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Ethnopharmacological, compound, as well as pharmacological areas of Halenia elliptica: A comprehensive assessment.
Determine the characteristics of postintensive care syndrome in the cognitive, physical, and psychiatric domains in coronavirus disease 2019 ICU survivors.

Single-center descriptive cohort study from April 21, to July 7, 2020.

Critical care recovery clinic at The Mount Sinai Hospital in New York City.

Adults who had critical illness due to coronavirus disease 2019 requiring an ICU stay of 7 days or more and who agreed to a telehealth follow-up in the critical care recovery clinic 1-month post hospital discharge.

None.

Patient-reported outcome measures assessing physical and psychiatric domains were collected electronically, a cognitive test was performed by a clinician, and clinical data were obtained through electronic medical records. Outcome measures assessed postintensive care syndrome symptoms in the physical (Modified Rankin Scale, Dalhousie Clinical Frailty Scale, Neuro-Quality of Life Upper Extremity and Lower Extremity Function, Neuro-Quality of Life Fatigue), psychiatric (Insomnia Severitress Disorder Checklist for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, scores suggestive of posttraumatic stress syndrome diagnosis. In the Telephone Montreal Cognitive Assessment, 9% had impaired cognition.

Survivors of critical illness related to coronavirus disease 2019 are at high risk of developing postintensive care syndrome. These findings highlight the importance of planning for appropriate post-ICU care to diagnose and treat this population.
Survivors of critical illness related to coronavirus disease 2019 are at high risk of developing postintensive care syndrome. These findings highlight the importance of planning for appropriate post-ICU care to diagnose and treat this population.
Evaluate the safety and efficacy of epi-off corneal cross-linking (CXL) in adolescents with progressive keratoconus (KC).

Private clinical practice DESIGN Nonrandomized prospective clinical trial METHODS 230 adolescent patients aged 10-19 years old with progressive keratoconus (increasing maximum keratometry (Kmax) or astigmatism of ≥ 1 D associated with decreased corrected distance visual acuity (CDVA)) underwent CXL. Exclusion criteria were age at time of CXL < 10 years or > 19 years, corneas that were thinner than 400 μm or demonstrated central corneal scarring, history of herpetic eye disease, or pregnancy or nursing. Follow up examinations of uncorrected distance visual acuity (UDVA), CDVA, Kmax and minimum pachymetry occurred on 130 eyes at 1 year, 77 eyes at 2 years and 55 eyes at 3 years post-CXL.

UCVA significantly improved from preop to 1, 2 and 3 years post-CXL. CDVA significantly improved from preop to 1, 2 and 3 years post-CXL. Kmax significantly reduced (improved) from preop to 1 and 3 years post-CXL and reduced (improved) (p=0.22) from preop to two years post-CXL. Minimum pachymetry decreased significantly from preop to 1, 2 and 3 years post-CXL.

CXL in patients aged 10-19 years old is safe and efficacious, halts progression of KC and can improve UCVA, CDVA and Kmax. Minimum pachymetry decreases and stabilizes post-CXL. Ophthalmologists should encourage adolescent patients with KC to obtain prompt evaluation and possible CXL to halt progression of the disease.
CXL in patients aged 10-19 years old is safe and efficacious, halts progression of KC and can improve UCVA, CDVA and Kmax. Minimum pachymetry decreases and stabilizes post-CXL. Ophthalmologists should encourage adolescent patients with KC to obtain prompt evaluation and possible CXL to halt progression of the disease.Corneal crosslinking is an FDA approved therapy to stiffen the cornea and prevent progression of corneal ectasia in patients with keratoconus. The standard procedure involves removal of the corneal epithelium (epithelial-off) prior to treatment. Variations to the standard procedure include accelerated crosslinking and transepithelial procedures. This study reviewed what is known regarding the risk for infection following epithelial-off crosslinking, the spectrum of pathogens, and clinical outcomes. Twenty-six publications were identified. All eyes were fit with a bandage contact lens post-operatively. Available data indicate that the overall frequency of infectious keratitis after epithelium-off crosslinking is low. Bacterial infections are the most common, presenting an average of 4.8 days after surgery. The use of steroids and bandage contact lenses in the immediate postoperative period and/or a history of atopic or herpetic disease were associated with infection. These patients require intense post-operative care with prophylactic anti-viral therapy when appropriate.
To quantitatively and intraindividually compare surface light scattering for 7 years after implantation of Clareon and AcrySof intraocular lenses (IOLs).

Miyata Eye Hospital, Miyazaki, Japan.

Retrospective comparative case series.

Clinical records of eyes that had contralateral implantation of SN60WF and SY60WF IOLs were reviewed. Light scattering on the anterior surface of IOLs, corrected distance visual acuity (CDVA), and mesopic and photopic contrast sensitivities were examined at 1 year, 3 years, and 7 years postoperatively, and they were intraindividually compared.

34, 19, and 16 patients visited at 1 year, 3 years, and 7 years postoperatively, respectively. Surface light scattering in eyes with SY60WF IOL was significantly reduced, and the rate of increase was 2.74 computer compatible tapes per year. Although there were prominent increases in eyes with SN60WF IOL, no statistically significant difference was found in their CDVA and contrast sensitivities.

In eyes with Clareon IOLs, the development of surface light scattering was suppressed up to 7 years. The increase rate demonstrated that the visual acuity would be least deteriorated up to 12 years postoperatively, whereas the influence of straylight induced should be investigated.
In eyes with Clareon IOLs, the development of surface light scattering was suppressed up to 7 years. The increase rate demonstrated that the visual acuity would be least deteriorated up to 12 years postoperatively, whereas the influence of straylight induced should be investigated.
To characterize safety of optic exchange using a modular lens.

3 study sites (New Zealand, Philippines).

Prospective clinical study.

Harmoni modular intraocular lens (HMIOL) with separate base and optic components was implanted in the study eye (monovision target -1.5 D). Contralateral eyes received standard monofocal lenses. Subjects could elect optic exchange 3 months after primary implantation. Adverse events (AEs) and endothelial cell loss (ECL) were assessed through 12-months follow-up.

114 subjects successfully received HMIOL and 114 received control lens in contralateral eye. At month 3, 65 HMIOL eyes had optic exchange due to unsatisfactory visual outcome from high monovision (Exchange cohort); 49 eyes received no exchange (No Exchange cohort). Exchange, No Exchange, and Control cohorts reported ocular AEs in 10 (15%), 6 (12%), and 14 (12%) eyes. No posterior capsular rupture occurred during optic exchange procedures. Short-term (12-month) posterior capsule opacification (PCO) evaluation showed all eyes had PCO grade ≤1 at month 12; no YAG capsulotomy was performed in the Exchange cohort. No Exchange and Exchange cohorts had similar ECL at 3 months versus preoperative baseline (-4.5%, n=48 and -4.0%, n=65). RGFP966 molecular weight In the Exchange cohort, additional 2.7% ECL occurred 3 months after optic exchange compared with pre-exchange baseline; ECL was significantly below the 14% threshold (P<0.001) and was 5.8% at 12 months.

HMIOL safety outcomes were comparable with standard monofocal lenses; HMIOL may provide an effective method for correcting postoperative refractive errors.
HMIOL safety outcomes were comparable with standard monofocal lenses; HMIOL may provide an effective method for correcting postoperative refractive errors.
To gauge the value of total keratometry (TK) to estimate corneal power change in eyes that underwent SMILE for treatment of myopia or myopic astigmatism.

Department of Ophthalmology, Ludwig-Maximilians-University and SMILE Eyes Clinic Munich Airport, Munich, Germany.

Prospective cross-sectional trial.

A total of 40 eyes of 40 patients who had undergone myopic SMILE were enrolled in this prospective study. Total corneal refractive power (TCRP; Pentacam HR; Wetzlar, Germany) and TK (IOL Master 700; Carl Zeiss Meditec AG, Jena, Germany) values were compared to the clinical history method (CHM). The surgically induced changes in TCRP (ΔTCRP) and TK (ΔTK) were also compared to the changes in spherical equivalent on the corneal plane (ΔSEco).

The correlation between TK and CHM (R2=0.91, p<.001) was stronger than between TCRP and CHM (R2=0.87, p<.001). As compared with the CHM, TCRP underestimated corneal power by a mean relative error of 0.59 D and TK by 0.17 D. Linear regression analysis of ΔTCRP/ΔTK and the difference between preoperative and postoperative manifest refraction spherical equivalent at the corneal plane (Δ SEco) showed stronger correlation in ΔTK (R2=0.88), than in ΔTCRP (R2=0.82).

The findings endorse TK as an accurate measure for corneal power after myopic SMILE.
The findings endorse TK as an accurate measure for corneal power after myopic SMILE.
To validate and evaluate the use of a new biomechanical index known as the CBI-LVC (Corvis Biomechanical Index-Laser Vision Correction) as a method for separating stable post-LVC eyes from post-LVC eyes with ectasia.

Patients were included from 10 clinics/9 countries.

Retrospective, multi-center, clinical study.

The study was designed with two purposes to develop the CBI-LVC, which combines dynamic corneal response parameters (DCR) provided by a high-speed Scheimpflug camera (Corvis ST, Oculus, Germany) and then to evaluate its ability to detect post-LVC ectasia. The CBI-LVC includes Integrated Inverse Radius, Applanation 1(A1) Velocity, A1-Deflection Amplitude, Highest Concavity-dArc Length, Deformation Amplitude ratio-2mm, and A1-ArcLength mm. Logistic regression with Wald forward stepwise approach was used to identify the optimal combination of DCRs to create the CBI-LVC, and then separate stable from LVC-induced ectasia. Eighty percent of the database was used for training the software and 20% for validation.

736 eyes of 736 patients were included (685 stable LVC, and 51 post-LVC ectasia). The ROC curve analysis showed an AUC of 0.991 when applying CBI-LVC in the validation dataset and 0.998 in the training dataset. A cut-off of 0.2 was able to separate stable LVC from ectasia with a sensitivity of 93.3% and a specificity of 97.8%.

The CBI-LVC was highly sensitive and specific in distinguishing stable from ectatic post-LVC eyes. We suggest using CBI-LVC in routine practice, along with topography and tomography, to aid the early diagnosis of post-LVC ectasia and allow intervention prior to visually compromising progression.
The CBI-LVC was highly sensitive and specific in distinguishing stable from ectatic post-LVC eyes. We suggest using CBI-LVC in routine practice, along with topography and tomography, to aid the early diagnosis of post-LVC ectasia and allow intervention prior to visually compromising progression.
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