Notes

Connections associated with 18F-FDG uptake by simply primary tumors together with prognostic components and molecular subtype within ductal cancer of the breast.
Thus, a higher level of nitrosative stress in the late climactic stages is suggested to cause S-nitrosylation of proteins and subsequent apoptosis in the tail tissues. Macrophages were found engulfing the apoptotic cells and cell debris at the distal end of the regressing tail. Interestingly, macrophages were always found to be associated with melanocytes suggesting a close association for clearing cell debris by phagocytosis.Discarded plastic bag is a main component of marine debris, posing potential threats to marine biota. This study was conducted to assess the potential effects of microplastics on juvenile Lates calcarifer. Fish were exposed via diet to two microplastic types from conventional polyethylene (PE) and biodegradable (Bio) plastic bags for 21 days. Antioxidative enzymes activity, intestinal microbiome and proteome were determined. PE and Bio microplastics were found to accumulate in gastrointestinal tracts, and no mortality was observed. Microplastics exposure did not induce significant antioxidant response except for the glutathione reductase (GR) modulation. Intestinal microbiome diversity decreased significantly in PE group based on Simpson index. check details Both types of microplastics induced proteome modulation by down-regulating proteins associated with immune homeostasis. Bio microplastics maintained higher intestinal microbial diversity and induced more proteins alteration than PE microplastics. This study provides toxicological insights into the impacts of conventional and biodegradable microplastics on juvenile L. calcarifer.
Eriodictyol in citrus fruits, Eriodictyon californicum and several Chinese herbal medicines shows great promise for chronic disease prevention, including cancers. However, its role in chemopreventive activities against breast carcinogenesis is unknown.

In the present study, we investigated the chemopreventive effect and the underlying mechanism of eriodictyol on carcinogens-induced breast carcinogenesis in vivo and in vitro.

The carcinogenic transformation in MCF10A cells was induced by the environmental carcinogens in vitro. The chemopreventive effect in vivo was evaluated by using the experimental model of 1-methyl-1-nitrosourea (MNU)-induced mammary tumorigenesis in rats. The activation of the PI3K/Akt pathway was detected by western blot assay; the levels of circular RNAs (circRNAs) were measured by qRT-PCR.

First, eriodictyol significantly reduces cells viability and induces apoptosis in breast cancer cells in a dose-dependent manner in vitro (P<0.05). Next, eriodictyol could effectively supprism may be attributed to targeting circ_0007503 and inhibiting PI3K/Akt pathway.
As a "multi-components and multi-efficacy" complex system, traditional Chinese herbs are universally distributed and applied in treating clinical diseases. However, the efficacy deviation and ambiguous clinical location are affected by different effects and content of components caused by uncertain factors in the production process. It further restricts resource allocation and clinical medication and hinders modernization and globalization. In this study, a precise efficacy determination strategy was innovatively proposed, aiming to quantitatively predict the efficacy of herbs and obtain precise medicinal materials. Quality-markers (Q-markers) characterizing the efficacy are conducive to achieving precise efficacy determination.

With the anticancer efficacy of Astragali radix (AR) as a case, the present study was designed to establish a methodology for precise efficacy determination based on Q-markers characterizing specific efficacy.

Guided by the basic principles of Q-markers, the potential Q-markers tches of AR samples with biased anticancer efficacy. Furthermore, AR samples with higher ECI had higher anticancer efficacy and vice versa.

The precise efficacy determination strategy established in the present study is reliable and proved in the AR case, which is expected to support resource allocation optimization, efficacy stability improvement, and precise clinical medication achievement.
The precise efficacy determination strategy established in the present study is reliable and proved in the AR case, which is expected to support resource allocation optimization, efficacy stability improvement, and precise clinical medication achievement.
Hepatobiliary disease currently serves as an urgent health issue in public due to health-modulating factors such as extension of life expectancy, increasingly sedentary lifestyles and over-nutrition. A definite treatment remains lacking owing to different stages of the disease itself and its intricate pathogenesis. Traditional Chinese medicine (TCM) has been gradually popularized in clinic with the satisfactory efficacy and good safety. Curcumae Rhizoma (called E Zhu, EZ in Chinese) is a representative herb, which has been used to treat hepatobiliary disease for thousands of years.

To systematically summarize the recent research advances on the pharmacological activities of EZ and its constituents, explain the underlying mechanisms of preventing and treating hepatobiliary diseases, and assess the shortcomings of existing work. Besides, ethnopharmacology, phytochemicals, and toxicology of EZ have been researched.

The information about EZ was collected from various sources including classic books about Ch further studies still needed to alleviate hepatotoxicity and expand clinical application.
It provides a preclinical basis for the efficacy of EZ as an effective therapeutic agent for the prevention and treatment of hepatobiliary diseases. Even so, the further studies still needed to alleviate hepatotoxicity and expand clinical application.Naringenin is a flavonoid that can be found in citrus fruits (e.g., Citrus sp). This natural compound is known for its antioxidant activity, antitumor, and neuroprotective potential, also acting directly in controlling the inflammatory response. Topical and transdermal routes are attractive alternatives that could circumvent the low oral bioavailability. However, a simple analytical method capable of determining naringenin in skin layers is still demanded. Thus, this work aimed to validate a selective and straightforward chromatographic method for naringenin determination in skin permeation studies. The developed method uses a reversed-phase C18 column as stationary phase and a mobile phase composed of methanol/phosphoric acid 0.01 M (6535, v/v), eluted at a flow rate of 0.6 mL/min with detection at 290 nm. The method was linear (r2 > 0.99) in a broad concentration range of 0.5-10.0 μg/mL, precise with an overall variation coefficient lower than 2%, and accurate with naringenin recovery from the skin layers higher than 85%. Additionally, the method was sensitive (LD = 0.10 μg/mL, LQ = 0.20 μg/mL), selective against skin matrices as well as naringenin degradation products, and robust regarding methodology parameters. Therefore, the method was suitable to be used in skin permeation studies employing naringenin.People with posttraumatic stress disorder (PTSD) experience a wide array of symptoms, often accompanied by significant functional and quality of life impairments. Evidence-based psychotherapies are effective for alleviating symptoms in this group, but functional outcomes following psychotherapy are understudied. This study aimed to synthesize existing work on functional outcomes of psychotherapy to conduct a meta-analytic investigation examining whether people with PTSD experience significant improvements in functioning and quality of life following a course of psychotherapy. A literature search was conducted for studies reporting results of randomized clinical trials of psychotherapies for people diagnosed with PTSD that included a functional or quality of life outcome measured at pre- and post-intervention. Both between-groups and within-groups analyses were conducted using a random effects model. Fifty-six independent samples were included. Results suggest that, on average, people with PTSD experience significant, moderate improvement in functional outcomes after a course of psychotherapy. Taken together, this meta-analysis represents a substantial advance in our understanding of functional outcomes of psychotherapy for people with PTSD. Findings suggest that psychotherapy is one vehicle through which functional outcomes may be improved for this group, though notably to a lesser degree than symptom improvement.
The amount of people affected by traffic-related air pollution and noise is continuously increasing, but limited research has been conducted on the association between these environmental exposures and functional brain connectivity in children.

This exploratory study aimed to analyze the associations between the exposure to traffic-related air pollution and noise during pregnancy and childhood, and functional brain connectivity amongst a wide-swath of brain areas in preadolescents from 9 to 12years of age.

We used data of 2,197 children from the Generation R Study. Land use regression models were applied to estimate nitrogen oxides and particulate matter levels at participant's homes for several time periods pregnancy, birth to 3years, 3 to 6years, and 6years of age to the age at magnetic resonance imaging (MRI) assessment. Existing noise maps were used to estimate road traffic noise exposure at participant's homes for the same time periods. Resting-state functional MRI was obtained at 9-12years of age.antly in brain areas located in the task positive and task negative networks, in preadolescents from 9 to 12years of age. These results could be an indicator of differential functional connectivity in children exposed to higher levels of air pollution.
This exploratory study found that exposure to traffic-related air pollution during the first years of life was related to higher functional brain connectivity predominantly in brain areas located in the task positive and task negative networks, in preadolescents from 9 to 12 years of age. These results could be an indicator of differential functional connectivity in children exposed to higher levels of air pollution.Liquid crystal monomers (LCMs) are a class of emerging, persistent, bioaccumulative, and toxic organic pollutants. They are detected in various environmental matrixes that are associated with electronic waste (e-waste) dismantling. However, their occurrence and distribution in indoor and outdoor dust on a national scale remain unknown. In this study, a dedicated target analysis quantified a broad range of 60 LCMs in dust samples collected across China. The LCMs were frequently detected in indoor (n = 48) and outdoor dust (n = 97; 37 sampled concomitantly with indoors dust) from dwellings, and indoor dust from cybercafés (n = 34) and phone repair stores (n = 22), with median concentrations of 41.6, 94.7, 106, and 171 ng/g, respectively. No significant spatial difference was observed for the concentrations of the total LCMs among distinct geographical regions (p > 0.05). The median daily intake values of the total LCMs via dust ingestion, dermal contact, and inhalation were estimated at 1.50 × 10-2, 2.90 × 10-2, and 8.57 × 10-6 ng/kg BW/day for adults and 1.47 × 10-1, 1.22 × 10-1, and 2.18 × 10-5 ng/kg BW/day for children, respectively. These estimates suggested higher exposure risks for children and indicated that dust ingestion and dermal contact significantly contribute to the human intake of LCMs. The microenvironmental pollution levels of LCMs together with the potential exposure risks associated with some of these chemicals are of concern for human health.
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