Notes

Growth and development of specialized medical pharmacy packages incorporated into affected individual care walkways making use of adverse event pitfalls.
05). The incidence of perinephric hematoma (≥4 cm
) in elderly patients with renal biopsy was lower than that in non-elderly patients. We noted that 79.9% of primary glomerulonephritis patients who received immunosuppressive therapy showed a remission rate of 83.5%.

The spectrum of kidney disease in the elderly is different from that in the younger population.
The spectrum of kidney disease in the elderly is different from that in the younger population.
Pooling of individual-level data for workers involved in uranium refining and processing (excluding enrichment) may provide valuable insights into risks from occupational uranium and external ionizing radiation exposures.

Data were pooled for workers from four uranium processing facilities (Fernald, Mallinckrodt and Middlesex from the U.S.; and Port Hope, Canada). Employment began as early as the 1930s and follow-up was as late as 2017. Workers were exposed to high concentrations of uranium, radium, and their decay products, as well as gamma radiation and ambient radon decay products. Exposure and outcome data were harmonized using similar definitions and dose reconstruction methods. Standardized mortality ratios (SMR) were estimated.

In total, 560 deaths from lung cancer, 503 non-malignant respiratory diseases, 67 renal diseases, 1,596 ischemic heart diseases, and 101 dementia and Alzheimer's disease (AD) were detected in the pooled cohort of over 12,400 workers (∼1,300 females). Mean cumulative doses were 45 millisievert for whole-body external ionizing radiation exposure and 172 milligray for lung dose from radon decay products. Only SMR for dementia and AD among males was statistically significant (SMR=1.29; 95% confidence interval 1.04, 1.54).

This is the largest study to date to examine long-term health risks of uranium processing workers.
This is the largest study to date to examine long-term health risks of uranium processing workers.
Transcriptomic-based approaches are being developed to meet the needs for large-scale radiation dose and injury assessment and provide population triage following a radiological or nuclear event. This review provides background and definition of the need for new biodosimetry approaches, and summarizes the major advances in this field. It discusses some of the major model systems used in gene signature development, and highlights some of the remaining challenges, including individual variation in gene expression, potential confounding factors, and accounting for the complexity of realistic exposure scenarios.

Transcriptomic approaches show great promise for both dose reconstruction and for prediction of individual radiological injury. However, further work will be needed to ensure that gene expression signatures will be robust and appropriate for their intended use in radiological or nuclear emergencies.
Transcriptomic approaches show great promise for both dose reconstruction and for prediction of individual radiological injury. However, further work will be needed to ensure that gene expression signatures will be robust and appropriate for their intended use in radiological or nuclear emergencies.
Although radiotherapy is a common treatment option for all kinds of cancer patients, including ovarian cancer, a major obstacle limiting its application in the development of resistance. Therefore, it is urgently needed to clarify the mechanism of radiosensitivity modulation.

We obtained open datasets and analyzed the expression of collagen type XI alpha 1 (COL11A1) in ovarian cancer patients with different stages. Meanwhile, the correlation of COL11A1 and survival outcomes is determined by Kaplan-Meier analysis. The role of COL11A1 in cell proliferation was observed in an invitro knockdown system. SKOV3 radioresistant cells were established to determine the role of COL11A1 on radioresistant in ovarian cancer.

COL11A1 were highly enriched in late-stage ovarian cancer tumor tissues and negatively correlated with survival outcomes in ovarian cancer. The functional analysis found that COL11A1 promoted ovarian cancer cell proliferation invitro. Importantly, COL11A1 decreased radiosensitivity in ovarian cancer by AKT activation. Paired related homeobox 1 (PRRX1) acted as an upstream transcription factor to regulate COL11A1 expression in ovarian cancer. Increased COL11A1 expression is related to low survival outcomes and radiosensitivity in ovarian cancer.

Targeting COL11A1 is a promising strategy for improving radiotherapy efficiency.
Targeting COL11A1 is a promising strategy for improving radiotherapy efficiency.
Long-term potentiation (LTP) is an important functional indicator for synaptic plasticity. Extremely low frequency electromagnetic fields (ELF-EMFs) are a physical means to regulate LTP, which induce induced currents. It is unknown whether induced current is the key factor when LTP is regulated by ELF-EMFs.New Method A method is proposed for calculating the current value induced by ELF-EMFs. mTOR inhibitor Then, a comparison of ELF-EMFs with current on the regulation of theta-burst or high-frequency stimulation (TBS/HFS)-LTP was performed.

The LTP after ELF-EMFs and μA current regulation was significantly reduced. The regulatory effect of 0.1 μA current on LTP was similar with 100 Hz/2 mT ELF-EMFs, while 0.2 μA had a stronger regulatory effect than 200 Hz/2 mT on HFS-LTP.Comparison with Existing Methods Most of the existing methods were used to calculate the induced current in human models, while we present a more accurate model for calculating the induced current induced by ELF-EMFs in the rat brain slices.

This work indicated that μA current and ELF-EMFs stimulation reduced LTP. Also, we demonstrated that the regulatory effect of ELF-EMFs on LTP is not entirely deriving from the induced current, since its magnetic mechanism might have played a certain role.
This work indicated that μA current and ELF-EMFs stimulation reduced LTP. Also, we demonstrated that the regulatory effect of ELF-EMFs on LTP is not entirely deriving from the induced current, since its magnetic mechanism might have played a certain role.Pediatric neuroblastoma (NB) patients receive multi-modal therapy and may experience care fragmented among multiple institutions with a significant travel burden, which has been associated with poor outcomes for some adult cancers. We hypothesized that fragmented care for pediatric NB patients is associated with inferior outcomes compared to treatment consolidated at one location. We reviewed paper and electronic records for pediatric NB patients who received ≥1 hematopoietic stem cell transplant (HSCT) at Duke from 1990-2017. Fragmented care was defined by treatment at >1 institution and grouped by 2 institutions vs. 3+ institutions. Distances were calculated using Google Maps. To compare all care groups, we used Fisher's Exact and Kruskal-Wallis tests for demographic and treatment characteristics, Kaplan-Meier for unadjusted overall survival (OS), and Cox proportional hazards for factors associated with OS. Of 127 eligible patients, 102 (80.3%) patients experienced fragmented care, with 17 treated at 3+ facilities.
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