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Neurotoxin-related optic neuritis (ON) after snake bite is uncommon. Here, we present a case of a 70-year-old female who developed bilateral painless loss of vision after she received treatment with anti-snake venom (ASV). She had only perception of light on assessment of visual acuity on admission which then improved drastically after administration of intravenous methylprednisolone (MP) after making the provisional diagnosis of ON on the basis of history and clinical findings of the patient. Imaging and visual-evoked potential could not be done initially, and they were done after the administration of intravenous MP which had normal findings. ASV, though being a lifesaving treatment, has been sometimes associated with ON.Isaac syndrome (IS) is a peripheral nerve hyperexcitability state associated with voltage-gated potassium channel (VGKC) complex antibodies. Major manifestations are muscle twitching, stiffness, hypertrophy, and dysautonomic features such as hyperhidrosis [Ahmed and Simmons. Muscle Nerve. 2015;52(1)5-12]. Neuropathic pain is a rare manifestation. We describe a case of IS characterized by muscle twitching and intractable neuropathic pain. Diagnostic workup included elevated VGKC complex antibodies and EMG/NC that showed neuromyotonic discharges. Neuropathic pain was initially difficult to relieve even after using multiple medications, including opiates, benzodiazepines, anticonvulsants, and intravenous immunoglobulin (IVIg). Moderate pain control was eventually achieved with long-term use of carbamazepine and subcutaneous immunoglobulin (SCIg). Common manifestations of IS are muscle twitching, stiffness hypertrophy, and dysautonomia [Ahmed and Simmons. Muscle Nerve. 2015;52(1)5-12]. Sensory manifestations such as neuropathic pain are rare, but, as illustrated by our patient, can be the most distressing symptom. In our patient, not only was neuropathic pain disabling but it also showed the least response to IVIg. The use of 200 mg of long-acting carbamazepine twice daily with weekly SCIg demonstrated the best response. This case highlights an uncommon but potentially resistant symptom of IS.Bariatric surgery is used as a treatment for morbid obesity and often results in rapid weight loss. This procedure has been associated with postoperative nutritional deficiencies. Neurological complications due to nutritional deficiencies include Wernicke encephalopathy, a disorder that affects the central and peripheral nervous system due to thiamine (vitamin B1) deficiency. Wernicke encephalopathy can lead to irreversible consequences if not treated early. Here, we present a case of a 40-year-old woman that developed Wernicke encephalopathy 2 months after gastric bypass surgery, with additional findings of flat affect and concurrent polyradiculopathy. Her diagnosis was delayed due to unique symptoms and an initial workup with negative imaging findings, making the identification of this disorder more complex.Ocular disorders constitute a major component of the non-motor symptoms of Parkinson's disease (PD). Blurry vision is commonly associated with PD, but often challenging to interpret. AGK2 The clinical spectrum of blurred vision is broad, and finding the underlying aetiology can be challenging. An incomplete diagnosis impedes therapeutic successes. We report two persons with PD who both experienced blurry vision, but each with a different underlying pathology that called for specific ophthalmological and neurological treatments. In case 1, the blurry vision was presumably caused by strabismus and convergence insufficiency, while case 2 had blurry vision partly due to palinopsia, a higher order visual processing deficit. Adequate treatment improved vision in both cases. Neurologists should be aware of the different underlying causes of blurred vision, should master the basic therapeutic approaches, and know when to refer a patient to the ophthalmology department.In this study, a multi-objective optimization of directed energy deposition (DED) process was conducted with Taguchi-Grey relational analysis. The used part was designed as a flat rectangle which would be deposited by a single-layer and multi-track DED process. Firstly, after finishing Taguchi experiments, the effects of five control factors (laser power, overlap ratio, powder feed rate, scanning speed and laser defocus distance) on three DED product qualities (cladding efficiency, surface roughness and porosity) were, respectively, analyzed. Then, through Grey relational analysis (GRA), an optimal factor setting which can take all qualities into account was found and had better deposition results compared with previous setting. Furthermore, ANOVAs were conducted to find out significant factors of each qualities. By using the significant factors as variations, three second-order polynomial regression predictive models for qualities were created. Based on the GRA and ANOVAs results, additional one-factor-at-a-time (OFAT) experiments which used the optimal setting as the center point were performed. The qualities variation resulting from adjusting overlap ratio and laser defocus distance of optimal setting were investigated, and the results were also used as additional data to verified the accuracies of three regression models.We addressed the frequent occurrence of mixed-chain lipids in biological membranes and their impact on membrane structure by studying several chain-asymmetric phosphatidylcholines and the highly asymmetric milk sphingomyelin. Specifically, we report trans-membrane structures of the corresponding fluid lamellar phases using small-angle X-ray and neutron scattering, which were jointly analyzed in terms of a membrane composition-specific model, including a headgroup hydration shell. Focusing on terminal methyl groups at the bilayer center, we found a linear relation between hydrocarbon chain length mismatch and the methyl-overlap for phosphatidylcholines, and a non-negligible impact of the glycerol backbone-tilting, letting the sn1-chain penetrate deeper into the opposing leaflet by half a CH2 group. That is, penetration-depth differences due to the ester-linked hydrocarbons at the glycerol backbone, previously reported for gel phase structures, also extend to the more relevant physiological fluid phase, but are significantly reduced. Moreover, milk sphingomyelin was found to follow the same linear relationship suggesting a similar tilt of the sphingosine backbone. Complementarily performed molecular dynamics simulations revealed that there is always a part of the lipid tails bending back, even if there is a high interdigitation with the opposing chains. The extent of this back-bending was similar to that in chain symmetric bilayers. For both cases of adaptation to chain length mismatch, chain-asymmetry has a large impact on hydrocarbon chain ordering, inducing disorder in the longer of the two hydrocarbons.
Cardiovascular disorders have been extensively reported during COVID-19 illness, including arrhythmias such as atrioventricular conduction disturbances. To date, one case of transient heart block has been reported after COVID-19 vaccine.

A 73 years-old woman presented with shortness of breath and fatigue 2 weeks after receiving her second dose of BNT162b2 SARS-CoV-2 mRNA vaccine. ECG showed complete AV block with normal narrow QRS complexes. Chronic treatment with Bisoprolol for hypertension was stopped but complete AV block persisted 48 hours thereafter. Therefore, a permanent pacemaker was implanted. Three months later, pacemaker follow-up revealed no ventricular stimulation, suggesting complete recovery of AV conduction, even after resumption of bisoprolol. Five months after the second dose, she received a third dose of the same vaccine. Three weeks later, she once again complained of dyspnea on exertion. ECG showed sinus rhythm with permanent ventricular stimulation. After device inhibition, complete AV block was confirmed and, 2 weeks later, conduction was restored once more.

It is known that vaccines can induce AV conduction disturbances, mostly reversible. The underlying mechanisms leading to high-degree AV block remain unclear and are probably multiple. Although being exceptional after COVID-19 vaccine, our case illustrates the fact that the latter can induce such a disturbance which may be transient and recurrent even in the absence of underlying conduction disorder.

COVID-19 vaccination may transitorily interfere with cardiac conduction system even in subjects without known underlying heart disease.
COVID-19 vaccination may transitorily interfere with cardiac conduction system even in subjects without known underlying heart disease.In this study, nanocomplexes composed of glycyrrhizic acid (GA) derived from the root of the licorice plant (Glycyrrhiza glabra) were formulated for the delivery of curcumin (CUR). Sonication of amphiphilic GA solution with hydrophobic CUR resulted in the production of nanosized complexes with a size of 164.8 ± 51.7 nm, which greatly enhanced the solubility of CUR in aqueous solution. A majority of the CURs were released from these GA/ CUR nanocomplexes within 12 h. GA/CUR nanocomplexes exhibited excellent intracellular uptake in human breast cancer cells (Michigan cancer foundation-7/multi-drug resistant cells), indicating enhanced anti-cancer effects compared to that of free CUR. In addition, GA/CUR nanocomplexes demonstrated high intracellular uptake into macrophages (RAW264.7 cells), consequently reducing the release of the pro-inflammatory cytokine tumor necrosis factor-α. Furthermore, GA/CUR nanocomplexes successfully reduced the levels of serum pro-inflammatory cytokines and splenomegaly in a rheumatoid arthritis model.With Coronavirus disease 2019 (COVID-19) continuous spread there is a great need for understanding factors leading to vaccination in order to effectively encourage people to take the vaccine. The current dataset consists of a number of variables potentially explaining vaccination intention, that is perceived disease severity, trait-reactance, demographics and variables associated with The Theory of Planned Behavior (attitudes toward vaccination, importance of social and moral norms when considering vaccination, perceived behavioral control). The sample consists of 551 self-reports, based on the demographic (gender and age) structure of 18-70+ year-olds in Poland. This data might be used for further exploration of the relationships between trait reactance and COVID-19 vaccination intention, as well as for cross-cultural comparisons. In the original paper, the authors have conducted a series of factor analyses, regressions, correlations and developed a structural model.
Oral potentially malignant disorders (OPMDs) represent a heterogeneous set of different histological lesions, characterized by the capacity to transform in oral squamous cell carcinoma (OSCC). Despite optimal surgical treatment, approximately 20%-30% of OPMDs may evolve into OSCC. No clear clinical/histological factors are able to identify OPMDs at higher risk of malignant transformation.

We considered surgically treated patients with a diagnosis of OPMDs, enrolled from 1996 to 2019 at ASST Spedali Civili of Brescia without a diagnosis of OSCC within the previous 2 years. Clinical and histological characteristics were recorded. Outcomes of interest were recurrence-free survival (RFS), defined as the time from surgery for primary OPMD to any relapse of OPMD or malignant transformation, whichever occurred first, and carcinoma-free survival (CFS), defined as the time from surgery for OPMD to malignant transformation.

We retrospectively reviewed 106 OPMDs cases. Median age at first diagnosis was 64 years old (IQR = 18.
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