Notes

Submission associated with imitations among website hosts for that reptile malaria parasite Plasmodium mexicanum.
Five severe floods occurred in the Yangtze River Basin, China, between July and August 2020, and the Three Gorges Reservoir (TGR) located in the middle Yangtze River experienced the highest inflow since construction. The world's largest cascade-reservoir group, which counts for 22 cascade reservoirs in the upper Yangtze River, cooperated in real time to control floods. The cooperation prevented evacuation of 600,000 people and extensive inundations of farmlands and aquacultural areas. In addition, no water spillage occurred during the flood control period, resulting in a world-record annual output of the TGR hydropower station. This work describes decision making challenges in the cooperation of super large reservoir groups based on a case-study, controlling the 4th and 5th floods (from Aug-14 to Aug-22), the efforts of technicians, multi-departments, and the state, and reflects on these. To realize the full potential of reservoir operation for the Yangtze River Basin and other basins with large reservoir groups globally, we suggest (i) improve flood forecast accuracy with a long leading time; (ii) strengthen and further develop ongoing research on reservoir group cooperation; and (iii) improve and implement institutional mechanisms for coordinated operation of large reservoir groups.MicroRNAs (miRNAs) are non-coding small RNAs which play a critical role in the regulation of gene expression in cells. It is known that miRNAs are often expressed as multiple isoforms, called isomiRs, which may have alternative regulatory functions. Despite the recent development of several single cell small RNA sequencing protocols, these methods have not been leveraged to investigate isomiR expression and regulation to better understand their role on a single cell level. Here we integrate sequencing data from three independent studies and find substantial differences in isomiR composition that suggest that cell autonomous mechanisms may drive isomiR processing. We also find evidence of altered regulatory functions of different classes of isomiRs, when compared to their respective wild-type miRNA, which supports a biological role for many of the isomiRs that are expressed.The repeated expansion of East Asian steppe cultures was a key driver of Eurasian history, forging new social, economic, and biological links across the continent. Tofacitinib JAK inhibitor Climate has been suggested as important driver of these poorly understood cultural expansions, but paleoclimate records from the Mongolian Plateau often suffer from poor age control or ambiguous proxy interpretation. Here, we use a combination of geochemical analyses and comprehensive radiocarbon dating to establish the first robust and detailed record of paleohydrological conditions for Lake Telmen, Mongolia, covering the past ~ 4000 years. Our record shows that humid conditions coincided with solar minima, and hydrological modeling confirms the high sensitivity of the lake to paleoclimate changes. Careful comparisons with archaeological and historical records suggest that in the vast semi-arid grasslands of eastern Eurasia, solar minima led to reduced temperatures, less evaporation, and high biomass production, expanding the power base for pastoral economies and horse cavalry. Our findings suggest a crucial link between temperature dynamics in the Eastern Steppe and key social developments, such as the emergence of pastoral empires, and fuel concerns that global warming enhances water scarcity in the semi-arid regions of interior Eurasia.Dithionite-citrate-bicarbonate (DCB) treatment is a classical method for removing iron oxides from soil. The DCB-induced dissolution effects on iron oxides are controversial. In this paper, samples from a typical loess-paleosol sequence in the Chinese Loess Plateau (CLP) and from other aeolian dust deposits in southern China were collected, and changes in the grain size composition and magnetic properties of the samples after DCB treatment were analyzed. The results show that the dissolution of iron oxides in loess-paleosol samples from the CLP is highly grain size dependent. In addition to completely dissolving nanometer-sized pedogenic iron oxides ( 6 μm aeolian iron oxides is negligible. DCB can neither separate pedogenic iron oxides from aeolian iron oxides nor selectively dissolve magnetite or maghemite. Although the total amount of dissolved iron oxides in the profiles from southern China is higher than that in the LC profile from northern China, the submicron- and micron-sized aeolian iron oxides in the latter are more easily dissolved.Dry dipterocarp forests are among the most common habitat types in Thailand. Russulaceae are known as common ectomycorrhizal symbionts of Dipterocarpaceae trees in this type of habitat. The present study aims to identify collections of Russula subsection Amoeninae Buyck from dry dipterocarp forests in Thailand. A multi-locus phylogenetic analysis placed Thai Amoeninae collections in two novel lineages, and they are described here as R. bellissima sp. nov. and R. luteonana sp. nov. The closest identified relatives of both species were sequestrate species suggesting that they may belong to drought-adapted lineages. An analysis of publicly available ITS sequences in R. subsect. Amoeninae did not confirm evidence of any of the new species occurring in other Asian regions, indicating that dry dipterocarp forests might harbor a novel community of ectomycorrhizal fungi. Macromorphological characters are variable and are not totally reliable for distinguishing the new species from other previously described Asian Amoeninae species. Both new species are defined by a combination of differentiated micromorphological characteristics in spore ornamentation, hymenial cystidia and hyphal terminations in the pileipellis. The new Amoeninae species may correspond to some Russula species collected for consumption in Thailand, and the detailed description of the new species can be used for better identification of edible species and food safety in the region.In order to understand the effects of different patterns of prefabricated fractures and grain size compositions on the fracture characteristics, acoustic emission characteristics and mechanical properties of the rock masses. We conducted compression shear experiments on square rock masses with different modes of prefabricated fractures and different grain size compositions. The experimental results showed that five fracture patterns were produced in specimens with different fracture patterns. The first fracture specimen, the fourth fracture specimen and the fifth fracture specimen were all brittle fractures. The other four specimens were not brittle fractures. The fracture patterns, fracture processes and mechanical characteristics of the different fracture pattern rock masses were revealed. The lowest peak shear stresses were found in specimens consisting of two grain size ranges and the highest peak shear stresses were found in specimens consisting of three grain size ranges. The highest shear displacementsn size ranges. The rock mass consisting of three grain size ranges was also the strongest and most difficult to fracture because the grains were more fully embedded in each other.This paper studies the position and stability of equilibrium points in the circular restricted three-body problem under the influence of small perturbations in the Coriolis and centrifugal forces when the primaries are radiating and heterogeneous oblate spheroids. It is seen that there exist five libration points as in the classical restricted three-body problem, three collinear [Formula see text] and two triangular [Formula see text]. It is also seen that the triangular points are no longer to form equilateral triangles with the primaries rather they form simple triangles with line joining the primaries. It is further observed that despite all perturbations the collinear points remain unstable while the triangular points are stable for [Formula see text] and unstable for [Formula see text], where [Formula see text] is the critical mass ratio depending upon aforementioned parameters. It is marked that small perturbation in the Coriolis force, radiation and heterogeneous oblateness of the both primaries have destabilizing tendencies. Their numerical examination is also performed.Skeletal muscle satellite cells cultured on soft surfaces (12 kPa) show improved differentiation than cells cultured on stiff surfaces (approximately 100 kPa). To better understand the reasons for this, we performed an RNA-Seq analysis for a single satellite cell clone (C1F) derived from the H2kb-tsA58 immortomouse, which differentiates into myotubes under tightly regulated conditions (withdrawal of ɣ-interferon, 37 °C). The largest change in overall gene expression occurred at day 1, as cells switched from proliferation to differentiation. Surprisingly, further analysis showed that proliferating C1F cells express Pax3 and not Pax7, confirmed by immunostaining, yet their subsequent differentiation into myotubes is normal, and enhanced on softer surfaces, as evidenced by significantly higher expression levels of myogenic regulatory factors, sarcomeric genes, enhanced fusion and improved myofibrillogenesis. Levels of mRNA encoding extracellular matrix structural constituents and related genes were consistently upregulated on hard surfaces, suggesting that a consequence of differentiating satellite cells on hard surfaces is that they attempt to manipulate their niche prior to differentiating. This comprehensive RNA-Seq dataset will be a useful resource for understanding Pax3 expressing cells.In this study, multi-objective optimization of mechanical properties in friction-stir-welding of AH12 1050 aluminum alloy is performed using a combination of the response surface method and multi-objective particle swarm optimization algorithm. The process parameters are considered as tool pin diameter, shoulder diameter, rotational speed, feed speed, and tool tilt angle. The heat-affected zone's yield strength, fracture strain, impact toughness, and hardness on the advancing and retreating sides are selected as the objective functions. Threaded and simple conical pins are utilized to evaluate the effect of the pin geometry on the specimen mechanical properties. Optimization model outputs are in agree with the obtained experimental results. The effects of process parameters on the mechanical properties of the friction-stir-welded sheets are studied. Results reveal that the lower rotational speed and higher feed speed improve the material strength and hardness. Moreover, the microstructural analysis demonstrates that the proposed methodology can achieve a fine-grained structure with the minimum defects. Improvement in the material flow is observed for the threaded cylindrical pin compared with the conical pin due to the geometric shape of the tool pin leading to more functional mechanical properties. It is found that the combination of the response surface methodology and the multi-objective particle swarm algorithm led to the modeling and optimization of the process with outstanding accuracy and low experimental cost.There is limited information on functional low vision (FLV) in Latin America, especially in individuals under 50 years of age. In the present study, we retrospectively evaluated the medical records of 1393 consecutive subjects seen at a Brazilian tertiary rehabilitation service, from February 2009 to June 2016. We collected sociodemographic, clinical data, and information on optical aids and spectacle prescription. Subjects were divided into three age groups 0 to 14 years old (children), 15 to 49 years old (young adults), and 50 years or older (older adults). The main etiologies leading to FLV in children were cerebral visual impairment (27.9%), ocular toxoplasmosis (8.2%), and retinopathy of prematurity (7.8%). In young adults, retinitis pigmentosa (7.4%) and cone/rod dystrophy (6.5%) were the most frequent, while in older adults, age-related macular degeneration (25.3%) and diabetic retinopathy (18.0%) were the leading causes. Our results indicate that preventable diseases are important causes of FLV in children in the area, and proper prenatal care could reduce their burden.
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