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The HPLC examination of the methanol concentrate of the plant demonstrated the occurrence of different phenolic acids and flavonoids like caffeic acid (145.96μg/100mg DE), syringic acid (125.85 μg/100mg DE), ferulic acid (155.89 μg/100mg DE), apigenin (28.43 μg/100mg DE), kaempferol (53.41 μg/100mg DE) etc. in various amounts. The consequences of haemolytic lethality, cytotoxicity and genotoxicity of fluid concentrates of the edible plant ensure the security at cell and genomic level. The fluid concentrate of the plant fundamentally repressed DNA harm and these information recommend that the watery concentrate of L. cubeba can forestall oxidative DNA harm to rodent lymphocytes, which is likely because of antioxidant constituents in the concentrate. These outcomes demonstrate that L. cubeba can be utilized in dietary applications with a possibility to diminish oxidative pressure. © 2020 The Authors.This research aims to define the depth of Moho in Iran by collocation method using gravimetric data with seismic information. The definition of the Moho in the Iranian region is of considerable importance due to the geological complexity of the area also characterized by tectonic and orogenic events of particular uniqueness. We applied the collocation method to Moho recovery using the gravity data generated by GOCO03S model reduced by topography/bathymetry, sediment and consolidated crust effects from CRUST1.0. These data have been complemented with seismic Moho depth estimates. A compilation of 213-points seismic depth has been collected over Iran and used in the integrated gravimetric-seismic inversion. Among them, 140 seismic points have been selected completely random and included as data in the integrated collocation approach for Moho depth estimation. The 73 remaining seismic points have been used as checking points for validating the estimated Moho. In the first run, gravity data only have been considered to collocation Moho recovery. When comparing this gravimetric solution with the 73 seismic checking points, a standard deviation of 6.2 km was found. In case of considering the regional seismic depths into the collocation approach, the standard deviation of the residuals between our results and seismic checking Moho depths improved to 4.9 km. It must be stated that, even in the integrated inversion, a significant discrepancy between the seismic and the integrated gravimetric-seismic Moho is present in the South Caspian Basin. Low quality of CRUST1.0 could explain this inconsistency in this area. © 2020 The Author(s).Lysosomal storage diseases (LSDs) are a group of about 50 inborn errors of metabolism characterized by the lysosomal accumulation of partially or non-degraded molecules due to mutations in proteins involved in the degradation of macromolecules, transport, lysosomal biogenesis or modulators of lysosomal environment. Significant advances have been achieved in the diagnosis, management, and treatment of LSDs patients. In terms of approved therapies, these include enzyme replacement therapy (ERT), substrate reduction therapy, hematopoietic stem cell transplantation, and pharmacological chaperone therapy. In this review, we summarize the Colombian experience in LSDs thorough the evidence published. We identified 113 articles published between 1995 and 2019 that included Colombian researchers or physicians, and which were mainly focused in Mucopolysaccharidoses, Pompe disease, Gaucher disease, Fabry disease, and Tay-Sachs and Sandhoff diseases. Most of these articles focused on basic research, clinical cases, and mutation reports. Noteworthy, implementation of the enzyme assay in dried blood samples, led to a 5-fold increase in the identification of LSD patients, suggesting that these disorders still remain undiagnosed in the country. We consider that the information presented in this review will contribute to the knowledge of a broad spectrum of LSDs in Colombia and will also contribute to the development of public policies and the identification of research opportunities. © 2020 The Author(s).A raw Moroccan clay locally named "Ghassoul" (Gh) was characterized using several techniques such as Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD), Brunauer, Emmett and Teller method (BET), Scanning Electron Microscopy (SEM) and simultaneous Thermo-Gravimetric and Differential Thermal Analysis (TGA/DTA). These techniques indicate that the Gh consists essentially of steveniste, calcite, dolomite and quartz. The study of the interfacial electrochemical properties of Gh in different solutions of electrolyte salts (NaCl, CsCl, NaF, NaBr and LiCl) was carried out using the potentiometric and conductometric titrations It was shown that the Gh particles were stable in aqueous phase within the pH range (3-12) and the point of zero charge (PZC) was located at pH = 10.7. The adsorption sequence, carried out at various ionic strengths, showed that the adsorption mechanism onto the Gh particles is both electrostatic and specific at pH below the pHpzc, while at a pH range greater than the pHpzc the mechanism is electrostatic in nature. The total number of surface sites, determined using the graphical extrapolation method, was 11OH/nm2. TAS4464 price Ionization constants ( p K int + and p K int - ) in the presence of various electrolytes have also been determined and their values are 10.08 and 12.38, respectively. © 2020 Published by Elsevier Ltd.The growing interest in bioactive compounds, especially in polyphenols, is due to their abundance in the human diet and potentially positive effects on health. The consumption of polyphenols has been shown to possess anti-diabetic properties by preventing insulin resistance or insulin secretion through different signaling pathways, this effect is associated with their capacity to exert genomic modulations. Several studies have suggested that polyphenols could also bind to cellular proteins and modulate their activity, however, the mechanisms of action underlying their beneficial effects are complex and are not fully understood. The aim of this work was to characterize phenolic compounds present in blue corn and black bean extracts as well as identify their potential interactions with target proteins involved in diabetes pathogenesis using in silico approach. Total polyphenols content of both blue corn and black beans was identified using UPLC-ESI/qTOF/MS and quantified by colorimetric assays. In this work we identified twenty-eight phenolic compounds in the extracts, mainly anthocyanins, flavonols, hydroxycinamic acids, dihydroxybenzoic acids, flavones, isoflavones, and flavanols.
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