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Idiopathic Interstitial Pneumonias: An assessment of the Past and Emerging Treatments.
In addition, inhibition of PARP-1 expression exacerbated cell damage and cell cycle arrest when DNA damage was low, but attenuated cell damage and even cell cycle arrest when DNA damage was severe. These findings in this study indicate that Cd causes DNA damage in NRK-52E cells, leading to cell cycle arrest at different phases depending on the degree of DNA damage. Moreover, PARP-1 plays an important role in mediating this effect, when DNA damage is low, it functions in DNA repair, however, when DNA damage is severe, it aggravates cell damage and induces cell death. Biochar has a wide range of feedstocks, and different feedstocks often resulted in different properties, such as element distribution and heavy metal immobilization performance. In this work, batch experiments were conducted to assess the effectiveness of biochar pyrolyzed from kitchen waste (KWB), corn straw (CSB), and peanut hulls (PHB) on immobilization of Cd and Pb in contaminated soil by planting swamp cabbage (Ipomoea aquatica Forsk.) with a combination of toxicological and physiological tests. The results showed that biochar could all enhance the soil pH, and reduce extractable Pb and Cd in soil by 22.61%-71.01% (KWB), 18.54%-64.35% (CSB), and 3.28%-60.25% (PHB), respectively. The biochar led to a drop in Cd and Pb accumulation in roots, stems, and leaves by 45.43%-97.68%, 59.13%-96.64%, and 63.90%-99.28% at the dosage of 60.00 mg/kg, respectively. The root length and fresh weight of swamp cabbage were promoted, while superoxide dismutase (SOD) and peroxidase (POD) decreased after biochar treatment. The distribution of heavy metal fractions before and after biochar treatment indicated that biochar could transform Cd and Pb into a state of lower bioavailability, thus inhibiting Cd and Pb uptake by swamp cabbage. find more Biochar with different feedstocks could be ranked by the following order according to immobilization performance KWB > CSB > PHB. link2 Groundwater arsenic pollution causes millions of deaths worldwide. Long term natural and anthropogenic activities have increased arsenic levels in groundwater causing higher threats of arsenic exposure. Arsenic hyper-tolerant Firmicute Bacillus firmus L-148 was isolated from arsenic limiting Lonar lake soil, which tolerated more than 3 M arsenic and could oxidize 75 mM arsenite [As(III)] in 14 days. It oxidized As(III) in presence of heavy metals and had unusual pH optima at 9.2. B. firmus L-148 was studied at the biochemical, protein, genomic and transcript level for understanding its arsenic oxidizing machinery. The proteomic and transcript analysis exhibited the presence of ars and aio operon and supported the inducible nature of ars operon. Robust, hyper-tolerant, fast As(III) oxidizing, least nutrient requiring and multi-metal resistance qualities of the strain were used in microcosm studies for bioremediation. Artificial groundwater mimicking microcosm with 75 mM As(III) was developed. Modulation of carbon source, iron and multi metals affected growth and As(III) oxidation rate. The As(III) oxidation was recorded to be 77% in 15 days in presence of sodium acetate and Fe ions. This microcosm study can be explored for bioremediation of arsenic contaminated water and followed by precipitation using other methods. The intensive application of type-II pyrethroid worldwide in agricultural and residential practices potentially contributes to soil and water pollution, raising various concerns about environmental and public health. In the present study, robust fungus (strain PYR-P2) with high pyrethroids degradation potential was isolated from pesticide-contaminated soil. The strain was identified based on morphology and molecular characteristics, as Aspergillus sp. The screening of the transforming ability of strain PYR-P2 was evaluated in minimal salt media (MSM), where the fungus utilized up to 500 mg L-1 of pyrethroid mixture (cypermethrin (CYP), cyfluthrin (CYF), cyhalothrin (CYH)). With this in view, central composite design (CCD) with three independent variables (pH, temperature, and initial concentration) was employed to identify the optimal conditions for achieving maximum pyrethroid removal. Under optimal conditions, strain PYR-P2 was implemented for the bioaugmentation studies in natural and sterile soil (NS/SS) systems spiked with pyrethroid (single and mixture) at a concentration of 100 mg kg-1. The highest pyrethroid removal percentages were observed in fungally augmented NS, accompanied by a decrease in pyrethroid half-life (t1/2). Herein, the observed half-life (t1/2) of pyrethroids in the fungally augmented NS varied between 1.48 and 2.69 d, with equally good values recorded in SS as 1.65-3.10 d. Taken together, the mycoremediation study employing fungal (strain PYR-P2) augmentation under optimized conditions represents an efficient strategy to restore pyrethroid-contaminated soil. Mosses take up nitrogen (N) mainly from precipitation through their surfaces, which makes them competent bioindicators of N deposition. We found positive relationships between the total N concentration (mossN%) of common terrestrial moss species (feather mosses Pleurozium schreberi and Hylocomium splendens, and a group of Dicranum species) and different forms of N deposition in 11-16 coniferous forests with low N deposition load in Finland. The mosses were collected either inside (Dicranum group) or both inside and outside (feather mosses) the forests. Deposition was monitored in situ as bulk deposition (BD) and stand throughfall (TF) and detected for ammonium (NH4+-N), nitrate (NO3--N), dissolved organic N (DON), and total N (Ntot, kg ha-1yr-1). Ntot deposition was lower in TF than BD indicating that tree canopies absorbed N from deposition in N limited boreal stands. However, mossN% was higher inside than outside the forests. In regression equations, inorganic N in BD predicted best the mossN% in openings, while DON in TF explained most variation of mossN% in forests. An asymptotic form of mossN% vs. TF Ntot curves in forests and free NH4+-N accumulation in tissues in the southern plots suggested mosses were near the N saturation state already at the Ntot deposition level of 3-5 kg ha-1yr-1. N leachate from ground litterfall apparently also contributed the N supply of mosses. Our study yielded new information on the sensitivity of boreal mosses to low N deposition and their response to different N forms in canopy TF entering moss layer. The equations predicting the Ntot deposition with mossN% showed a good fit both in forest sites and openings, especially in case of P. schreberi. However, the open site mossN% is a preferable predictor of N deposition in monitoring studies to minimize the effect of tree canopies and N leachate from litterfall on the estimates. Present study screened the toxicological assessment of airborne particulate matter (PM), mechanistic investigation, relationship between the physicochemical characteristics and its associated toxic response. The average concentration of both PM10 and PM2.5 exceeded the Indian National Ambient Air Quality Standards. In present study, PM bound metals; Fe, Cu, Cr, Ni, Mn, Pb, Cd, Zn, Sr and Co have been taken into account with total metal concentration of 0.83 and 0.44 μg m-3 of PM10 and PM2.5 mass concentrations, respectively. link3 The contribution of redox active metals (Fe, Cu, Cr, Ni and Mn) in PM was more as compared to non-redox metals (Pb, Cd and Co) indicating significant risk to the exposed population as these metals possess the ability to produce reactive oxygen species (ROS) which are responsible for various diseases. The cytotoxicity profiles of PM samples determined by MTT assay on two different cell lines (A549 and PBMC) exhibited dose-dependent effects after 24 h exposure, but the consequences differ with respect to particle size and sampling periods. A significant decrease in cell viability with varying PM concentrations (20, 40, 60, 80 and 100 μg ml-1) with respect to control was found in both cell lines. Incubation of RBC suspension with PM samples caused pronounced disruption of RBC and thus exhibited substantial hemolytic behavior. PM samples showed a range of potency to produce reactive oxygen species (ROS). Almost all PM samples increased the level of pro-inflammatory mediator (Nitric oxide) when compared to corresponding unexposed controls suggesting the important role of reactive nitrogen species in induction of cellular toxicity. Sediment dissolved organic matter (DOM) was collected in November 2018 from Lake Dongping, China. The lake was divided into the entrance of the Dawen River, the open region of the lake, the tourism district and the macrophyte-dominated region based on principal component analysis (PCA) of 9 DOM-related parameters. Multispectroscopic tools were used to investigate the binding of zinc (Zn) with four kinds of DOM collected from the entrance of the Dawen River (EDOM), the open area of the lake (ODOM), the macrophyte-dominated area (mainly dominated by Potamogeton crispus L.) (PDOM) and the tourism district (TDOM). Three fluorescent components, the humic-like (components 1 and 3) and protein-like (component 2) components, were found by excitation-emission matrix spectra with parallel factor analysis. The EDOM, ODOM and TDOM were controlled by protein-like components, and the PDOM was controlled by humic-like components. Different components respond differently to Zn addition. The binding order of the tyrosine-like fraction > the tryptophan fraction > the humic-like fraction was identified by Synchronous fluorescence (SF) spectra and two-dimensional correlation spectroscopy (2D-COS). The fluorescence intensity of the protein-like component was suppressed, and the humic-like component was enhanced with the addition of Zn. The effective quenching constants (log K) of the protein-like component in PDOM were clearly higher than those in the EDOM, ODOM and TDOM, indicating higher metal binding potential in PDOM than in other kinds of DOM in Lake Dongping. The %Fmax (the amounts of each component measured as % of the total fluorescence maxima for the three components) of the humic-like components exhibited a gradual increase in all kinds of DOM with the addition of Zn, suggesting that the addition of Zn increased the humification of DOM. Electron-donating moieties (EDM) have recently been used to characterize the redox properties and treatability of dissolved organic matter during water and wastewater treatment. In this study, size exclusion chromatography followed by a derivatization-spectrometric method was developed to determine the molecular weight (MW) distribution of EDM in dissolved organic matter. The relationships between EDM concentration and chromophore content (indicated by UVA254), fluorophore content (indicated by fluorescence), and dissolved organic carbon (DOC) concentration were analyzed for different MW fractions. In general, natural organic matter (NOM) showed higher total EDM concentration and higher EDM average MW than effluent organic matter (EfOM). For NOM, fractions with MW between 1.8 k and 6.9 k Da accounted for most of the EDM (45.4%-48.6%), followed by the fractions with MW 1.8 k Da) and lower MW ( less then 1 k Da) preferentially resulted in benzoquinone formation and ring-cleavage, respectively.
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