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PHYTOCHROME-INTERACTING FACTORs trigger eco sensitive chromatin characteristics in vegetation.
In order to improve the response speed and output force of the camera focusing mechanism, the authors proposed a novelty micro focusing mechanism based on piezoelectric driving, which has the characteristics of rapid response, high precision positioning and large displacement focusing. In this paper, the operating principle of the proposed focusing mechanism is presented. Using the piezoelectric output characteristic, the movable tooth drive theory and the screw drive theory, the electromechanical coupling mechanical model and equations of the piezoelectric focusing mechanism are established. Through MATLAB simulation, the output characteristics of the piezoelectric focusing mechanism are calculated. The results indicate that the maximum thrust force of the lens and the maximum output torque of the movable tooth drive for the piezoelectric focusing mechanism are 562.5 N and 1.16 Nm, respectively. selleck chemicals llc Furthermore, the driving voltage directly affects the output performance of the piezoelectric focusing mechanism. These results can be utilized both to optimize the dimensions and improve the overall performance of the piezo-driven focusing mechanism.To quantify the variation of red blood cells (RBCs) or plasma proteins in blood samples effectively, it is necessary to measure blood viscosity and erythrocyte sedimentation rate (ESR) simultaneously. Conventional microfluidic measurement methods require two syringe pumps to control flow rates of both fluids. In this study, instead of two syringe pumps, two air-compressed syringes (ACSs) are newly adopted for delivering blood samples and reference fluid into a T-shaped microfluidic channel. Under fluid delivery with two ACS, the flow rate of each fluid is not specified over time. To obtain velocity fields of reference fluid consistently, RBCs suspended in 40% glycerin solution (hematocrit = 7%) as the reference fluid is newly selected for avoiding RBCs sedimentation in ACS. A calibration curve is obtained by evaluating the relationship between averaged velocity obtained with micro-particle image velocimetry (μPIV) and flow rate of a syringe pump with respect to blood samples and reference fluid. By installing the ACSs horizontally, ESR is obtained by monitoring the image intensity of the blood sample. The averaged velocities of the blood sample and reference fluid () over time. As a demonstration, the proposed method is employed to quantify contributions of hematocrit (Hct = 30%, 40%, and 50%), base solution (1× phosphate-buffered saline [PBS], plasma, and dextran solution), and hardened RBCs to blood viscosity and ESR, respectively. Experimental Results of the present method were comparable with those of the previous method. In conclusion, the proposed method has the ability to measure blood viscosity and ESR consistently, under fluid delivery of two ACSs.The relationship between academic performance and alcohol consumption among students remains inconsistent. We assessed this relationship, controlling for sociodemographic characteristics across seven faculties at the University of Turku (1177 undergraduates). An online questionnaire assessed seven sociodemographic characteristics (age, gender, year/discipline of study, accommodation type, being in intimate relationship, parental education, and income sufficiency); two perceived academic performance (students' subjective importance of achieving good grades and students' appraisal of their academic performance compared to peers); and six alcohol consumption behaviors (length of time, amount consumed, frequency, heavy episodic drinking, problem drinking, and possible alcohol dependence). Simple logistic regression assessed relationships between sociodemographic and academic variables with alcohol consumption behaviors; multiple logistic regression assessed the same relationships after controlling for all other variables. Students reported long duration and large amount of drinking (46% and 50%), high frequency of drinking (41%), heavy episodic drinking (66%), problem drinking (29%), and possible alcohol dependence (9%). After controlling, gender was associated with all alcohol consumption behaviors, followed by religiosity (associated with four alcohol behaviors), living situation, marital status, age (each associated with two alcohol behaviors), and parental education and year of study (each associated with one alcohol behavior). Study discipline, income sufficiency, importance of achieving good grades, and academic performance compared to peers were not associated with any alcohol behaviors. Universities need to assess problem drinking and alcohol use disorders among students. Prevention strategies are required to reduce risk. Health promotion efforts could focus on beliefs and expectations about alcohol and target student groups at risk for more efficient and successful efforts.Language barriers play a critical role in the treatment of migrant and refugeepatients. In Germany, primary care interpreters are often not available especially in rural areas or ifpatients demand spontaneous or urgent consultations. Methods In order to enable patients and theirphysicians to communicate effectively about the current illness history, we developed a digitalcommunication assistance tool (DCAT) for 19 different languages and dialects. This paper reportsthe multidisciplinary process of the conceptual design and the iterative development of this crossculturaluser-centered application in an action-oriented approach. Results We piloted our app with36 refugee patients prior to a clinical study and used the results for further development. Theacceptance and usability of the app by patients was high. Conclusion Using digital tools forovercoming language barriers can be a feasible approach when providing health care to foreignlanguagepatients.Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) modulates various cell functions through IGF-dependent or independent mechanisms. However, its biological roles in the radiosensitivity of oral squamous cell carcinoma (OSCC) remain largely unknown. The purpose of this study was to determine the clinical significance and molecular mechanisms of the association between IGFBP-3 and OSCC radiosensitivity. We performed an immunohistochemical analysis of IGFBP-3 in 52 OSCC specimens from patients treated with preoperative chemoradiotherapy and surgery (phase II study). Associations between IGFBP-3 expression and clinicopathological features were also evaluated. In addition, we examined the effects of IGFBP-3 on post-X-ray irradiation radiosensitivity and DNA damage in vitro. High IGFBP-3 expression was significantly correlated with poor chemoradiotherapy responses and prognosis. With IGFBP-3 knockdown, irradiated OSCC cells exhibited significantly higher radiosensitivity compared with that of control cells.
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