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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are typically described as focusing on practical aspects of design that include the recruitment and consent process, as well as adherence and the use of standard equipment.

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Pragmatic Software, a software firm offers a range of casino games to online gambling platforms. Its iGaming solutions are utilized by the leading operators and land-based casinos. The company offers front-end website design tools, analysis and promotions, marketing, security payment systems, customer support and bug reporting. The company also provides security, high-quality graphics, gameplay and security.


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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for pragmatic trials to be valid and helps to reduce the chance of bias in the results. However too much heterogeneity could result in problems with the design of the trial.

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Pragmatic Play is renowned for its top-notch games, and for providing a superior user experience. Its software is accessible on mobile devices and in a variety of languages. It has been recognized as one of the top gaming platforms for casinos despite its relative infancy. Wolves is one of its latest releases which is a five-reel slot machine with a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

The goal of pragmatic trials is to simulate real-life scenarios and gain maximum credibility externally. They are typically requested by practitioners and policymakers in order to inform their decisions. They are also a good way to identify the cause-effect relationship between an intervention and its outcomes. However, they should not be used to replace explanation studies.

The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials that inform the practice and policy decisions. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool sought to define the characteristics of a practical trial that include the recruitment process, the design and implementation of the intervention, and the follow-up.

There is a positive increase in the number of pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health sciences community is becoming more acquaint to the issue of pragmatic thinking. It is important to remember that the majority of these trials were conducted in primary care settings.

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