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Lanthanide elements have been recently recognized as "new life metals" yet much remains unknown regarding lanthanide acquisition and homeostasis. In Methylorubrum extorquens AM1, the periplasmic lanthanide-dependent methanol dehydrogenase XoxF1 produces formaldehyde, which is lethal if allowed to accumulate. This property enabled a transposon mutagenesis study and growth studies to confirm novel gene products required for XoxF1 function. The identified genes encode an MxaD homolog, an ABC-type transporter, an aminopeptidase, a putative homospermidine synthase, and two genes of unknown function annotated as orf6 and orf7. Lanthanide transport and trafficking genes were also identified. Growth and lanthanide uptake were measured using strains lacking individual lanthanide transport cluster genes, and transmission electron microscopy was used to visualize lanthanide localization. We corroborated previous reports that a TonB-ABC transport system is required for lanthanide incorporation to the cytoplasm. However, cells were able to acclimate over time and bypass the requirement for the TonB outer membrane transporter to allow expression of xoxF1 and growth. Transcriptional reporter fusions show that excess lanthanides repress the gene encoding the TonB-receptor. Using growth studies along with energy dispersive X-ray spectroscopy and transmission electron microscopy, we demonstrate that lanthanides are stored as cytoplasmic inclusions that resemble polyphosphate granules.
Elevated adiposity is often posited by medical and public health researchers to be a risk factor associated with cardiovascular disease, diabetes, and other diseases. These health challenges are now thought to be reflected in epigenetic modifications to DNA molecules, such as DNA methylation, which can alter gene expression.

Here we report the results of three Epigenome Wide Association Studies (EWAS) in which we assessed the differential methylation of DNA (obtained from peripheral blood) associated with three adiposity phenotypes (BMI, waist circumference, and impedance-measured percent body fat) among American Indian adult participants in the Strong Heart Study.

We found differential methylation at 8264 CpG sites associated with at least one of our three response variables. Of the three adiposity proxies we measured, waist circumference had the highest number of associated differentially methylated CpGs, while percent body fat was associated with the lowest. Because both waist circumference and percebe associated with the presence of visceral/abdominal fat than more general measures of adiposity. Our findings confirmed numerous CpG sites previously found to be differentially methylated in association with adiposity phenotypes, while we also found new differentially methylated CpG sites and regions not previously identified.Climate warming is of concern as a key factor in the worldwide decline in insect populations. In Japan, numbers of a common dragonfly in rice paddy fields, Sympetrum frequens, decreased sharply in the 1990s. Because S. frequens migrates to cooler mountains in summer, climate warming has been suggested as one of the main causes of the population decline in addition to agronomic factors. Here, we analysed the relation between summer temperatures and population densities of S. frequens and the related S. infuscatum, which does not migrate to mountains in summer, using published population monitoring data and temperature data from three regions (Toyama, Ishikawa, and Shizuoka) in Japan. Decadal differences in summer temperatures lay within the range of fluctuations among years, suggesting that an increase in summer temperatures cannot explain the past sharp population declines. However, regression analyses using monitoring data from Toyama showed that the population dynamics of both species in autumn are negatively correlated with summer temperatures in the same year. These results suggest that high temperatures in summer directly affect adult mortality to an extent that results in a decrease in population growth.Desaturation is a new method to mitigate liquefaction of sand. selleck inhibitor It aims to prevent liquefaction by generating gas/air in the pores of fully saturated sands, and biogas is one of the most suitable gas. In order to evaluate the long-term sustainability of biogas bubbles, a series sustainability test on biogas bubbles in pores of sand was conducted with a one-dimensional device under hydrostatic condition, hydraulic gradient flow condition and horizontal excitation condition. The variation trend of the retention of biogas bubbles in the pores of soil under the aforementioned conditions was analyzed. Test results indicated that after 72 weeks of monitoring sand samples, biogas bubbles existed stably in the pores of soil under hydrostatic conditions. In hydraulic gradient flow, the stability under upward seepage flow showed a similar trend to that of downward seepage flow. When the hydraulic gradient was constant, the degree of saturation increased in a certain period and finally remained constant. When the hydraulic gradient increased by 0.1, 0.2, 0.3, 0.4, and 0.5, the degrees of saturation increase were 0.8%, 11.5%, 0.5%, 0.1%, and 0%, respectively. After 41,200 cycles with different accelerations, the degree of saturation of the sample increased slightly, and the biogas bubbles basically remained stable.The jaws of vertebrates display a striking diversity in form and function, but they typically open and close like a trapdoor rather than sliding like a saw. Here, we report unique feeding behaviour in the blunt-headed snail-eating snake, Aplopeltura boa (family Pareidae), where the snake cuts off and circumvents the indigestible part (the operculum) of its prey in the mouth using long sliding excursions of one side of the mandible, while the upper jaws and the mandible on the other side maintain a stable grasp on the prey. This behaviour, which we call 'mandibular sawing', is made possible by extraordinarily independent movements of the jaw elements and is a surprising departure from usual feeding behaviour in vertebrates.New cancer characteristics can be discovered by focusing on the process of tumor formation. Cancer stem cells (CSCs) are a key subpopulation, as they are theorized to be at the apex of the tumor hierarchy. We can better understand their function in the tumor hierarchy by using sectioned samples to observe the growth of tumors from their origins as CSCs. In this study, we evaluated the growth of moderate differentiated colorectal cancer from LGR5-positive cells, which is a CSC marker of colorectal cancer, using xenograft and three-dimensional culture models spatiotemporally. These cells express LGR5 at high levels and show CSC phenotypes. To detect them, we used a previously generated antibody that specifically targets LGR5, and were therefore able to observe LGR5-positive cells aggregating into small clusters (sCLs) over the course of tumor growth. Because these LGR5-expressing sCLs formed continuously during growth mainly in the invasive front, we concluded that the structure must contribute significantly to the expansion of CSCs and to tumor growth overall.
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