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Control of epileptic convulsions by simply electrical activation: a new model-based review.
34 mg/l) (95 % CI, -0.52, to -0.16) p less then 0.05] in participants with T2D following supplementation with resveratrol. No significant publication bias was observed in the meta-analysis. Subgroup and sensitivity analyses indicated that the pooled effects of resveratrol supplementation on CRP level in T2D patients were affected by resveratrol dose and duration of resveratrol. Random-effects meta-regression did not indicate any significant association of CRP level with potential confounders including resveratrol dose, duration of treatment, age and gender of type 2 diabetic patients. CONCLUSION We found a significant reduction in CRP level in patients with type 2 diabetes, who received resveratrol supplementation. OBJECTIVE Carotenoids (including zeaxanthin and lycopene) and phytosterols reportedly confer beneficial effects on metabolic profile and function, which is of clinical importance. Thus, we sought to review the saffron effects on waist circumstance (WC), fasting plasma glucose (FPG), and HA1C concentrations reported in Randomized Control Trials (RCTs). METHOD A comprehensive systematic electronic search was performed in PubMed/MEDLINE, Embase, Google Scholar, Cochrane, Web of sciences, and SCOPUS to identify RCTs up to February 2019 without any language restrictions. The pooled weighted mean difference (WMD) calculated with DerSimonian-Laird random. PRISMA guidelines adhered to for this meta-analysis. RESULT Nine articles with 12 arms containing 595 participants were included in this study. Our study found WC was significantly reduced (WMD -2.18 cm, 95 % CI -4.05, -0.32) and FPG (WMD -6.54 mg/dl, 95 % CI -10.22, -2.85) following saffron intervention. Subgroup analysis highlighted that FPG levels (WMD -10.24 mg/dl, 95 % CI -15.76, -4.72) reduced significantly when intervention duration was longer than twelve weeks. There was no significant effect on HA1C levels (WMD -0.13 mg/dl, 95 % CI -0.31, 0.04) following saffron intervention. CONCLUSION In conclusion, the present study indicates beneficial effects on WC and FPG, following saffron supplementation. OBJECTS Cardiovascular disease (CVD) is one of the leading causes of death worldwide. CVD is associated with increased levels of reactive oxygen species which are pro-inflammatory and can damage the endothelium. The pomegranate fruit is a rich source of phytochemicals with a high antioxidant and anti-inflammatory activity, possessing thus health benefits. This systematic review and meta-analysis aims to evaluate the effect of pomegranate juice on the biomarkers of inflammation and vascular dysfunction. METHODS Studies were identified using the PubMed/Medline and SCOPUS databases. Screening of relevant articles and references was carried out from inception until May 2019. 6-Benzylaminopurine in vivo This systematic review and meta-analysis was performed using the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses (PRISMA) guidelines. RESULTS Overall, 16 randomized controlled trials (RCTs) involving 572 subjects were included in this study. Combining effect sizes from 16 studies, we recorded that pomegranate supplementation significantly reduced hs-CRP, IL-6 and TNF-α (Weighted Mean Diff ;erences (WMD) -6.57 mg/L, 95 % CI -10.04 to -3.10, P = 0.000; WMD -1.68 pg/mL, 95 % CI -3.52, 0.157, P = 0.000; WMD -2.37 pg/mL, 95 % CI -3.67, -1.07, P = 0.00, respectively) levels, when compared to placebo. No significant reduction was found in CRP (WMD 2.19 mg/dL, 95 % CI -3.28, 7.67, P = 0.61), E-selectin (WMD 8.42 ng/mL, 95 % CI -22.9, 39.8, P = 0.599), ICAM (WMD= -17.38 ng/mL, 95 % CI -53.43, 18.66, P = 0.107), VCAM (WMD -69.32 ng/mL, 95 % CI -229.26, 90.61, P = 0.396) or MDA (WMD 0.031 μmol/L, 95 % CI -1.56, 0.218, P = 0.746) comparing pomegranate supplementation to placebo. CONCLUSION We found a significant effect of pomegranate supplementation on hs-CRP, IL-6 and TNF-α in adults. However, the effects of pomegranate supplementation on CRP, E-selectin, ICAM, VCAM or MDA were not significant in this meta-analysis. OBJECTIVES Mind-body therapies (MBT) are a range of practices which improve well-being and have shown promising results in a variety of illness. To inform the application of MBT in health promotion, and intervention designs, we conducted a global review of publication growth and content analysis of studies examining the impacts of MBT on quality of life (QoL) of different patient groups. DESIGN Data from 1990 to 2018 was collected from the Web of Science (WoS). They were analyzed with descriptive statistics (publication volume by year, citations, and countries). The development of research areas overtime was structured using Latent Dirichlet Allocation, and co-occurrence of keywords of titles, and abstracts. RESULTS 3906 studies were obtained, with an exponential increase in recent years. Mindfulness, mental health, cancer, surgery, and QoL are common themes in the literature. Research has explored the efficacy, mechanism, and approaches to deliver MBT in both the general population and the patients. CONCLUSIONS MBT has proven promising in a wide range of medical conditions, not only as a complementary therapy but also been incorporated into health services, especially for chronic diseases. By characterizing the trends in research productivity, and topics, we suggest robust adverse reporting, and guidelines for disease specific MBT should be improved. This global mapping of MBT studies also provides insight for future research, policy, and management direction. OBJECTIVES The results of meta-analyses currently represent the highest level of evidence in modern medicine. Taking the example of radiotherapy and radiochemotherapy-induced oral mucositis and the effects of honey, we analysed six meta-analyses on the topic to assess the quality of the meta-analyses. DESIGN We analysed the various meta-analyses in detail and compared whether the authors have correctly included the various trials or not. RESULTS We found that the quality of these meta-analyses was low. Especially the more recent meta-analyses included trials in which radiotherapy was not part of the medical intervention or where substances other than pure honey were used. CONCLUSIONS It is impossible to determine the underlying reasons why these meta-analyses were able to pass the peer-review system without the request for adequate improvements prior to publication. According to the literature at least 7% of the included meta-analyses revealed false results, but it was assumed that due to limitations of external validity and to the decreased likelihood of updating positive meta-analyses, the true proportion of false positives in the meta-analysis was likely to be higher.
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