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Microfluidic-like production associated with steel ion-cured bioadhesives through mussels.
OBJECTIVES To measure the effects of previous Follicular Unit Transplantation (FUT) procedure. MATERIALS AND METHODS The study was conducted in a private hair transplant clinic after obtaining informed consent. Only those patients were included who had a previous strip harvest surgery (FUT) and opted for Follicular Unit Excision/Extraction (FUE) procedure. In all the patients, the donor hairs were trimmed to about 1-2 mm length. The width of the scar, the hair density above and below the scar, and hair angles above and below the scar were measured. All the patients underwent FUE procedure using 0.9 mm serrated punch. Twenty attempts were made above and below the scar (about 0.5 cm), and the total number of hair and transections was measured. All the data were analyzed statistically. RESULTS Ten patients were included. The average width of the scar was 2.47 mm. The mean hair density was found to be 155.4 hairs per cm2 above the scar and 130.8 per cm2 below the scar. The mean hair angle was found to be 28.21 degrees above the scar and 39.19 degrees below the scar in midline occipital above the scar (P less then .05). The average hair count was found to be 49.8 hairs above the scar and 47.2 hairs above the scar (P less then .05). The transection of hair was doubled below the scar (P less then .05) CONCLUSION The Follicular Unit Transplantation (FUT) procedure does leave some impacts on the donor area other than the scar only. The change in angle results in higher transection of hair above the scar. © 2020 Wiley Periodicals, Inc.BACKGROUND Hair transplant procedure is a surgical procedure which affects the sensitivity of the scalp. OBJECTIVES To compare scalp two-point discrimination (2PD) values in healthy controls and patients who had hair transplant surgery. PATIENTS/METHODS The comparative study was conducted in 25 healthy individuals and 25 patient who underwent hair transplant surgery (either strip surgery or FUE). An area was marked o scalp about 10 cm from the nasion. A caliper with 15 g weight was used. Both the prongs were ensured to be placed perpendicular to the skin. The contact time was only 2.0 seconds. An interval of 10 seconds was given before increasing the 2PD distance. In each measurement, the distance was increased by 1 mm. All the data were recorded and analyzed statistically using ANOVA test. RESULTS The mean age of the control group was 29.72 and 31.7 years in patients' group. The average 2PD score in controls was 12.76 and 17.80 mm in patients. The average 2PD score was found to be 17.7 in patients who had surgery less than 18 months ago as compared to the score of 17.6 in patients who had surgery more than 18 months ago (P > .05). The smokers had less sensitivity as compared to the nonsmokers (P less then .05). CONCLUSION The scalp sensitivity was found to be less than 39% in patients after hair transplant surgery. © 2020 Wiley Periodicals, Inc.OBJECTIVE To identify demographic and medication-related predictors of unplanned hospitalisation and combine them into a hospitalisation risk score. METHODS Patients aged ≥65 years from an outpatient multimorbidity clinic were included. Hospitalisation predictors within a year of clinic discharge were identified using logistic regression. A risk score was developed. The area under the curve (AUC) was used to assess its predictive ability, compared to that of the medicines count (definition of polypharmacy). RESULTS A total of 598 patients were included (median age of 80.0 years). 58.0% (n = 347) were hospitalised within a year of clinic discharge. The AUC for the risk score incorporating age, medicines count, heart failure (HF), atherosclerotic disease and systemic steroids was 0.67 [95% CI 0.62-0.71], compared to 0.62 [95% CI 0.58-0.67] for the medicines count. find more CONCLUSION A hospitalisation risk score incorporating demographics, medicines, namely steroids, and diseases such as HF had increased predictive ability compared to the medicines count, providing guidance for developing future polypharmacy tools. © 2020 AJA Inc.OBJECTIVES We investigated whether remote ischemic preconditioning (RIPC) inhibits agonist-induced conformational activation of platelet αIIb β3 in patients with coronary artery disease already receiving conventional antiplatelet therapy. PATIENTS/METHODS Consecutive patients with angiographically confirmed coronary artery disease were randomized to RIPC or sham treatment. Venous blood was collected before and immediately after RIPC/sham. Platelet aggregometry (ADP, arachidonic acid) and whole blood platelet flow cytometry was performed for CD62P, CD63, active αIIb β3 (PAC-1 binding) before and after stimulation with ADP, thrombin ± collagen, or PAR-1 thrombin receptor agonist. RESULTS Patients (25 RIPC, 23 sham) were well matched, 83% male, age (mean ± standard deviation) 63.3 ± 13.2 years, 95% aspirin, 81% P2Y12 inhibitor. RIPC did not affect platelet aggregation, nor agonist-induced expression of CD62P, but selectively and significantly decreased αIIb β3 activation after stimulation with either PAR-1 agonist peptide or the combination of thrombin + collagen, but not after ADP nor thrombin alone. The effect of RIPC on platelet αIIb β3 activation was evident in patients receiving both aspirin and P2Y12 inhibitor, and was not associated with an increase in vasodilator-stimulated phosphoprotein phosphorylation. CONCLUSIONS Remote ischemic preconditioning inhibits conformational activation of platelet αIIb β3 in response to exposure to thrombin and collagen in patients with coronary artery disease receiving dual antiplatelet therapy. These findings indicate agonist-specific inhibition of platelet activation by RIPC in coronary artery disease that is not obviated by the prior use of P2Y12 inhibitors. © 2020 International Society on Thrombosis and Haemostasis.AIM During pregnancy, the maternal β-cell mass is increased in order to adapt to the physiological changes in insulin demand. Lactogenic hormones stimulate rodent β-cell attachment and proliferation in vitro. The aim of this study was to identify adhesion molecules involved in expansion of the β-cell mass during pregnancy in the rat. METHODS Quantitative RT-PCR was used to evaluate the expression of several integrins and laminins in isolated neonatal rat islets in response to growth hormone (GH) and prolactin (PRL) treatment. Double-immunofluorescence staining of rat pancreas was used to localize the expression of integrin α6β1. β-cell proliferation was evaluated by incorporation of bromodeoxyuridine (BrdU). The role of STAT5 phosphorylation was tested by addition of STAT5 mutants. RESULTS We found that the mRNA level of integrin-α6A, was upregulated 2.5-fold by PRL or GH. During pregnancy, a biphasic 3.4-4.5-fold increase of integrin-α6A and B mRNA levels was detected. A disintegrin peptide (DP) reduced the hormone-stimulated mitotic activity in neonatal rat β-cells from 2.
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