Notes

Unexplained repeated shock inside peripheral T-cell lymphoma: In a situation record.
We present Myolink, a portable, modular, low-noise electrophysiology amplifier optimized for high-density surface electromyogram (HD sEMG) acquisition.

Myolink consists of 4 modules. Each 108 cm module can concurrently acquire 32 unipolar electrode potentials at sampling rates of up to 8 kHz with 24-bit resolution. Modules may be stacked and operated synchronously, supporting the concurrent acquisition of up to 128 channels. A custom high-performance analog front-end provides an input-referred-noise < 0.4 VRMS for a bandwidth of 23-524 Hz (tuneable by design choices), which is lower than current commercial systems. Digitized signals are processed by a custom on-board FPGA-based controller and subsequently transmitted to a PC via a medical-grade isolated USB2.0 interface.

The system has been tested by recording experimental HD sEMG signals, which have been subsequently decomposed into motor unit action potentials. Compared to commercially available systems, the proposed recording system led to higher-quality surface EMG acquisition, as well as higher decomposition accuracy across a wide range of forces, with the greater gain for forces 20% of the maximum voluntary contraction.

A portable, ultra-low-noise, HD sEMG amplifier design has been implemented and characterized. The system provides IRN performance beyond the capabilities of current state-of-the-art instrumentation and this improvement has a significant effect on HD sEMG decomposition.
A portable, ultra-low-noise, HD sEMG amplifier design has been implemented and characterized. The system provides IRN performance beyond the capabilities of current state-of-the-art instrumentation and this improvement has a significant effect on HD sEMG decomposition.Adult stem cells are maintained in niches, specialized microenvironments that regulate their self-renewal and differentiation. In the adult Drosophila testis stem cell niche, somatic hub cells produce signals that regulate adjacent germline stem cells (GSCs) and somatic cyst stem cells (CySCs). Hub cells are normally quiescent, but after complete genetic ablation of CySCs, they can proliferate and transdifferentiate into new CySCs. Here we find that Epidermal growth factor receptor (EGFR) signaling is upregulated in hub cells after CySC ablation and that the ability of testes to recover from ablation is inhibited by reduced EGFR signaling. In addition, activation of the EGFR pathway in hub cells is sufficient to induce their proliferation and transdifferentiation into CySCs. We propose that EGFR signaling, which is normally required in adult cyst cells, is actively inhibited in adult hub cells to maintain their fate but is repurposed to drive stem cell regeneration after CySC ablation.George Lewis Elliot has not been given his proper due as the first dean of dentistry in Canada. Elliot was in the center of a scandal, surrounding his establishment of a private dental school, the Canada College of Dentistry. Faced with a regulatory body whose leaders he perceived to be engaging in the practice "choking off" and "stamping out" their competitors, Elliot undertook to create an independent dental school to provide prospective licentiates with the means to pass the board exams, thereby also improving the profession.Accounts of dental history in Queensland are few and almost invariably authored by those who either held or hold power. The focus is 'who, what, when' rather than 'why and how'. House-related developments as a case study provide an opportunity to assess aspects of the Australian Dental Association Queensland Branch's (ADAQ) model of administration in the early 1970s. The authors use literature review and historical methods. The ADAQ's articles of association, codes of conduct and memoranda centralized Brisbane-based authority and elite leadership into its management. The ADAQ council's decision to build Christensen House in Brisbane, prompted by the posthumous benevolence of George Christensen, was informed, logical, measured and appeared timely. The advocates for the house were innovative, optimistic, resolute, and well-intentioned, with their design and selected location of the building being appropriate. However, the decision occurred at a time of latent discontent within the membership, many of whom did not support the project financially. Distance in Queensland dictates that provincial members either accept or tolerate Brisbane-based centralized authority within ADAQ administration. Nonetheless, when it comes to policy warranting membership subscription, the Christensen House experience demonstrates that the modus operandi of the ADAQ council should be, as far as possible, inclusive, and representative.Musée de la Cour d'Or, Metz, France, possesses a female skull bearing a gold wire dental appliance claimed in a 1934 Dental Cosmos article on the history of dental prosthetics to be 'probably' Merovingian in origin. Inquiries in 2017 revealed current museum curators were unaware of this claim but were skeptical of such dating suggesting scientific analysis might provide clarity. Carbon dating of a tooth from the skull was carried out placing the artifact in the mid seventeenth-late eighteenth centuries while Metz historical records reveal the find site was occupied by a convent of nuns for most of C14 dated period. Strontium isotopic analysis indicates the woman was a local of the Metz region while fluorine analysis indicates exposure to fluoride early in life. Oral health status and the dentistry indicate the woman was of high social status.Teaching history of dentistry and/or medicine in dental schools is not a priority today. A half a century ago it was part of a significant number of dental school curricula. As advances in science occurred and more demand on the curriculum were made, history of medicine and dentistry (HMD) was largely cast aside. In a recent survey of 393 dental programs in 100 countries on five continents, only 18.8% have a stand-alone course in HMD. MAT2A inhibitor Nearly half of the programs though have at least 1-2 hours of curriculum time devoted to HMD. When we consider a subset of the above survey, only 5% of dental schools in the US and Canada have a stand-alone course. The exclusion of HMD from current dental curricula is shortsighted. Teaching only current and state-of-the art aspects of dentistry is like showing a still image from the end of a movie without watching the rest.In the process of reading from a wide variety of both historical and contemporary sources, which is what an editor must do, I have found it painfully obvious when reading dental articles that claim to provide historical reviews, along with details of such that rarely are the original sources either identified or investigated thoroughly to provide accuracy in content. I will use the following example that is commonly seen and that focuses within my specialty, Endodontics.Recently, along with increasing use of immune checkpoint inhibitors such as nivolumab, the incidence of immune-related adverse events, including type 1 diabetes mellitus, has become a serious problem. We report a patient who had immune checkpoint inhibitor‒associated type 1 diabetes mellitus that developed after a second mRNA-based SARS-CoV-2 vaccination.Cervical cancer is one of the most common malignancies among females. As a virus-related cancer, cervical cancer has attracted a lot of attention to develop virus-targeted immune therapy, including vaccine and adoptive immune cell therapy (ACT). Adoptive tumor infiltrating lymphocytes (TILs) cell therapy has been found to be able to control advanced disease progression in some cervical cancer patients who have received several lines of treatment in a pilot clinical trial. In addition, sustainable therapeutic effect has been identified in some cases. The safety risks of TIL therapy for patients are minimal or at least manageable. In this review, we focused on the versatility of TILs and tried to summarize potential strategies to improve the therapeutic effect of TILs and discuss related perspectives.Insomnia is a common late effect of cancer, affecting as many as 27% of cancer survivors. Although cognitive behavioral therapy for insomnia (CBT-I) is highly effective, treatment-associated burdens and limited availability of providers result in few survivors receiving this treatment. To address this gap, we developed the Sleep Treatment Education Program-1 (STEP-1), a single-session intervention addressing insomnia after cancer. As a preliminary evaluation of STEP-1's potential to improve survivors' insomnia, STEP-1 was delivered to a convenience sample of 34 cancer survivors as an educational workshop in person or by videoconference. Participants completed the Insomnia Severity Index (ISI) at the workshop and at 1-month follow-up; items assessing participants' intentions to implement program suggestions and satisfaction were also collected. At 1-month follow-up, mean insomnia symptoms on the ISI were significantly lower compared to baseline (9.73 vs 15.73; d = 1.38, P  less then  .001); the reduction in mean ISI scores did not significantly differ between in-person and videoconference participants (5.82 vs 6.33; P = .78). These results, along with positive indicators of program engagement and satisfaction, support the potential efficacy of STEP-1 to meet survivors' needs for insomnia care. Particularly when delivered by videoconference, STEP-1 has the potential to dramatically improve access and uptake for insomnia treatment in cancer survivors. Results also more generally support development of low-intensity, self-management insomnia interventions for cancer survivors and potentially other populations.This study examines the mediating role of social support between anxious preoccupation and resilience in patients with cancer during COVID-19. NEOetic_SEOM is a prospective, multicenter study involving individuals with advanced, unresectable cancer who completed the following scales Resilience (BCRS), Social Support (Duke-UNC-11), and anxious preoccupation subscale of the Mini-Mental Adjustment to Cancer (M-MAC) before starting antineoplastic treatment. Between March 2020 and July 2021, 507 patients (55% male; mean age, 65) were recruited. No differences in resilience were observed based on sociodemographic or clinical characteristics. Social support in people with advanced, unresectable cancer promotes both decreased anxious preoccupation and greater resilience.Koolen-de Vries syndrome (KdVS) is a genomic disorder characterized by intellectual disability, heart failure, hypotonia and congenital malformations, which is caused by haploinsufficiency of KANSL1. Because the pathogenesis of the disease is unknown, there is still no effective treatment. Here, we discuss our recent work identifying KANSL1 as an essential gene for macroautophagy/autophagy. We find that KANSL1 modulates autophagosome-lysosome fusion for cargo degradation by transcriptionally regulating Stx17 expression. Kansl1 heterozygous mice exhibit impaired neuronal and cardiac functions, resulting from the obstruction of autophagic clearance of damaged mitochondria and accumulation of reactive oxygen species in these tissues. Furthermore, we discovered an FDA-approved drug, 13-cis retinoic acid, is capable of alleviating these mitophagic defects and neurobehavioral abnormalities in Kansl1 heterozygous mice by promoting autophagosome-lysosome fusion via directly binding to STX17 and SNAP29. Our study provides the proof of concept to set up a link between KANSL1, autophagic defects and KdVS, and also proposes a therapeutic strategy for treatment of KdVS.
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