Notes

The interaction regarding Rac1 task, ubiquitination and GDI binding and its particular consequences for endothelial mobile or portable scattering.
2% with LN metastasis. Although the majority of patients had a low risk of recurrence/persistence (78%), 75% were submitted to RAI therapy. Incomplete response (20.7%) was associated with multifocality (p=0.041; OR=1.619) and metastatic LN (p=0.041; OR=1.868). These variables were strongly correlated (p=0.000; OR=3.283). No cut-off of tumor size was identified as a predictor of incomplete response by the receiver operating curve analysis. RAI treatment did not influence the response of patients with multifocality or LN metastasis.

Multifocality and LN metastasis are independent risk factors for incomplete response in TMC patients and are strongly correlated. Additional RAI therapy was not associated with a more favorable response in these subgroups.
Multifocality and LN metastasis are independent risk factors for incomplete response in TMC patients and are strongly correlated. Additional RAI therapy was not associated with a more favorable response in these subgroups.
Galanin is a neuropeptide which has effects not only on metabolic syndrome but also on reproduction. Glypican-4 is an adipokine associated with insulin sensitivity by interacting directly with the insulin receptor. This study evaluated serum concentrations of galanin and glypican-4 in relation with the hormonal profile as well as metabolic and cardiovascular risk factors in patients with and without polycystic ovary syndrome (PCOS).

A total of 44 women with PCOS and 44 age-matched controls were eligible. Hirsutism scores, hormonal profile, metabolic and cardiovascular risk factors as well as galanin and glypican-4 levels were evaluated in each subject.

Women with PCOS exhibited lower levels of galanin (20.2 pg/mL versus 26.4 pg/mL, p = 0.002) and higher concentrations of glypican-4 (3.1 ng/mL versus 2.6 ng/mL, p < 0.001) than controls. Both adipokines were correlated positively with body mass index (BMI), insulin, triglyceride and Homeostasis Model Assessment (HOMA) index; glypican-4 also showed posiogenesis of PCOS, in which metabolic cardiovascular risks are increased.
To investigate the association between plasma Hydrogen Sulfide (H
S) levels and visceral fat area (VFA) among Chinese young men.

This cross-sectional study involved 156 Chinese male subjects, aged 18-45 years, who visited the First Hospital of Qinhuangdao (Hebei, China) in 2014 for annual health check-up. Participants were categorized into low (VFA < 75.57 cm
), medium (75.57 cm
≤ VFA<100.37 cm
), and high (VFA ≥ 100.37 cm
) (n = 52/group). We estimated VFA and plasma H
S levels by using bioelectrical impedance analysis and a fluorescence probe-based approach, respectively. The associations of H
S with VFA and obesity anthropometric measures were assessed.

In the high VFA group, the body mass index (BMI, 30.4 ± 2.45 kg/m
), total body fat (TBF, 27.9 ± 3.23 kg), plasma H
S (3.5 µmol/L), free fatty acid (FFA, 0.6 ± 0.24 mmol/L), triglyceride (TG, 2.0 mmol/L), and total cholesterol (TC, 5.5 ± 1.02 mmol/L) levels were significantly higher than that of those of the low and medium VFA groups, respectively (
< 0.05). Plasma H
S levels were found to be inversely correlated with VFA, TBF, waist circumference, BMI, FFA, LnFINS, LnHOMA-IR, LnTG, TC, and LDL-C (
< 0.05). Multiple backward stepwise regression analysis revealed an inverse correlation of plasma H
S levels with FFA (β = -0.214,
= 0.005) and VFA (β = -0.429,
< 0.001), independent of adiposity measures and other confounding factors.

VFA was independently and inversely associated with plasma H
S levels among Chinese young men. Therefore, determining plasma H
S levels could aid in the assessment of abnormal VAT distribution.
VFA was independently and inversely associated with plasma H2S levels among Chinese young men. Therefore, determining plasma H2S levels could aid in the assessment of abnormal VAT distribution.
The purpose of this study was to investigate the heterogeneity of the association between glycemic variability and oxidative stress markers in T1DM patients under daily life insulin treatment.

We studied, in a cross-sectional analysis, 76 T1DM patients without clinical chronic diabetes complications and 22 healthy individuals. Were evaluated the short-term glycemic variability (STGV), long-term glycemic variability (LTGV), oxidative stress markers [8-isoprostaglandin-F2α (Ur-8-iso-PGF2α), nitric oxide (NO), thiobarbituric acid reactive substances (TBARS) and erythrocytes reduced/oxidized glutathione (GSH/GSSG)] and biochemical dosages (glycaemia, HbA1c, lipidogram, albuminuria).

Plasmatic NO was positively associated with LTGV (last year average of HbA1c) (8.7 ± 1.6% or 71 ± 18 mmol) (rS 0.278; p 0.042). Plasmatic TBARS, erythrocytes GSH/GSSH and Ur-8-iso-PGF-2α didn't show correlation with glycemic variability. GSH/GSSG was inversely correlated with LDL-cholesterol (rS - 0.417; p 0.047) and triglycerides (rS -0.521; p 0.013). Albuminuria was positive correlated with age (rS 0.340; p 0.002), plasmatic NO (rS 0.267; p 0.049) and TBARS (rS 0.327; p 0.015).

In daily life insulin treatment, young T1DM patients have higher plasmatic NO than healthy subjects. However, the correlation between glycemic variability and oxidative stress markers is heterogeneous. Lipid profile and albuminuria are associated with different oxidative stress markers. These data collaborate to explain the controversial results in this issue.
In daily life insulin treatment, young T1DM patients have higher plasmatic NO than healthy subjects. However, the correlation between glycemic variability and oxidative stress markers is heterogeneous. Lipid profile and albuminuria are associated with different oxidative stress markers. These data collaborate to explain the controversial results in this issue.Special diets are used for the treatment and prevention of diseases of the digestive system, taking into account individual food intolerance and possible allergic reactions. The monotony of the diet due to the limited range of recommended foods and dishes negatively affects both the effectiveness of the treatment of gluten intolerance, and the provision of the body with essential and replaceable nutrients. The aim of this study was to determine the selenium content in the flour of gluten-free crops (rice, corn, buckwheat and amaranth), their mixtures, as well as in dishes (pancakes) from a mixture of amaranth and buckwheat flours. Material and methods. The following raw materials were used in the study amaranth flour, unboiled buckwheat groats, whole grain rice flour and corn flour. By mixing the components in a laboratory mixer, dry gluten-free compositions were obtained a mixture of amaranth flour and flour from native buckwheat; a mixture of amaranth and rice flour and a mixture of amaranth and corn flour content in pancakes made from mixtures of amaranth flour and native buckwheat flour varied from 290 to 326 μg/kg. The calculation showed that the consumption of a portion of pancakes (50 g) by school-age children will satisfy their daily requirement for selenium by 7.3-8.1%. Conclusion. Regular inclusion of amaranth-based foods in the diet of children with gluten intolerance can positively affect the elimination of selenium deficiency.In professional athletes who adapt to intense physical training and psycho-emotional stress, the formation of oxidative stress is shown. This fact determines the expediency of targeted correction of disorders of the balance of pro- and antioxidant systems in blood and tissues caused by intense physical training. The aim of the work was to study the effect of vitamin-mineral complex on the parameters of oxidative blood metabolism in professional athletes. Material and methods. The prospective study included 74 professional athletes representing cyclic sports and randomized into 2 groups the main group (n=42), who personalized received one of two vitamin-mineral complexes (with different concentrations of antioxidants), and a control group (n=32), who received a placebo. The duration of the course of daily intake of vitamin-mineral complex, an additional source of vitamins C, E, A, D, group B, minerals and trace elements, a source of β-carotene (1.5 mg), lutein (4.5 mg) and L-carnitine, was 30 days. The parametvitamin-mineral complex, allowed to optimize the state of oxidative metabolism of athletes blood plasma.The article presents modern approaches to dietary support for patients with diabetic nephropathy (DN). The possibility of using the developed specialized products (SP), modified by protein, fat and carbohydrate composition, containing food ingredients with hypoglycemic, hypolipidemic and antioxidant effects is presented. The aim - development of a formulation and technology for producing SP with modified chemical composition and energy value, intended for inclusion in a low-protein diet for patients with DN. Material and methods. When developing the SP formulation, soy protein isolate, monoand polyunsaturated fatty acids, soluble dietary fiber, fat- and water-soluble vitamins, tracelements, curcumin, taurine, flavoring and aromatic additives were used. Results. The chemical composition and organoleptic characteristics of two SPs have been determined. Quizartinib A technology has been developed for producing SP in the form of instant drinks, which consists in stage-by-stage mixing of prescription ingredients, which ensures uniform distribution of minor biologically active substances. The conducted studies of the organoleptic parameters of the developed SPs showed an average overall score of 4.8 and 4.9 on a 5-point scale. Conclusion. Taking into account the technological and organoleptic compatibility of the selected ingredients, formulations and technologies for preparing SP have been developed, which are powdery multicomponent mixtures for preparing drinks for use in the complex therapy of patients with DN.In modern society, distress has become a widespread condition that negatively affects the functioning of all systems of the human organism. The study of biological mechanisms and changes in the organism under the influence of stress, as well as methods of their leveling, are relevant in medicine, animal science and veterinary medicine. Pigs are an excellent biological model that is closest to humans. The aim of the research was to study the hematological and biochemical parameters of pigs out of and under stress, including against the background of daily consumption of the flavonoid dihydroquercetin (DHQ) with feed. Material and methods. The research was conducted in the experimental yard of the L.K. Ernst Federal Science Center for Animal Husbandry on 3 groups of pigs [F2 hybrid (large white×Landrace)×Duroc] with an initial body weight of 30-35 kg (n=27). Group 1K consisted of control animals not exposed to stress (n=9); group 2K - control animals subjected to simulated stress by the rearrangement of animals, within the physiological norm.Oxidative and immune dysfunctions during physical exertion can be associated with a violation of enzyme systems and antioxidant protection, the state of innate and adaptive immunity. This creates the preconditions for their pharmacological correction. The aim of this review is to summarize and analyze modern data on the role of curcumin, one of the components of the extract of turmeric rhizomes (Curcuma longa), in the correction of oxidative stress and immune disorders during physical exertion. Material and methods. When writing the review, a search has been carried out for the original articles presented in PubMed, Web of Science, Google Scholar databases, eLIBRARY.RU and CyberLeninka platforms, with a randomized controlled crossover or parallel design, in which the use of curcumin administered before and / or after exercise was compared with placebo. No filters were applied by type of exercise performed, gender or age of participants. Results. In randomized controlled trials conducted for 2008-2020, evidences were obtained that the use of complexes containing curcumin normalizes the general antioxidant status, restores quality, quantity and functional-metabolic status of immunocytes.
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