype frequency.

We identified significant differences in the V20 test values and in the aerobic capacity test. Higher frequencies of the ACE-DD genotype were observed in the Excellent performance group in the V20. In the aerobic capacity test, higher frequencies of the ACE-II genotype were observed in Excellent and Good performance groups.

Players with higher performance in anaerobic and aerobic tests are ACE-DD and ACE-II genotypes, respectively.
Players with higher performance in anaerobic and aerobic tests are ACE-DD and ACE-II genotypes, respectively.
This study aimed to evaluate the relationship between physical activity habits, physical performance and cognitive capacity in older adults' population of Italy and Slovenia.

Anthropometric characteristics and body composition bioelectrical impedance analysis (BIA) were evaluated in 892 older adults (60-80 y). Aerobic capacity was measured using the 2km walking test and handgrip and flexibility tests were performed. Physical activity habits and cognitive functions were evaluated by the Global-Physical-Activity-Questionnaires (GPAQ) and by Montreal-Cognitive-Assessment (MoCA) questionnaires, respectively.

GPAQ scores were associated with lower BMI (r=-0.096; p=0.005), lower percentage of fat-mass (r=-0.138; p=0.001), better results in the 2km-walk test (r=-0.175; p=0.001) and a higher percentage of fat-free mass (r=0.138; p=0.001). We also evaluated that, a higher MoCA score correlates with age (r=-0.208; p=0.001), 2km-walk test (r=-0.166; p=0.001), waist-hip ratio (r=-0.200; p=0.001), resting heart-rate (r=-0.087; p=0.025) and heart-rate at the end of 2km-walk test (r=0.189; p=0.001).

Older adults with a higher level of daily physical activity showed reduction in fat mass and BMI, and higher aerobic fitness; these characteristics have a protection effect on cognitive function.
Older adults with a higher level of daily physical activity showed reduction in fat mass and BMI, and higher aerobic fitness; these characteristics have a protection effect on cognitive function.
Long-term adherence to sublingual immunotherapy (SLIT) results very poor in real-life studies. Effective actions are needed. Key point of any policy aimed to overcoming non-cost related barriers to medication long-term adherence is to actively support patients' needs and preferences starting from shared decisions making.
To explore SLIT related viewpoints, needs and preferences of a homogeneous group of patients. To assess their priority order and to what extent each of them could affect SLIT adherence. To find a rational basis for a proactive action-plan to support patients' needs and preferences and assess results on SLIT long-term adherence.
Preferences and viewpoint of patients in treatment-related decisions and their health-related needs have been explored by structured, direct interview of 65 adult patient. The activities of the hospital outpatient clinic were rearranged to support needs and requests shared by all patients, and to allow tailored interventions integrating them into routine practice.
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