Notes

Phytochemical and Healing Potential involving Citrus fruit grandis (L.) Osbeck: A Review.
Sexualized injecting drug use ("SIDU") is a phenomenon associated with a wide array of high-risk injecting and sex-related practices. This scoping review establishes what is known about MSM and SIDU to assess implications for health care and policy. Characteristics of MSM for "SIDU" may include being on anti-retroviral treatment and urban residency with drivers being challenging social taboos; a search for intimacy; convenience of administration; relationship breakdown and increased restrictions in clubs and saunas. Attraction for use appears to be enhancement or prolongation of sexual experiences/pleasure; intimacy and the facilitation of a range of potentially "unsafe" sexual activity. Traditional services are ill-equipped to address "SIDU" because of a lack of knowledge of practices, lack of associated vocabulary, and a failure to integrate sexual health with drug services. For effective responses, these issues need to be addressed.
Thyroid uptake and scan (TUS) is a clinical tool used for differentiation of thyrotoxicosis etiologies. Although guidelines recommend ordering a TUS for evaluation of low TSH levels, no specific value is defined. This study aimed to determine a TSH cutoff at which TUSs yield a greater likelihood of successful determination of etiology to avoid unnecessary testing.

This was a retrospective study on 137 patients seen by an endocrinologist who underwent TUS for evaluation of low TSH (<0.4 μU/mL). A receiver operating curve analysis was performed to determine the TSH cutoff with maximal sensitivity and specificity for prediction of diagnostic utility.

Ninety percent of TUSs (n=123) led to a diagnosis, while 10% (n=14) were inconclusive or normal. Diagnoses included Graves' diseases (52%), toxic multinodular goiter (19%), thyroiditis (12%), and solitary toxic adenoma (7%). The median TSH value was 0.008 μU/mL (IQR 0.005, 0.011), and the median free T4 value was 1.7 μU/mL (IQR 1.3, 2.8). The ROC analysis produced an area under the curve of 0.86. The optimal TSH cutoff value was 0.02 μU/mL (sensitivity 80%, specificity 93%) for prediction of diagnostic yield.

This study demonstrates that TSH is a useful predictor of the utility of TUS in yielding an etiology of thyrotoxicosis. Our analysis showed that TUS had a greater likelihood of determining an etiology when TSH was ≤0.02 μU/mL. This information can help clinicians avoid unnecessary cost and patient time burden when TUS is unlikely to aid in determining the etiology of thyrotoxicosis.
This study demonstrates that TSH is a useful predictor of the utility of TUS in yielding an etiology of thyrotoxicosis. Our analysis showed that TUS had a greater likelihood of determining an etiology when TSH was ≤0.02 μU/mL. This information can help clinicians avoid unnecessary cost and patient time burden when TUS is unlikely to aid in determining the etiology of thyrotoxicosis.Slips, trips and other movement disturbances account for 20 to 30% of recorded occupational accidents (OAs). The causal representations of these accidents hamper their prevention. An analysis method dedicated to occupational accidents with movement disturbance (OAMDs) has been developed to change these representations. In France, the causal tree method (CTM) is very commonly used for analysing OAs. An initial version of an OAMD analysis method, which overcomes the problems encountered when analysing these accidents using the CTM, has been developed. This OAMD analysis method was reviewed by six targeted prevention officers and as a result some proposals have been discarded and this initial version has been transformed into three additional CTM modules. The purpose of these modules is to identify human and organisational factors and provide a formal representation of damage caused, beyond bodily injuries. Practitioner summary A method for analysing occupational accidents triggered by a slip, a trip or any other movement disturbance has been developed in consideration of the practices and constraints in companies. In particular, this method allows us to highlight the human and organisational factors involved in the accident situation. Abbreviations OA occupational accident; OAMD occupational accident with movement disturbance; CTM causal tree method.The ADAMs family belongs to the transmembrane protein superfamily of zinc-dependent metalloproteases, which consists of multiple domains. These domains have independent but complementary functions that enable them to participate in multiple biological processes. Among them, ADAM9 can not only participate in the degradation of extracellular matrix as a metalloprotease, but also mediate tumor cell adhesion through its deintegrin domain, which is closely related to tumor invasion and metastasis. It is widely expressed in a variety of tumor cells and can affect the proliferation, invasion and metastasis of related cancer cells. We provide our views on current progress, its increasing importance as a strategic treatment goal, and our vision for the future of ADAM9.The novel SARS-CoV-2 is the etiological agent causing the Coronavirus disease 2019 (COVID-19), which continues to become an inevitable pandemic outbreak. Over a short span of time, the structures of therapeutic target proteins for SARS-CoV-2 were identified based on the homology modelled structure of similar virus, SARS-CoV that transmitted rapidly in 2003. Since the outset of the disease, the research community has been looking for a potential drug lead. Out of all the known resolved structures related to SARS-CoV-2; 3-chymotrypsin (3 C) like protease (3CLpro) is considered as an attractive anti-viral drug compound on the grounds of its role in viral replication and probable non-interactive competency to bind to any viral host protein. To the best of our knowledge, till date only one compound has been identified and tested in-vitro as a potent inhibitor of 3CLpro protein, addressed as N3 (PubChem Compound CID 6323191) and is known to bind irreversibly to 3CLpro suppressing its activity. Using computational approach, we intend to identify a probable natural fungal metabolite to interact and inhibit 3CLpro. Here after performing docking and molecular dynamics of various small molecules derived as a secondary metabolite from fungi, we propose Flaviolin as potent inhibitor of 3CLpro of novel Coronavirus SARS-CoV-2. Communicated by Ramaswamy H. Sarma.Most research documenting bias against older adults has been conducted in individualistic and industrialized cultures. In the current study, we examined cultural variation in attitudes toward older adults and subjective age in a large sample of 911,982 participants (Mage = 27.42, SD = 12.23; 67.6% women) from 68 different countries (Msize = 12,077; Mdnsize = 425.5). We hypothesized that age bias would be lower among those living in highly collectivistic countries. We found that living in collectivistic countries was associated with less implicit and explicit age bias, and greater feelings of warmth toward older adults compared with highly individualistic countries. Given the impact of age bias and prejudice on both the targets and perpetrators of bias, further research is needed to examine the causes of and interventions for bias against older adults.When studying ball kicking, conventional low-pass filters may distort kick leg kinematics near the time of foot-to-ball contact, leading to flawed practical interpretation of the skill. Time-frequency filters are a viable alternative but are not widely used. This study compared a fractional Fourier filter (FrFF) with conventional filters (CF) methods for estimating common parameters used to define kicking performance. Instep kicks from 23 experienced soccer players were captured by 3D motion analysis (1000 Hz), and kick leg foot velocities, knee angular velocities and ankle dorsi-plantarflexion angles compared between the FrFF and variations of a Butterworth CF. The FrFF and CFs using a higher cut-off frequency (>70 Hz) successfully detected lower leg motion prior to, during and following impact, whereas CFs with low cut-off frequencies ( less then 20 Hz) attenuated motion near impact. Tinengotinib cell line Truncating data at impact provided valid pre-impact kinematics, but ignored information thereafter. Rather than decelerating the lower leg to conserve accuracy, 'kicking through the ball' should be considered a valid coaching cue. Further, controlling ankle plantar flexion to ensure efficient impact mechanics may be important for skilled kicking. Practitioners should consider how choice of filter will affect their data, and use of time-frequency methods can help inform empirically grounded coaching practices.Biological processes are accomplished by the coordinated action of gene products. Gene products often participate in multiple processes, and can therefore be annotated to multiple Gene Ontology (GO) terms. Nevertheless, processes that are functionally, temporally and/or spatially distant may have few gene products in common, and co-annotation to unrelated processes probably reflects errors in literature curation, ontology structure or automated annotation pipelines. We have developed an annotation quality control workflow that uses rules based on mutually exclusive processes to detect annotation errors, based on and validated by case studies including the three we present here fission yeast protein-coding gene annotations over time; annotations for cohesin complex subunits in human and model species; and annotations using a selected set of GO biological process terms in human and five model species. For each case study, we reviewed available GO annotations, identified pairs of biological processes which are unlikely to be correctly co-annotated to the same gene products (e.g. amino acid metabolism and cytokinesis), and traced erroneous annotations to their sources. To date we have generated 107 quality control rules, and corrected 289 manual annotations in eukaryotes and over 52 700 automatically propagated annotations across all taxa.
Actinic keratosis (AK) is a pre-cancerous skin lesion, associated with development of squamous cell carcinoma. Current treatment options are limited.

To compare the efficacy and safety of topical 5-fluorouracil cream (5-FU) and potassium hydroxide 5% (KOH) in the treatment of AK.

Eighteen patients with AK applied KOH solution or 5-FU on each side of their scalp/face, randomly. The efficacy and safety of these treatments were compared.

Thirteen (118 lesions) and ten (83 lesions) patients were successfully followed for one and three months, respectively. After one month, KOH showed a better clinical response (81% vs. 58%;
-value = 0.007) and dermoscopic response (KOH, 65% vs. 5-FU, 46%;
-value = 0.04); while no differences were noted after three months (clinical response, 83% vs.70%,
-value = 0.1; dermoscopic response, 76% vs. 59%,
-value = 0.1). No significant differences in the recurrence rate of the lesion between the two groups were noted at the end of the third month (
-value = 0.5). Regarding the safety of the treatments, the risk of developing erythema, scaling, sand swelling was higher in 5-FU group (
-value < 0.0001, for all), while more patients in KOH group had erosion and ulcer (
-value < 0.001 for both). KOH was up to 96% less expensive than 5-FU.

Low number of patients and short-term follow-up limited the analysis.

KOH solution offers a faster and less expensive resolution of AK lesions than does 5-FU.

IRCT20180909040978N1.
IRCT20180909040978N1.
Website: https://www.selleckchem.com/products/tinengotinib.html