Notes

Progressive as well as Degenerative Peripheral Vestibular Disorders.
Oxidative stress was increased in cases of childhood AD compared to the control group in this study. No correlation between oxidative stress and the severity of the disease was found. Larger studies are warranted.
Oxidative stress was increased in cases of childhood AD compared to the control group in this study. https://www.selleckchem.com/products/suzetrigine.html No correlation between oxidative stress and the severity of the disease was found. Larger studies are warranted.
Alopecia areata (AA) is a chronic nonscarring alopecia that involves hair follicles and is characterized by patchy areas of hair loss without any signs of clinical inflammation. Platelet-ri-ch plasma (PRP) has a high platelet concentration. Anti-inflammatory effect of PRP may be of great help in AA.

Study was conducted to compare the outcome of treatment and side effects of intralesional PRP versus triamcinolone in AA.

40 patients with alopecia areata were allocated into 2 groups and treated with triamcinolone and PRP injections. The response was analyzed by SALT score (severity of alopecia tool score) and hair regrowth grade (HRG) scale. Inferential statistical tools such as
-test, Mann-Whitney U test, and Chi-square test were used.

16 patients in each group completed the study. While comparing the decrease in SALT score at different intervals of time, there was a significant difference in SALT score reduction during the second review between PRP group and triamcinolone group (
= 0.028). After the first and final review, results did not show any statistically significant difference between the two groups. While comparing the hair regrowth scale between treatments, there was no statistical significance. 12.5% patients in PRP group reported excellent response after final review (HRG scale 4), compared to none in triamcinolone group.

Platelet-rich plasma is a safe, effective, steroid sparing, and suitable alternative in AA. Only side effect noted was pain during injections in both the groups.
Platelet-rich plasma is a safe, effective, steroid sparing, and suitable alternative in AA. Only side effect noted was pain during injections in both the groups.
Autoimmune bullous diseases (AIBD) are a heterogeneous group of diseases characterized by autoantibodies against desmosomal proteins in the pemphigus group of disorders and adhesion molecules of the dermal-epidermal junction in pemphigoid group of diseases. Direct immunofluorescence (DIF) establishes the diagnosis of AIBD by demonstrating intercellular deposits of IgG and C3 in case of pemphigus and linear deposits of IgG and C3 along the basement membrane zone (BMZ) in bullous pemphigoid (BP). BIOCHIP mosaic-based indirect immunofluorescence (IIF), a novel diagnostic approach employs detection of characteristic staining pattern and target antigens in a single miniature incubation field.

To compare the BIOCHIP mosaic-based IIF with DIF in the diagnosis of AIBD.

A total of 40 patients of AIBD in the active phase of the disease were included in the study. Skin biopsy was done in these patients for DIF study and serum was subjected to BIOCHIP mosaic-based IIF assay. The results were then compared.

DIF revealed a diagnosis of Pemphigus in 18 patients and BP in 22 patients. BIOCHIP showed a diagnosis of pemphigus in 18 patients, BP in 18 patients and floor pattern staining in four patients, which could be attributed to any of the floor pattern staining subepidermal blistering disease.

Small sample size, lack of control group and no comparison made with ELISA.

This study concludes that the result of BIOCHIP showed a significant correlation with the DIF and can be used as a first line-screening tool in the diagnosis of AIBD.
This study concludes that the result of BIOCHIP showed a significant correlation with the DIF and can be used as a first line-screening tool in the diagnosis of AIBD.
To analyze the accuracy of Tibot artificial intelligence (AI) application tool in predicting the diagnosis of dermatological conditions.

In this prospective, observational study photographs of dermatological lesions with other details of patients having different skin conditions were fed in the AI application for the diagnosis. Predictions given by the Tibot AI application were compared with diagnosis done by the dermatologist. The performance of AI application was evaluated using accuracy, precision, and recall.

Data of 398 patients were included in the application of whom 159 (39.9%) had fungal infections. Other conditions included eczema 36 (9%), alopecia 28 (7%), infestations 27 (6.8%), acne 25 (6.3%), psoriasis 19 (4.8%), benign tumors 7 (1.8%), bacterial infection 19 (4.8%), viral infection 15 (3.8%), and pigmentary disorders 20 (5%). The prediction accuracy (ability to get diagnosis in top three conditions) for alopecia, fungal infections, and eczema was 100%, 95.6%, and 91.7%, respectively. Mean prediction accuracy for correct diagnosis in the predicted top three diagnoses was 85.2%, and for correct diagnosis was 60.7%. Sensitivity and specificity of the application were approximately 86% and 98%, respectively. The sensitivity and positive predictive value of the application to diagnose alopecia was 100% and for fungal infections it was 96.85% and 90.05%, respectively.

In the preliminary stages, AI application tool showed promising results in diagnosing skin conditions. The accuracy and predictive value of the test may improve with the expansion of the database.
In the preliminary stages, AI application tool showed promising results in diagnosing skin conditions. The accuracy and predictive value of the test may improve with the expansion of the database.
Biological agents are being used as treatment of psoriasis for years. However, autoimmunity can develop after the using of these agents. Antinuclear antibody (ANA) status changes during biological therapy can be affected by certain factors including the presence of immunosuppression. We aimed to evaluate the effect of antitumor necrosis factor agents and ustekinumab on ANA status, as well as other factors leading to change in ANA status such as history of phototherapy and methotrexate combination therapy.

In this study, the laboratory findings of thirty-one patients with psoriasis who received biological agents including infliximab, etanercept, adalimumab, and ustekinumab from 2016 to 2018 managed at the department of dermatology were reviewed. The ANA status of the patients was evaluated every 2-3 months.

Twelve (38.7%) out of the thirty-one patients developed ANA positivity during treatment. Nine patients receiving infliximab, two patients receiving etanercept, and one patient receiving adalimumab developed ANA positivity.
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