Notes

Corrigendum: Scorpion Venom Prescribed analgesic Peptide, BmK AGAP Prevents Stemness and Epithelial-Mesenchymal Move by simply Down-Regulating PTX3 throughout Cancer of the breast.
Increased GLUT-1 expression has a consistent role in the malignant transformation of OED and aggressiveness of OSCC.
Increased GLUT-1 expression has a consistent role in the malignant transformation of OED and aggressiveness of OSCC.
Macrophages account for 30%-50% of the total inflammatory cell population of ''tumor microenvironment'' that plays an important role in cancer metastasis. M2 macrophages are designated as tumor-associated macrophages (TAMs). They are known to orchestrate all the stages of tumor progression. CD163 is TAMs-M2-specific marker.

The aim of the study was to evaluate the role of TAMs using CD163 in different histological grades of oral squamous cell carcinoma (OSCC).

Expression of CD 163 was investigated in 30 histopthologically diagnosed cases of OSCC.

Two sections of 4-μ thickness were stained with hematoxylin and eosin, CD163 (Cell Marque, USA). The expression of TAMs with CD163-positive cells was done by counting the number of macrophages in three high-power fields (×400), and the mean number of macrophages per HPF was evaluated.

The statistical analysis was performed using Statistical Software SPSS version 20.0.

CD163 TAMs score increasing in higher tumor, node, metastasis stages with significant positive correlation.

With higher histological grades, CD163 TAMs score increased. Thus, TAMs may be considered as an independent factor for determining the progression of the tumor. The immunotherapeutic approaches to control M2 TAM numbers could protect against progression to malignancy.
With higher histological grades, CD163 TAMs score increased. Thus, TAMs may be considered as an independent factor for determining the progression of the tumor. The immunotherapeutic approaches to control M2 TAM numbers could protect against progression to malignancy.
Cemento-osseous dysplasia (COD) is a distinct entity, which is confined to the tooth-bearing areas of the jaws or edentulous alveolar processes.

This study analyzes the demographic, clinical, radiographic and histopathological features of COD.

Archival data from 2013 to 2017 present in the Department of Oral Pathology were retrieved. Clinicopathological and radiological features of all the cases which had been previously diagnosed as COD were analyzed in detail.

In the present study, 10 cases of COD were analyzed (1 periapical, 6 florid and 3 focal). Equal sex predilection was observed. The mean age in females and males was 42.6 years (22-64 years) and 28.6 years (17-36 years), respectively. Bony expansion was seen frequently, but pain was not a common feature. Mandible was affected almost twice as frequently as maxilla and posterior region was affected more than anterior region. Most cases showed mixed radiopaque and radiolucent lesion (5/10) and peripheral radiolucent rim (9/10) on radiographic examtures is of paramount importance in the accurate diagnosis of COD.
Log odds of positive lymph nodes (LODDS) have been recently demonstrated as a very promising staging model and have outperformed AJCC pN, lymph node ratio (LNR) category in major cancers. Literature is scarce concerning the prognostic ability of LODDS in oral squamous cell carcinoma (OSCC) patients.

The present study was aimed to evaluate the importance of LODDS in predicting locoregional recurrence and overall survival (OS) in patients with OSCC compared to LNR.

The retrospective study was carried out on 194 patients with OSCC cases treated by surgery ± adjuvant therapy from 2008 to 2014 at our institution.

Demographical and clinicopathological details of study cases were recorded. LNR and LODDS were calculated and expressed as a percentage and mean ± standard deviation.

The OS analysis was done by the Kaplan-Meier curve followed by log-rank (mantel-cox) test. Univariate and multivariate survival analysis was done to analyze the prognostic ability of LNR% and LODDS after adjusting the clinicopathological parameters by the Cox proportional hazards model.

Patients with cut off values of LODDS >-1.2 and LNR% >4 had significantly lower mean OS (
≤ 0.001). Multivariate analysis indicated that only mean LODDS >-1.2 was significantly associated with poor OS. Although there was a correlation with locoregional recurrence, LODDS and LNR failed to be the independent predictors of locoregional recurrence.

LODDS was an independent reliable prognostic indicator for patients with OSCCs than conventional staging systems and LNR.
LODDS was an independent reliable prognostic indicator for patients with OSCCs than conventional staging systems and LNR.
The purpose of this study was to estimate hemoglobin (Hb) level, red cell indices (RCIs), serum iron level and Vitamin B12 level in patients with oral submucous fibrosis (OSMF) and to analyze the association of these parameters in different stages of OSMF.

This case-control study comprised of 65 individuals, with 40 OSMF patients and 25 controls. The OSMF patients were graded clinically according to the classification by Arakeri
. Fasting blood samples were collected from both groups for hematological evaluation.

The mean values and standard deviations were calculated by Chi-square test. Normality of various parameters was evaluated by Kolmogorov-Smirnov test. The independent
-test was used to compare more than two means simultaneously. Correlation analysis was done by Karl Pearson's correlation coefficient method.

The OSMF patients were in the age range of 21-67 years, with a mean age of 39.85 ± 10.42 years. The mean value of Hb of the control group was 14.24 ± 1.03 g/dL, whereas that of OSMF group was 11.18 ± 2.06 g/dL (
< 0.001). The mean value of the serum iron level of the control group was 119.67 ± 42.42 μg/dL, whereas that of the OSMF group was 45.04 ± 10.41 μg/dL (
< 0.001). The mean value of serum Vitamin B12 levels of the control group was 422.98 ± 112.57 μg/dL, whereas that of the OSMF group was 211.78 ± 45.17 μg/dL (
< 0.001). The RCIs including packed cell volume, mean corpuscular volume, mean corpuscular Hb (MCH) and MCH concentration were significantly reduced in OSMF cases. Iron deficiency was present in 38 patients among the study group and Vitamin B12 deficiency was present in 22 patients of the study group.

OSMF causes depletion of minerals and trace elements, and its replenishment is required for the healing of tissues and performing daily routine activities.
OSMF causes depletion of minerals and trace elements, and its replenishment is required for the healing of tissues and performing daily routine activities.Rushton bodies (RBs) are hyaline bodies found in epithelial lining of the odontogenic cysts that appear as peculiar, eosinophilic, straight or curved, irregular or rounded, polycyclic glassy structures occurring with variable frequency in the epithelial lining of odontogenic cysts. This article depicts the various shapes and amusing staining properties of RBs along with a brief cognizance about their much-debated origin.
Estimation of time since death is the preliminary step in any postmortem examination. Although there are various physiological methods to conclude the postmortem, interval histological changes can be applied to obtain precision. However, the utility of oral tissues for such an event is still evolving.

The present study was conducted to assess the efficacy of postmortem histological changes that occur in tongue to conclude the postmortem interval (PMI).

After obtaining institutional human ethical committee, tongue tissue was collected for during routine autopsy procedure. The study comprised twelve autopsied tongue tissues. The tissue specimens were subjected to routine laboratory tissue processing procedure and the histological changes were evaluated.

This is the first study of this kind in the scientific literature to explore the tongue tissue to estimate the PMI. There were definite changes in the epithelium and the connective tissue of the tongue, and these features were highly remarkable at various postmortem time intervals.
This is the first study of this kind in the scientific literature to explore the tongue tissue to estimate the PMI. There were definite changes in the epithelium and the connective tissue of the tongue, and these features were highly remarkable at various postmortem time intervals.Pleomorphic adenoma is the most common benign salivary gland tumor deriving its name from varied morphological patterns in histopathology. The presence of chondromyxoid stroma in histopathology is characteristic of pleomorphic adenoma. Cellular variants without characteristic chondromyxoid stroma are rare and often pose a diagnostic challenge. We report a case of pleomorphic adenoma involving minor salivary glands of the palate presenting with a predominantly cellular histopathology. Immunohistochemical workup was pivotal in the diagnosis of this challenging case.Mucormycosis is an emerging fungal infection which has exceptionally high mortality rates in immunocompromised patients and remains a life-threatening infection in uncontrolled diabetics. The reported cases in literature may be less in number due to its frequent misdiagnosis. Imaging techniques in the early stages are usually nondiagnostic and cytological smears are not very reliable, thus, the gold standard for definitive diagnosis remains with the histopathological examination. https://www.selleckchem.com/products/debio-0123.html A thorough understanding of the pathogenesis and host fungus interaction aids in the histopathological evaluation and clinical management. Despite of surgical and medical management, the overall mortality rate remains high in persistently immunocompromised individuals. We present a case report of a 58-year-old female patient with rhinomaxillary mucormycosis with a history of uncontrolled diabetes.Hidradenoma Papilliferum (HP) is a rare, benign, cutaneous adnexal tumor of middle-aged females arising mainly in the apocrine sweat glands of perianal and genital region. Initially, HP was considered to be an apocrine sweat gland tumor however recent research showed that it descends from the anogenital mammary-like glands, HP can be regarded theoretically as the cutaneous complement of mammary intraductal papilloma. Nongenital HP is an infrequent manifestation, ectopic forms of this entity have been defined with bulk of them occurring on the head and neck region (60%) and 85% of cases being 1.5 cm in the greatest diameter or lesser. Average age of patients with ectopic HP is 1-2 decades older than the age range of onset in patients with anogenital HP. Here, we present a 15-year-old adolescent female with an unusually large, ectopic occurrence of nodular HP on right cheek since 2 years.Cementoblastoma is a relatively uncommon, benign odontogenic mesenchymal tumor that is associated with and attached to the roots of teeth. It is considered to be the only true neoplasm of cemental origin. Its prevalence has been reported to vary from 0.69% to 8% of all odontogenic tumors. The tumor is frequently seen in the second and third decades of life and affects the molar and premolar regions of the mandible predominantly. We herein describe a case of cementoblastoma occurring in association with primary teeth in a 5-year-old male patient with a brief review of literature. Only 20 cases of cementoblastoma involving primary teeth were found after the English literature search, the current case being the 21st. Moreover, the deciduous teeth-associated cementoblastomas (14 out of 20) show a distinct predilection for the right side of the face. The current case is the seventh one to involve the left side.
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