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Hemodialysis (HD) and peritoneal dialysis (PD) are medically equivalent alternatives for symptomatic therapy of end-stage renal disease (ESRD). An early referral (ER) of patients with chronic kidney disease (CKD) to a nephrological specialist is associated with a higher proportion of patients choosing PD. Germany historically shows a low PD uptake. This article is the first investigation into the impact of ER on the uptake of PD, using a large German claims database.

Claims data of 4727 incident dialysis patients in 2015 and 2016 were analyzed. Accounting codes for nephrological care and dialysis modalities were identified. Their first documentation was defined as their first encounter with a nephrologist and their first dialysis treatment (HD or PD). ER was determined as receiving nephrological care at least six months before the first dialysis. A multivariate logistic regression model with adjusted odds ratios (AOR) investigates the impact of ER, outpatient dialysis start, age, comorbidities, and sex ond decisions about the dialysis treatment.Antiretroviral drugs for the treatment of human immunodeficiency virus (HIV) and other viral infections are among the emerging contaminants considered for ecological risk assessment. These compounds have been reported to be widely distributed in water bodies and other aquatic environments, while data concerning the risk they may pose to unintended non-target species in a different ecosystem (environment) is scanty. In South Africa and other developing countries, lamivudine is one of the common antiretrovirals applied. Despite this, little is known about its environmental impacts as an emerging contaminant. The present study employed a battery of ecotoxicity bioassays to assess the environmental threat lamivudine poses to aquatic fauna and flora. Daphnia magna (filter feeders), the Ames bacterial mutagenicity test, Lactuca sativa (lettuce) germination test, and the Allium cepa root tip assay were conducted, testing lamivudine at two concentrations (10 and 100 µg/L), with environmental relevance. The Daphnia mad in the environment.The cerebellum, a brain region with a high degree of plasticity, is pivotal in motor control, learning, and cognition. The cerebellar reserve is the capacity of the cerebellum to respond and adapt to various disorders via resilience and reversibility. Although structural and functional recovery has been reported in mammals and has attracted attention regarding treatments for cerebellar dysfunction, such as spinocerebellar degeneration, the regulatory mechanisms of the cerebellar reserve are largely unidentified, particularly at the circuit level. Herein, we established an optical approach using zebrafish, an ideal vertebrate model in optical techniques, neuroscience, and developmental biology. By combining two-photon laser ablation of the inferior olive (IO) and long-term non-invasive imaging of "the whole brain" at a single-cell resolution, we succeeded in visualization of the morphological changes occurring in the IO neuron population and showed at a single-cell level that structural remodeling of the olivocerebellar circuit occurred in a relatively short period. This system, in combination with various functional analyses, represents a novel and powerful approach for uncovering the mechanisms of the cerebellar reserve, and highlights the potential of the zebrafish model to elucidate the organizing principles of neuronal circuits and their homeostasis in health and disease.Spatio-temporal variations of recreation service not only could help to understand the impact of cultural services on human well-being but also provides theoretical and technical support for regional landscape management. However, previous studies have avoided deeply quantifying and analyzing it or have simply focused on assessing recreational service at a single period in time. In this study, we used the InVEST model to evaluate the spatio-temporal variations of recreation service in the Three Gorges Reservoir Area and demonstrated the impact of recreation service on landscape dynamics. The results demonstrated that recreation service increased significantly and presented a significant spatial heterogeneity. Although afforestation and urban expansion both could significantly increase recreation service, the recreation service proxy of the non-vegetation landscape is far higher than that of the vegetation landscape. This finding indicated that human landscape is more attractive to tourists than the natural landscape, so we recommend to strengthen the infrastructure construction for enhancing the accessibility of natural landscapes. Moreover, we propose other constructive suggestions and landscape-design solutions for promoting recreation service. This study shifted the static environmental health assessment to the analysis of recreation service dynamics, bridging the regulatory mechanisms of ecosystem services involved in cultural services.Non-suicidal self-injury (NSSI) is an emerging health problem among adolescents. Although previous studies have shown that deviant peer affiliation is an important risk factor for this behavior, the reasons for this relationship are unclear. Based on the integrated theoretical model of the development and maintenance of NSSI and the social development model of delinquency prevention, this study tested whether depression mediated the relationship between deviant peer affiliation and NSSI and whether this mediating effect was moderated by sensation seeking. A sample of 854 Chinese adolescents (31.50% male; Mage = 16.35; SD = 1.15) anonymously completed questionnaires on the study variables. Results of regression-based analyses showed that depression mediated the association between deviant peer affiliation and NSSI, and this effect was stronger among adolescents who reported high sensation seeking. The results demonstrate the role of individual differences in the link between affiliation with deviant peers and NSSI, and have implications for preventing and treating this risky behavior.During the COVID-19 pandemic, the market environment for the information technology (IT) industry changed dramatically, presenting companies with numerous obstacles in day-to-day management activities and changing business needs. Previous studies found that job insecurity due to COVID-19 significantly impacted millennials. Our research explored the effect of job insecurity on counterproductive work behavior among millennial employees during the COVID-19 period, using moral disengagement as a mediating variable, and psychological capital and negative emotions as moderating variables. In this study, 298 employees working in Chinese IT companies completed the questionnaire survey. We collected data from employees over three different time intervals (baseline, three weeks later, and six weeks later) to mitigate the issues of common method bias and single-source data. We analyzed the collected data using SPSS25.0 and Amos24.0 for structural modeling. Our research results indicate that job insecurity is positively associated with counterproductive work behavior, and moral disengagement plays a mediating role. In addition, psychological capital moderates the relationship between job insecurity, moral disengagement, and counterproductive work behavior. Negative emotions also moderate the mediating effect of moral disengagement between job insecurity and CWB.Background Warning apps can provide personalized public warnings, but research on their appraisal and impact on compliance is scarce. This study introduces a virtual city framework to examine affective reactions when receiving an app-based warning, and subsequent behavioral intentions. CQ31 Methods In an online experiment, 276 participants (M = 41.07, SD = 16.44, 62.0% female) were randomly allocated to one of eight groups (warning vs. no warning, thunderstorm vs. no thunderstorm, video vs. vignette). Participants were guided through a virtual city by a mock-up touristic app (t1). Then, the app issued a warning about an impending thunderstorm (t2), followed by a virtual thunderstorm (t3). The virtual city tour was presented via vignettes or videos. ANCOVAs were used to investigate trajectories of momentary anxiety, hierarchical regressions analyzed the impact of momentary anxiety on information seeking. Results Participants who received a warning message and were confronted with a thunderstorm showed the highest increase in momentary anxiety, which predicted information seeking intentions. Conclusions The findings underscore the importance of affective appraisal in processing warning messages. The virtual city framework is able to differentiate the impact of warning versus event in an online context, and thus promising for future warning research in virtual settings.Today's young people spend most of their time in contact with mobile devices. Their excessive use carries many risks, such as addiction, cyberbullying and social disruption. Based on this, this study analysed the mobile phone use of young Czechs between 7 and 17 years old (n = 27.177) and assessed the differences in their behaviour according to the mobile device use policies of their schools. The results show that the use of mobile phones was linked to the one of the social networks, YouTube and videogames for the most part. Similarly, those young people who had them at school preferred to use them, instead of practicing sports or social activities. On the other hand, in the centres in which the use of mobile phones was prohibited, they felt bored and without activities to do. Therefore, it will be necessary for schools to implement educational policies that encourage activities and areas of social interaction in the school, especially during recess. However, at the same time, it is recommended not to prohibit the use of technological devices in the educational centre, since this fact encourages students to use them secretly and increases their desire to use them. To this end, its use in the classroom is advocated from an educational perspective, thus promoting collaborative learning and increasing student motivation.Barbell placement can affect squat performance around the sticking region. This study compared kinematics, kinetics, and myoelectric activity of the safety-bar squat with the high-bar, and low-bar squat around the sticking region. Six recreationally resistance-trained men (26.3 ± 3.1 years, body mass 81 ± 7.7 kg) and eight women (22.1 ± 2.2 years, body mass 65.7 ± 10.5 kg) performed three repetition maximums in all three squat conditions. The participants lifted the least load with the safety bar followed by the high-bar and then the low-bar squat. Greater myoelectric activity of the gluteus maximus was observed during safety-bar squats than high-bar squats. Also, larger knee extension moments were observed for the safety bar compared with low-bar squat. Men had higher myoelectric activity in the safety-bar condition for the gluteus maximus during all regions in comparison with women, and greater knee valgus at the second occurrence of peak barbell velocity. Our findings suggest that the more upright torso inclination during the safety-bar could allow greater gluteus maximus contribution to the hip extensor moment. Moreover, low-bar squats allowed the greatest loads to be lifted, followed by the high-bar and safety-bar squats, possibly due to the larger hip moments and similar knee moments compared to the other squat conditions. Therefore, when the goal is to lift the greatest load possible among recreationally trained men and women, they should first attempt squatting with a low-bar technique, and if the goal is to increase myoelectric activity in the gluteus maximus, a safety-bar squat may be the more effective than the high- bar squat.
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