Notes

microRNAs since book analysis biomarkers throughout endometriosis people: a systematic evaluation and meta-analysis.
05). Additionally, this did not differ across tear size groups (p>0.05).

Results of this study suggest FI assessed in the Y-view is not different (mean difference<1.0%) from FI of the entire 3D muscle in patients with full-thickness rotator cuff tears. Therefore, the clinical utility of evaluating rotator cuff intramuscular fat infiltration with the Y-view is further supported in patients with full-thickness rotator cuff tears across tear sizes.
Results of this study suggest FI assessed in the Y-view is not different (mean difference less then 1.0%) from FI of the entire 3D muscle in patients with full-thickness rotator cuff tears. Therefore, the clinical utility of evaluating rotator cuff intramuscular fat infiltration with the Y-view is further supported in patients with full-thickness rotator cuff tears across tear sizes.We developed an inductively coupled plasma mass spectrometry (ICP-MS) method using Universal Cell Technology (UCT) with a PerkinElmer NexION ICP-MS, to measure arsenic (As), chromium (Cr), and nickel (Ni) in human urine samples. The advancements of the UCT allowed us to expand the calibration range to make the method applicable for both low concentrations of biomonitoring applications and high concentrations that may be observed from acute exposures and emergency response. Our method analyzes As and Ni in kinetic energy discrimination (KED) mode with helium (He) gas, and Cr in dynamic reaction cell (DRC) mode with ammonia (NH3) gas. The combination of these elements is challenging because a carbon source, ethanol (EtOH), is required for normalization of As ionization in urine samples, which creates a spectral overlap (40Ar12C+) on 52Cr. This method additionally improved lab efficiency by combining elements from two of our previously published methods(Jarrett et al., 2007; Quarles et al., 2014) allowing us to measure Cr and Ni concentrations in urine samples collected as part of the National Health and Nutrition Examination Survey (NHANES) beginning with the 2017-2018 survey cycle. We present our rigorous validation of the method selectivity and accuracy using National Institute of Standards and Technology (NIST) Standard Reference Materials (SRM), precision using in-house prepared quality control materials, and a discussion of the use of a modified UCT, a BioUCell, to address an ion transmission phenomenon we observed on the NexION 300 platform when using higher elemental concentrations and high cell gas pressures. The rugged method detection limits, calculated from measurements in more than 60 runs, for As, Cr, and Ni are 0.23 μg L-1, 0.19 μg L-1, and 0.31 μg L-1, respectively.
In heparin-induced thrombocytopenia (HIT), selected patients are treated with therapies directed at the immune response, intravenous immunoglobulin (IVIG) and therapeutic plasma exchange (TPE). To determine IVIG and TPE characteristics and outcomes in HIT, we analyzed the National Inpatient Sample (NIS) database.

In a population-based analysis of the NIS, we identified hospital discharges of adult patients with a HIT diagnosis. A two-level statistical analysis was performed comparing cases as follows 1) IVIG or TPE vs. none; and 2) IVIG vs. TPE. For each analysis, the primary outcome was in-hospital mortality. Secondary outcomes were thrombotic events, major bleeding, infections, hospital length of stay, and total charges.

Among 22,152 discharges with a HIT diagnosis, 77 (0.34%) and 52 (0.23%) received TPE and IVIG, respectively. In the first level analysis of TPE or IVIG vs. check details no treatment, TPE or IVIG treatment was associated with a higher likelihood of in-hospital mortality (OR=1.85; 95%CI 1.13-3.03, p=0.0104), major bleeding (OR=1.91; 95%CI 1.25-2.93, p=0.0030), gastrointestinal bleeding (OR=1.89; 95%CI 1.08-3.30, p=0.0259), and infection (OR=1.65; 95% CI1.13-2.41, p=0.0095). In the second-level analysis comparing IVIG vs. TPE, there were no significant differences in patient characteristics or outcomes in both unadjusted and adjusted analyses.

In this population-based analysis of HIT, we found similar outcomes of IVIG and TPE-treated cases. Given the small sample size, future studies are needed to confirm this observation.
In this population-based analysis of HIT, we found similar outcomes of IVIG and TPE-treated cases. Given the small sample size, future studies are needed to confirm this observation.
Venous thromboembolism (VTE) may be the first symptom of cancer. Statins are suggested to prevent VTE, but the risk of cancer in VTE patients using statins remains poorly understood.

To examine if VTE is a marker of cancer in users of statins.

We identified all Danish patients during 1996-2017 with a first-time diagnosis of VTE and a filled prescription for a statin within 90days prior to the VTE diagnosis. We classified patients as prevalent users if the first filling of a statin occurred more than one year preceding the VTE diagnosis, and as new users if the first filling occurred within the preceding year. We computed cumulative incidences of cancer, with death as a competing risk, and age-, sex-, and calendar-period standardized incidence ratios (SIRs), comparing the observed cancer incidence with the expected based on national cancer statistics.

Among 9280 (85%) prevalent users of statin and 1580 (15%) new users, the one-year cumulative incidence of any cancer was 6.6 (95% CI 6.1-7.2) for prevalent users and 6.4 (95% CI 5.2-7.6) for new users; the corresponding SIRs were 3.1 (95% CI 2.9-3.3) and 3.5 (95% CI 2.9-4.3). In the second and subsequent years, the SIRs diminished and approached unity for both prevalent (1.1 [95% CI 1.1-1.2]) and new users (1.1 [95% CI 0.9-1.3]).

VTE patients using statins had a 3-fold increased rate of cancer in the first year after diagnosis. A first VTE serves as an important marker of cancer, regardless of statin use.
VTE patients using statins had a 3-fold increased rate of cancer in the first year after diagnosis. A first VTE serves as an important marker of cancer, regardless of statin use.
Açai is a rich source of anthocyanins and has been used as a dietary supplement and as an active pharmaceutical ingredient. Growing evidence indicates that host-microbial interactions played a vital role in the host metabolism. The aim of this study was to investigate the anthocyanin-rich extract of açai (Euterpe oleracea Mart.) fruit (AEA) regarding its antiobesity activity and gut microbiota-modulating effect.

Thirty-six male SPF C57BL/6J mice were randomly divided into three groups and fed a low-fat diet, high-fat diet, or a high-fat diet supplemented with AEA for 14 wk. The antiobesity effect of AEA was evaluated, and the microbial changes were analyzed by 16S rRNA sequencing. Spearman correlation analysis was used to determine the correlations between gut microbiota and obesity-related indicators.

The results showed that AEA treatment alleviated HFD-induced obesity, hepatic steatosis, and insulin resistance. Moreover, AEA supplement changed the structure of the gut microbiota, and significantly enriched Akkermansia muciniphila, which was negatively correlated with the physical biomarkers (e.g., serum glucose, insulin, and triacylglycerols) and the genes involved in lipid metabolism.

AEA alleviated high-fat diet-induced obesity, insulin resistance, and hepatic steatosis. The microbial changes may be one of the potential mechanisms for AEA in improving obesity and obesity-related disorders.
AEA alleviated high-fat diet-induced obesity, insulin resistance, and hepatic steatosis. The microbial changes may be one of the potential mechanisms for AEA in improving obesity and obesity-related disorders.
This study evaluated the adequacy of micronutrient intake from the ketogenic diet (KD) with and without micronutrient supplementation according to age in Brazilian children and adolescents with refractory epilepsy undergoing KD treatment.

This study enrolled children and adolescents with refractory epilepsy who were up to 19 y of age. Nutrient intakes were monitored using 3 d food records before introducing micronutrient supplementation and 3 mo after starting KD treatment. The prevalence of micronutrient inadequacy was estimated by sex and age according to the estimated average requirement cutoff values.

This study included 39 children and adolescents. The KD did not provide enough content of folate, calcium, and magnesium in all patients according to the dietary reference intake. Even after starting supplementation, calcium, phosphorus, and magnesium intake remained inadequate in the majority of patients. The supplementation effectively met the vitamin B
recommendation in all age groups.

KD treatment did not provide adequate levels of the monitored micronutrients. The supplementation improved but did not prevent the inadequacy of micronutrients such as calcium, magnesium, and phosphorus. The results highlight the importance of individual supplementation protocols and the need to monitor micronutrient intake according to age and sex.
KD treatment did not provide adequate levels of the monitored micronutrients. The supplementation improved but did not prevent the inadequacy of micronutrients such as calcium, magnesium, and phosphorus. The results highlight the importance of individual supplementation protocols and the need to monitor micronutrient intake according to age and sex.
To compare radiation dose, contrast enhancement, image noise and heart rate variability in electrocardiography (ECG)-gated computed tomography (CT) ventricular volumetry using a three-dimensional (3D) threshold-based segmentation between the conventional single scan and dual focused scan methods in patients with congenital heart disease.

After matching for age, sex, heart rate during the CT examination, and tube voltage, 96 patients (age range, 7 - 36 years; malefemale = 6333) who underwent ECG-gated CT volumetry using a 3D threshold-based segmentation, were divided into 32 patients who underwent a conventional single scan (group 1) and 64 who underwent dual focused scans (group 2). CT radiation dose, contrast enhancement, image noise, and heart rate variability were compared between the two groups.

Volume CT dose index, dose-length product, and effective dose estimates, in group 1 were significantly higher than those in group 2 (28.4 ± 24.6 mGy vs. 9.7 ± 4.5 mGy, 636.5 ± 572.9 mGy cm vs. 379.5 ± 192.4  lower radiation dose with comparable contrast enhancement and image noise for ECG-gated CT ventricular volumetry using a 3D threshold-based segmentation in patients with congenital heart disease.
This article reviews the pathological mechanisms and progress of imaging of severe frostbite to assist in the search for targets for clinical diagnosis and treatment of severe frostbite. This review also aims to provide strong evidence for clinical diagnosis and treatment of deep frostbite.

The review was based on the summary and analysis of the existing literature, and explored the pathological mechanism of deep frostbite and the advantages and disadvantages of imaging diagnostic methods.

According to the depth of tissue involvement, frostbite is divided into 4 levels. Severe frostbite includes Grade 3 and Grade 4 frostbite. Clinical performance evaluation and imaging diagnostic research have always been the mainstream of severe frostbite diagnosis. Imaging methods focus on vascular patency and tissue vitality. This article introduces angiography, SETCT/CT and MRA, and we summarize the advantages and disadvantages of these imaging methods. We recommend corresponding imaging modalities according to the state of frostbite patients.
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