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Function combination employing serious studying for smartphone dependent human action recognition.
Limited studies on multi-omics have been conducted to comprehensively investigate the molecular mechanism underlying the developmental neurotoxicity of perfluorooctanesulfonic acid (PFOS). In this study, the locomotor behavior of zebrafish larvae was assessed under the exposure to 0.1-20 μM PFOS based on its reported neurobehavioral effect. After the number of zebrafish larvae was optimized for proteomics and metabolomics studies, three kinds of omics (i.e., transcriptomics, proteomics, and metabolomics) were carried out with zebrafish larvae exposed to 0.1, 1, 5, and 10 μM PFOS. More importantly, a data-driven integration of multi-omics was performed to elucidate the toxicity mechanism involved in developmental neurotoxicity. In a concentration-dependent manner, exposure to PFOS provoked hyperactivity and hypoactivity under light and dark conditions, respectively. Individual omics revealed that PFOS exposure caused perturbations in the pathways of neurological function, oxidative stress, and energy metabolism. Integrated omics implied that there were decisive pathways for axonal deformation, neuroinflammatory stimulation, and dysregulation of calcium ion signaling, which are more clearly specified for neurotoxicity. Overall, our findings broaden the molecular understanding of the developmental neurotoxicity of PFOS, for which multi-omics and integrated omics analyses are efficient for discovering the significant molecular pathways related to developmental neurotoxicity in zebrafish.Given the increasing attention on the occurrence of microplastics in the environment, and the potential environmental threats they pose, there is a need for researchers to move quickly from basic understanding to applied science that supports decision makers in finding feasible mitigation measures and solutions. At the same time, they must provide sufficient, accurate and clear information to the media, public and other relevant groups (e.g., NGOs). Key requirements include systematic and coordinated research efforts to enable evidence-based decision making and to develop efficient policy measures on all scales (national, regional and global). To achieve this, collaboration between key actors is essential and should include researchers from multiple disciplines, policymakers, authorities, civil and industry organizations, and the public. This further requires clear and informative communication processes, and open and continuous dialogues between all actors. Cross-discipline dialogues between researchers should focus on scientific quality and harmonization, defining and accurately communicating the state of knowledge, and prioritization of topics that are critical for both research and policy, with the common goal to establish and update action plans for holistic benefit. In Norway, cross-sectoral collaboration has been fundamental in supporting the national strategy to address plastic pollution. Researchers, stakeholders and the environmental authorities have come together to exchange knowledge, identify knowledge gaps, and set targeted and feasible measures to tackle one of the most challenging aspects of plastic pollution microplastic. In this article, we present a Norwegian perspective on the state of knowledge on microplastic research efforts. Norway's involvement in international efforts to combat plastic pollution aims at serving as an example of how key actors can collaborate synergistically to share knowledge, address shortcomings, and outline ways forward to address environmental challenges.
The extent of thyroid disruptive effects of phthalates during pregnancy remains unclear.

To investigate the association of maternal urinary phthalates with markers of the thyroid system during early pregnancy.

Urinary concentrations of phthalate metabolites and serum concentrations of thyroid stimulating hormone (TSH), free and total thyroxine (FT4 and TT4) and free and total triiodothyronine (FT3 and TT3) were measured in pregnant women in early pregnancy in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy study (2007-ongoing), a population-based prospective cohort.

In the 1,996 included women, higher di-ethyl-hexyl phthalate (DEHP) metabolites were associated with a lower FT4 (β [SE] for the molar sum -0.13 [0.06], P=0.03) and a higher TSH/FT4 ratio (0.003 [0.001], P=0.03). Higher concentrations of di-iso-nonyl phthalate (DINP) metabolites were associated with a lower TT4 (β [SE] for the molar sum 0.93 [0.44], P=0.03) as well as with lower TT4/FT4 and TT4/TT3 ratios. Highe to better investigate the potential underlying mechanisms of thyroid disruption by phthalates.The addition of nano zero-valent iron (nZVI) has been proven to improve the efficiency of the anammox process, however, the mechnism is not clear. Here, the effect of nZVI on anammox microbial community was studied by metagenomic sequencing methods. It was found that 50 mg/L nZVI indeed promoted the removal of NH4+ and NO2- of the anammox reactor and significantly improved the relative abundance of AnAOB (Ca. Brocadia) from 42.1% to 52.5%. What's more, 50 mg/L nZVI increased the abundance of c-di-GMP synthesized protein from 148 rpmr to 252 rpmr in the microbial community and decreased the abundance of c-di-GMP degradation protein from 238 rpmr to 204 rpmr, which indirectly led to the enrichment of c-di-GMP in the microbial community. The enrichment of c-di-GMP reduced the motility of microorganisms in the reactor and promoted the secretion of extracellular polymers by bacteria, which is beneficial to the formation of sludge particles in the anammox reactor. In conclusion, this research clarified the mechanism of nZVI promoting the anammox process and provided theoretical guidance for the engineering application of anammox.A comprehensive dataset of pollutant concentrations in German urban wastewater systems is available from recently completed monitoring projects. It contains up to 1000 concentration values for each of 79 substances in wastewater treatment plant (WWTP) effluents from 49 sites, and up to 157 values for each of 95 substances in combined sewer overflows (CSOs) from 12 sites. WWTP influents and stormwater outfalls were sampled to a lesser extent. All sampling methods were harmonised and aimed at collecting event or multi-day composite samples over periods of ≥1 year. Among the substances analysed were biocides and pesticides, polycyclic aromatic hydrocarbons, perfluorinated alkyl substances, metals, pharmaceuticals, benzotriazoles, phenols, acesulfame, di-(2-ethylhexyl)phthalate, and hexabromocyclododecanes. find more Occurrence, concentration ranges, and removal rates of selected WWTPs are presented. CSOs can be confirmed as an important pathway of metals and PAH to receiving waters when compared to WWTPs on the basis of annual per capita loads. The derived volume-weighted site mean concentrations are qualified to be used as representative input data for estimation of average substance emissions in large areas, e.g. on river basin scale, if no site-specific data are available. As such, they will contribute to the development of strategies to reduce substance emissions, taking into account not only WWTPs but also stormwater-related discharges.Microplastic particles in stormwater pose significant threats to the environment. This study investigated how effective a stormwater treatment train was at removing rubber, bitumen and other microplastics (incl. fibers, fragments, and paint particles) in the 100-300 µm and >300 µm size fractions from highway runoff. The two treatment trains comprise a gross pollutant trap (GPT) followed by either a vegetated bioretention cell or non-vegetated sand filter. Flow-proportional composite samples were taken from the highway runoff, GPT outflow and the outflow from the two parallel filters during nine rain events to determine overall treatment performance, as well as the performance of individual system components. The identified rubber, bitumen and other microplastic particles mainly represented the 100-300 µm fraction and included high ratios of rubber (30%) and bitumen (60%). Overall, the treatment train efficiently removed rubber, bitumen and other microplastic particles in the 100-300 µm size fraction from the stormwater. The filter cells accounted for a major share of this removal, as the GPT did not reduce microplastic particle concentrations. This observation is likely explained by the fact that the rubber, bitumen and other microplastic particles have a density close to the density of water and thus removal by sedimentation is decreased. This identified an inherent weakness of the system; more specifically, the high microplastic concentrations in the surface water of the GPT means there can be a risk of microplastic release through overflow pits when inflows surpass the system capacity. Despite some differences, both the vegetated bioretention cell and the non-vegetated sand filter removed rubber, bitumen and other microplastic particles to similar extent.Current practice to enhance resilience in Water Resource Recovery Facilities (WRRFs) is to ensure redundancy or back-up for most critical equipment (e.g. pumps or blowers). Model-based assessment allows evaluation of different strategies for quantitatively and efficiently enhancing resilience and justifying the allocation of resources. The goal of this study is to provide guidance for the development of tailored deterministic models of full-scale WRRFs. A framework for model-based resilience assessment is proposed that provides guidance on data collection, model selection, model calibration and scenario analysis. The framework is embedded into the Good Modeling Practice (GMP) Unified Protocol, providing a new application for resilience assessment and an initial set of stressors for WRRFs. The usefulness of the framework is illustrated through a resilience assessment of the WRRF of Girona against power outage. Results show that, for the Girona facility, limited energy back-up can cause non-compliance of WRRF discharge limits in the case of a blower power shut-down of 6 h, and around 12 h when the blower shut-down is also combined with a shut-down of the recirculation pumps. The best option to enhance resilience would be increasing the power back-up by 218%, which allows the plant to run with recirculation pumps and blowers at minimum capacity. In such a case, resilience can be further enhanced by manipulating the air supply valves to optimise the air distribution, to balance oxygen needs in each reactor with the overall system pressure. We conclude that, with industry consensus on what is considered an acceptable level of resilience, a framework for resilience assessment would be a useful tool to enhance the resilience of our current water infrastructure. Further research is needed to establish if the permit structure should accommodate levels sof functionality to account for stress events.Thermal alkaline pretreatment (TAP) of waste activated sludge (WAS) before anaerobic digestion (AD) was reviewed. Focus of the review was on impact of TAP process parameters on biomethane yield (BY) and kinetics of AD and downstream dewatering. With higher initial biodegradability of untreated WAS, effect of TAP on BY decreases. Depending on initial biodegradability, BY increase of 22-97% is expected. Treatment temperatures below 100 °C showed to be as effective as temperatures higher than 100 °C in terms of BY increase. Alkali dosage and resulting initial pH have a significant effect on BY increase and showed to have an optimum range of 40-60 mg NaOH per g total solids (TS) of sludge. It is advised that alkali is dosed based on solids content in WAS and monitored by pH. Treatment time of 1.5-5 h is sufficient for an effective low temperature TAP (T less then 100 °C), with longer treatment times showing no positive impact on BY increase. Load of sludge liquor with organics and nutrients increases with more intensive TAP conditions.
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